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SVOPL SVOP like [ Homo sapiens (human) ]

Gene ID: 136306, updated on 3-Apr-2024

Summary

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Official Symbol
SVOPLprovided by HGNC
Official Full Name
SVOP likeprovided by HGNC
Primary source
HGNC:HGNC:27034
See related
Ensembl:ENSG00000157703 MIM:611700; AllianceGenome:HGNC:27034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC22B5
Summary
The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See SVOPL in Genome Data Viewer
Location:
7q34
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (138594285..138701362, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (139903966..140013811, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138279030..138386107, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 24 Neighboring gene RPS3A pseudogene 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26743 Neighboring gene uncharacterized LOC124901755 Neighboring gene Sharpr-MPRA regulatory region 10989 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ribosomal protein L21 pseudogene 73 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:138352744-138353325 Neighboring gene ribosomal protein L17 pseudogene 27 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 2 Neighboring gene ATPase H+ transporting V0 subunit a4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:138429227-138429398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138434906-138435708 Neighboring gene MPRA-validated peak6777 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138458197-138458700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138458701-138459203 Neighboring gene Sharpr-MPRA regulatory region 1249 Neighboring gene transmembrane protein 213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy. Hu L, et al. Oncogene, 2017 Feb 23. PMID 27593939
  2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative transporter SVOPL
Names
SV2 related protein homolog-like
solute carrier family 22 member B5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051552.1 RefSeqGene

    Range
    5186..112263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1103

mRNA and Protein(s)

  1. NM_001139456.2 → NP_001132928.1  putative transporter SVOPL isoform 1

    See identical proteins and their annotated locations for NP_001132928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC013429, AC020983
    Consensus CDS
    CCDS47721.1
    UniProtKB/Swiss-Prot
    Q8N434
    Related
    ENSP00000501457.1, ENST00000674285.1
    Conserved Domains (2) summary
    cd06174
    Location:51 → 480
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00895
    Location:34 → 454
    2A0115; benzoate transport

  2. NM_001331192.1 → NP_001318121.1  putative transporter SVOPL isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC013429, AC020983
    Conserved Domains (1) summary
    cl26863
    Location:2 → 397
    Sugar_tr; Sugar (and other) transporter

  3. NM_174959.3 → NP_777619.1  putative transporter SVOPL isoform 2

    See identical proteins and their annotated locations for NP_777619.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL704123, BC036796, BX349158
    Consensus CDS
    CCDS5848.1
    UniProtKB/TrEMBL
    C9JVJ9
    Related
    ENSP00000417018.1, ENST00000436657.5
    Conserved Domains (1) summary
    cl26863
    Location:6 → 336
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    138594285..138701362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515797.3 → XP_011514099.1  putative transporter SVOPL isoform X3

    See identical proteins and their annotated locations for XP_011514099.1

    UniProtKB/TrEMBL
    C9JVJ9
    Conserved Domains (1) summary
    cl26863
    Location:6 → 336
    Sugar_tr; Sugar (and other) transporter

  2. XM_024446655.2 → XP_024302423.1  putative transporter SVOPL isoform X1

    Conserved Domains (1) summary
    cl26863
    Location:2 → 397
    Sugar_tr; Sugar (and other) transporter

  3. XM_017011748.2 → XP_016867237.1  putative transporter SVOPL isoform X3

    UniProtKB/TrEMBL
    C9JVJ9
    Conserved Domains (1) summary
    cl26863
    Location:6 → 336
    Sugar_tr; Sugar (and other) transporter

  4. XM_047419888.1 → XP_047275844.1  putative transporter SVOPL isoform X4

  5. XM_017011747.2 → XP_016867236.1  putative transporter SVOPL isoform X3

    UniProtKB/TrEMBL
    C9JVJ9
    Conserved Domains (1) summary
    cl26863
    Location:6 → 336
    Sugar_tr; Sugar (and other) transporter

  6. XM_047419887.1 → XP_047275843.1  putative transporter SVOPL isoform X2

  7. XM_024446654.2 → XP_024302422.1  putative transporter SVOPL isoform X1

    Conserved Domains (1) summary
    cl26863
    Location:2 → 397
    Sugar_tr; Sugar (and other) transporter

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    139903966..140013811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357251.1 → XP_054213226.1  putative transporter SVOPL isoform X3

  2. XM_054357248.1 → XP_054213223.1  putative transporter SVOPL isoform X1

  3. XM_054357252.1 → XP_054213227.1  putative transporter SVOPL isoform X3

  4. XM_054357253.1 → XP_054213228.1  putative transporter SVOPL isoform X4

  5. XM_054357250.1 → XP_054213225.1  putative transporter SVOPL isoform X3

  6. XM_054357247.1 → XP_054213222.1  putative transporter SVOPL isoform X1

  7. XM_054357249.1 → XP_054213224.1  putative transporter SVOPL isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N434.2 GenPept UniProtKB/Swiss-Prot:Q8N434

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