Efna5 ephrin A5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efna5provided by MGI
Official Full Name: ephrin A5provided by MGI
Primary source: MGI:MGI:107444
See related: Ensembl:ENSMUSG00000048915 AllianceGenome:MGI:107444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AL-1; Epl7; RAGS; EFL-5; LERK-7; Ephrin-A5
Summary: Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 6.9) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1; 17 32.57 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (62909949..63188431, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (62602957..62881317, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5(-/-) mice.
Title: Concurrent LI-rTMS induces changes in c-Fos expression but not behavior during a progressive ratio task with adult ephrin-A2A5(-/-) mice.
Ephrin-A5 Is Involved in Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.
Title: Ephrin-A5 Is Involved in Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy.
Reduced expression of ephrin-A5 accelerates disease progression in an animal model of amyotrophic lateral sclerosis.
Title: Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.
The loss of Ephrin-A2 and A5 ligands did not impact on the rate of wound closure or re-innervation after injury. However, changes in the gross morphology of the healed scar and in collagen histology of the scar dermis were observed in transgenic mice. Therefore Ephrin-A2 and A5 ligands may play an important role in final scar appearance associated with collagen deposition and structure.
Title: Ephrin-A2 affects wound healing and scarring in a murine model of excisional injury.
The results demonstrated that Efna5 is a pro-apoptotic agent in granulosa cells and plays important role in folliculogenesis by mediating apoptosis, proliferation, and steroidogenesis in female mouse.
Title: Regulatory roles of ephrinA5 and its novel signaling pathway in mouse primary granulosa cell apoptosis and proliferation.
Study showed that in comparison with wild-type mice revealed that ephrin-A2A5-/- mice had reduced accuracy and response rates, suggesting a goal-directed behavioral deficit, which was improved by low intensity repetitive transcranial magnetic stimulation.
Title: Online LI-rTMS during a Visual Learning Task: Differential Impacts on Visual Circuit and Behavioral Plasticity in Adult Ephrin-A2A5(-/-) Mice.
that Epha2 and Efna5 participate in the complex, global patterning of lens fiber cells that is necessary for maximal optical quality
Title: Epha2 and Efna5 participate in lens cell pattern-formation.
This study demonstrated for a role of ephrinA signaling for the selective targeting of serotonergic raphe nuclei. We show that EphA5 is differentially expressed across the different hindbrain raphe nuclei, and that this correlates with a different repulsive action of ephrinA on 5-HT axon growth.
Title: EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.
these results suggest that the basic helix-loop-helix transcription factorsbinding site in ECR1 is involved in the positive regulation of ephrin-A5 gene expression during the development of the mesencephalon.
Title: Identification of an Enhancer Critical for the ephirn-A5 Gene Expression in the Posterior Region of the Mesencephalon.
During urogenital development, different modes of Eph/Ephrin signaling occur at several sites with EphrinB2 and EphrinA5 acting in concert.
Title: Multimodal Eph/Ephrin signaling controls several phases of urogenital development.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Mit183 (e-PCR), detects polymorphism
- UniSTS:128002

Efna5 (e-PCR), detects polymorphism
- UniSTS:495875

AV158822 (e-PCR)
- UniSTS:164627

EFNA5 (e-PCR)
- UniSTS:504935

NoName (e-PCR)
- UniSTS:237676

UniSTS:237678 (e-PCR)
- UniSTS:237678

NoName (e-PCR)
- UniSTS:548476

BE116204 (e-PCR)
- UniSTS:248452

NoName (e-PCR)
- UniSTS:485023

WI-15986 (e-PCR)
- UniSTS:34784

Efna5 (e-PCR), detects polymorphism
- UniSTS:266981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables neurotrophin TRKB receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to forskolin	IDA Inferred from Direct Assay more info	PubMed
involved_in collateral sprouting	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ephrin-A5

Names: EPH-related receptor tyrosine kinase ligand 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413234.1 → NP_001400163.1 ephrin-A5 isoform 3

Status: VALIDATED

Source sequence(s)

AC134243, AC154385
NM_010109.4 → NP_034239.1 ephrin-A5 isoform 2 precursor

See identical proteins and their annotated locations for NP_034239.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC134243, AC154385

Consensus CDS

CCDS28934.1

UniProtKB/Swiss-Prot

O08543

Related

ENSMUSP00000077883.5, ENSMUST00000078839.5

Conserved Domains (1) summary

cd10425
Location:30 → 159

Ephrin-A_Ectodomain; Ectodomain of Ephrin A
NM_207654.3 → NP_997537.1 ephrin-A5 isoform 1 precursor

See identical proteins and their annotated locations for NP_997537.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC134243, AC154385

Consensus CDS

CCDS28935.1

UniProtKB/Swiss-Prot

O08543, O08544

Related

ENSMUSP00000076115.6, ENSMUST00000076840.12

Conserved Domains (1) summary

cd10425
Location:30 → 159

Ephrin-A_Ectodomain; Ectodomain of Ephrin A