Efnb1 ephrin B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efnb1provided by MGI
Official Full Name: ephrin B1provided by MGI
Primary source: MGI:MGI:102708
See related: Ensembl:ENSMUSG00000031217 AllianceGenome:MGI:102708
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epl2; EFL-3; Elk-L; Eplg2; Lerk2; Stra1; Cek5-L; LERK-2
Summary: This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in lung adult (RPKM 47.3), colon adult (RPKM 44.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (98179667..98192628)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (99136061..99149022)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests.
Title: Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Title: RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Craniomaxillofacial morphology in a murine model of ephrinB1 conditional deletion in osteoprogenitor cells.
Title: Craniomaxillofacial morphology in a murine model of ephrinB1 conditional deletion in osteoprogenitor cells.
Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
Title: Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
Conditional knockout of ephrinB1 in osteogenic progenitors delays the process of endochondral ossification during fracture repair.
Title: Conditional knockout of ephrinB1 in osteogenic progenitors delays the process of endochondral ossification during fracture repair.
Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development.
Title: Expression and localisation of ephrin-B1, EphB2, and EphB4 in the mouse testis during postnatal development.
Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.
Title: Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.
Using mice harboring mutations in the Efnb1 and in Ephb1-3 receptor genes in different embryonic tissues study established the tissue-specific contributions of EPHRIN-B1 mosaicism to craniofacial dysmorphology and revealed specific cellular context and signaling interactions that are likely to underlie craniofrontonasal syndrome providing new understanding of how EPHRIN-B1 may regulate normal craniofacial development.
Title: Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.
EphrinB1, expressed by osteoprogenitors, influences bone loss during the development of osteoporosis, by regulating both osteoblast and osteoclast formation and function, leading to a loss of skeletal integrity.
Title: The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption.
Our findings demonstrate that astrocytic ephrin-B1 regulates long-term contextual memory by restricting new synapse formation in the adult hippocampus
Title: Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (14) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Efnb1 (e-PCR), detects polymorphism
- UniSTS:495876

AA964352 (e-PCR)
- UniSTS:248424

EFNB1_609 (e-PCR)
- UniSTS:277189

Efnb1 (e-PCR), detects polymorphism
- UniSTS:266982

Efnb1 (e-PCR), detects polymorphism
- UniSTS:506876

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin-B1

Names: CEK5 receptor ligand; Cek ligand; ELK ligand; EPH-related receptor tyrosine kinase ligand 2; stimulated by retinoic acid gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.