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Eef2k eukaryotic elongation factor-2 kinase [ Mus musculus (house mouse) ]

Gene ID: 13631, updated on 3-Apr-2024

Summary

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Official Symbol
Eef2kprovided by MGI
Official Full Name
eukaryotic elongation factor-2 kinaseprovided by MGI
Primary source
MGI:MGI:1195261
See related
Ensembl:ENSMUSG00000035064 AllianceGenome:MGI:1195261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
eEF-2K
Summary
Enables calmodulin binding activity and elongation factor-2 kinase activity. Involved in regulation of protein autophosphorylation. Predicted to be located in dendritic spine and postsynaptic density. Is expressed in liver; lung; nervous system; and olfactory epithelium. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 19.4), colon adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 64.95 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120442080..120506441)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120842642..120907219)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 42E, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6592 Neighboring gene STARR-positive B cell enhancer ABC_E1360 Neighboring gene STARR-positive B cell enhancer ABC_E10469 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon TAG) Neighboring gene predicted gene, 36449 Neighboring gene predicted gene 15774 Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells. Das JK, et al. Sci Adv, 2022 Feb 4. PMID 35108044, Free PMC Article
  2. Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36. Fernando S, et al. FASEB J, 2022 Feb. PMID 35032419
  3. Eef2k is not required for fertility in male mice. Feng T, et al. Transl Androl Urol, 2021 May. PMID 34159079, Free PMC Article
  4. D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis. David O, et al. Front Mol Neurosci, 2020. PMID 32499677, Free PMC Article
  5. Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine. Adaikkan C, et al. Biol Psychiatry, 2018 Jul 1. PMID 29395043

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
    Title: Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS-STING pathway in hepatocellular carcinoma.
  2. Control of CD4[+] T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
    Title: Control of CD4(+) T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.
  3. Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24[Bst] Mouse.
    Title: Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24(Bst) Mouse.
  4. eEF2K promotes PD-L1 stabilization through inactivating GSK3beta in melanoma.
    Title: eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
  5. miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
    Title: miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K.
  6. [Effects of GSK3beta/eEF2K signaling pathway on pulmonary fibrosis in mice].
    Title: [Effects of GSK3β/eEF2K signaling pathway on pulmonary fibrosis in mice].
  7. Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
    Title: Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K).
  8. Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
    Title: Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells.
  9. Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
    Title: Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36.
  10. Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
    Title: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables elongation factor-2 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables elongation factor-2 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables elongation factor-2 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation factor activity, RNA binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in myosin II filament disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation at postsynapse ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic elongation factor 2 kinase
Names
calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
eEF-2 kinase
eukaroytic elongation factor 2 kinase
NP_001254639.1
NP_001254640.1
NP_001399257.1
NP_001399258.1
NP_001399259.1
NP_001399260.1
NP_001399261.1
NP_001399262.1
NP_001399263.1
NP_031934.1
XP_036008548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267710.2 → NP_001254639.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_001254639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000102098.2, ENSMUST00000106489.9
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

  2. NM_001267711.2 → NP_001254640.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_001254640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000102097.2, ENSMUST00000106488.3
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

  3. NM_001412328.1 → NP_001399257.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  4. NM_001412329.1 → NP_001399258.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  5. NM_001412330.1 → NP_001399259.1  eukaryotic elongation factor 2 kinase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248
    UniProtKB/Swiss-Prot
    O08796

  6. NM_001412331.1 → NP_001399260.1  eukaryotic elongation factor 2 kinase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  7. NM_001412332.1 → NP_001399261.1  eukaryotic elongation factor 2 kinase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  8. NM_001412333.1 → NP_001399262.1  eukaryotic elongation factor 2 kinase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

  9. NM_001412334.1 → NP_001399263.1  eukaryotic elongation factor 2 kinase isoform d

    Status: VALIDATED

    Source sequence(s)
    AC122248

  10. NM_007908.5 → NP_031934.1  eukaryotic elongation factor 2 kinase isoform a

    See identical proteins and their annotated locations for NP_031934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC122214, AC122248
    Consensus CDS
    CCDS21796.1
    UniProtKB/Swiss-Prot
    O08796
    UniProtKB/TrEMBL
    Q7TPC7, Q8BNP6, Q8CEC8
    Related
    ENSMUSP00000046595.9, ENSMUST00000047875.16
    Conserved Domains (3) summary
    COG0790
    Location:492 → 688
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:502 → 535
    SLR; SLR repeat [structural motif]
    cd16967
    Location:102 → 317
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase

RNA

  1. NR_178189.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122214, AC122248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120442080..120506441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152655.1 → XP_036008548.1  eukaryotic elongation factor 2 kinase isoform X4

    UniProtKB/TrEMBL
    Q8BNP6
    Conserved Domains (3) summary
    COG0790
    Location:351 → 547
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:361 → 394
    SLR; SLR repeat [structural motif]
    cd16967
    Location:1 → 176
    Alpha_kinase_eEF2K; Alpha-kinase domain of eukaryotic elongation factor-2 kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08796.1 GenPept UniProtKB/Swiss-Prot:O08796

Gene LinkOut

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