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PRSS37 serine protease 37 [ Homo sapiens (human) ]

Gene ID: 136242, updated on 5-Mar-2024

Summary

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Official Symbol
PRSS37provided by HGNC
Official Full Name
serine protease 37provided by HGNC
Primary source
HGNC:HGNC:29211
See related
Ensembl:ENSG00000165076 AllianceGenome:HGNC:29211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRYX2
Summary
Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of acrosome reaction and regulation of protein processing. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 1.6) See more
Orthologs
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Genomic context

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Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (141836278..141841485, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (143152100..143157307, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141536078..141541285, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MT-ND1 pseudogene 3 Neighboring gene MYL6 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:141537551-141537755 Neighboring gene olfactory receptor family 9 subfamily A member 3 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr7:141575140-141575702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:141576176-141576676 Neighboring gene olfactory receptor family 9 subfamily A member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. Liu J, et al. Acta Biochim Biophys Sin (Shanghai), 2016 Nov. PMID 27649891
  2. Isoform-specific GSK3A activity is negatively correlated with human sperm motility. Freitas MJ, et al. Mol Hum Reprod, 2019 Apr 1. PMID 30824926, Free PMC Article
  3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in germ cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
probable inactive serine protease 37
Names
Peptidase S1 domain-containing protein LOC136242
probable inactive trypsin-X2
protease, serine 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008270.3 → NP_001008271.2  probable inactive serine protease 37 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008271.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA628371, AC093638, AK172866, BC137353
    Consensus CDS
    CCDS34764.1
    UniProtKB/Swiss-Prot
    A4D1T9, B2RPB5
    Related
    ENSP00000297767.3, ENST00000350549.8
    Conserved Domains (1) summary
    cl21584
    Location:28 → 231
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001171951.2 → NP_001165422.1  probable inactive serine protease 37 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001165422.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA628371, AC093638, AK172866, BC144605
    UniProtKB/TrEMBL
    B7ZMK3
    Conserved Domains (2) summary
    smart00020
    Location:28 → 227
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:28 → 230
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001370403.1 → NP_001357332.1  probable inactive serine protease 37 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093638
    Consensus CDS
    CCDS34764.1
    UniProtKB/Swiss-Prot
    A4D1T9, B2RPB5
    Related
    ENSP00000414461.1, ENST00000438520.1
    Conserved Domains (1) summary
    cl21584
    Location:28 → 231
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    141836278..141841485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249947.4 → XP_005250004.1  probable inactive serine protease 37 isoform X1

    See identical proteins and their annotated locations for XP_005250004.1

    Conserved Domains (2) summary
    smart00020
    Location:28 → 258
    Tryp_SPc; Trypsin-like serine protease
    cl21584
    Location:28 → 261
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_047419883.1 → XP_047275839.1  probable inactive serine protease 37 isoform X2

  3. XM_047419884.1 → XP_047275840.1  probable inactive serine protease 37 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    143152100..143157307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357235.1 → XP_054213210.1  probable inactive serine protease 37 isoform X1

  2. XM_054357236.1 → XP_054213211.1  probable inactive serine protease 37 isoform X2

  3. XM_054357237.1 → XP_054213212.1  probable inactive serine protease 37 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4D1T9.1 GenPept UniProtKB/Swiss-Prot:A4D1T9

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