Sparcl1 SPARC-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sparcl1provided by MGI
Official Full Name: SPARC-like 1provided by MGI
Primary source: MGI:MGI:108110
See related: Ensembl:ENSMUSG00000029309 AllianceGenome:MGI:108110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sc1; Ecm2; hevin; mast9
Summary: Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in synaptic membrane adhesion. Located in glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; male reproductive gland or organ; respiratory system; and sensory organ. Orthologous to human SPARCL1 (SPARC like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 525.6), cortex adult (RPKM 355.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.55 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104226974..104261954, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (104079108..104114088, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder.
Title: The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder.
Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
Title: Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
Downregulation of Sparc-like protein 1 during cisplatin-induced inhibition of myogenic differentiation of C2C12 myoblasts.
Title: Downregulation of Sparc-like protein 1 during cisplatin-induced inhibition of myogenic differentiation of C2C12 myoblasts.
Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability.
Title: Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability.
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.
Title: Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.
Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2.
Title: Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2.
Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair.
Title: Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair.
Spinal hevin mediates membrane trafficking of GluA1-containing AMPA receptors in remifentanil-induced postoperative hyperalgesia in mice.
Title: Spinal hevin mediates membrane trafficking of GluA1-containing AMPA receptors in remifentanil-induced postoperative hyperalgesia in mice.
SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Title: SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.
Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis.
Title: Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SPARCL1 (e-PCR)
- UniSTS:279130

Sparcl1 (e-PCR), detects polymorphism
- UniSTS:142957

Sparcl1 (e-PCR), detects polymorphism
- UniSTS:142958

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix of synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SPARC-like protein 1

Names: SPARC-like 1 (mast9, hevin); extracellular matrix protein 2; matrix glycoprotein Sc1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359014.1 → NP_001345943.1 SPARC-like protein 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AL714024

Consensus CDS

CCDS19483.1

UniProtKB/Swiss-Prot

E9QPH2, P70663, P97810, Q99L82

UniProtKB/TrEMBL

Q3TYD5, Q3UYK7

Conserved Domains (3) summary

COG5271
Location:60 → 317

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16231
Location:501 → 641

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins

cl00097
Location:419 → 498

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
NM_001359016.1 → NP_001345945.1 SPARC-like protein 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AL714024

Consensus CDS

CCDS19483.1

UniProtKB/Swiss-Prot

E9QPH2, P70663, P97810, Q99L82

UniProtKB/TrEMBL

Q3TYD5, Q3UYK7

Conserved Domains (3) summary

COG5271
Location:60 → 317

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16231
Location:501 → 641

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins

cl00097
Location:419 → 498

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
NM_010097.4 → NP_034227.3 SPARC-like protein 1 precursor

See identical proteins and their annotated locations for NP_034227.3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK134608, AK158725, BY277497, CD742522

Consensus CDS

CCDS19483.1

UniProtKB/Swiss-Prot

E9QPH2, P70663, P97810, Q99L82

UniProtKB/TrEMBL

Q3TYD5, Q3UYK7

Related

ENSMUSP00000031249.4, ENSMUST00000031249.8

Conserved Domains (3) summary

COG5271
Location:60 → 317

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16231
Location:501 → 641

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins

cl00097
Location:419 → 498

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

104226974..104261954 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164777.1 → XP_036020670.1 SPARC-like protein 1 isoform X1

UniProtKB/Swiss-Prot

E9QPH2, P70663, P97810, Q99L82

UniProtKB/TrEMBL

Q3TYD5, Q3UYK7

Conserved Domains (3) summary

COG5271
Location:60 → 317

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16231
Location:501 → 641

EFh_SPARC_like; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC) and similar proteins

cl00097
Location:419 → 498

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...