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Dyrk1b dual-specificity tyrosine phosphorylation regulated kinase 1b [ Mus musculus (house mouse) ]

Gene ID: 13549, updated on 21-Apr-2024

Summary

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Official Symbol
Dyrk1bprovided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 1bprovided by MGI
Primary source
MGI:MGI:1330302
See related
Ensembl:ENSMUSG00000002409 AllianceGenome:MGI:1330302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mirk
Summary
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within myoblast fusion. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 39.4), thymus adult (RPKM 16.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 16.67 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27878880..27896896)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28179447..28197910)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6526 Neighboring gene predicted gene, 31024 Neighboring gene fibrillarin Neighboring gene STARR-positive B cell enhancer ABC_E9687 Neighboring gene STARR-seq mESC enhancer starr_18404 Neighboring gene STARR-seq mESC enhancer starr_18406 Neighboring gene STARR-seq mESC enhancer starr_18407 Neighboring gene STARR-seq mESC enhancer starr_18408 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene leucine twenty homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288. Zou Y, et al. J Biol Chem, 2004 Jun 25. PMID 15075324
  2. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics. Zhuang L, et al. Circulation, 2022 Mar 15. PMID 35235343
  3. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Bhat N, et al. J Clin Invest, 2022 Feb 1. PMID 34855620, Free PMC Article
  4. DYRK1B regulates Hedgehog-induced microtubule acetylation. Singh R, et al. Cell Mol Life Sci, 2019 Jan. PMID 30317528
  5. Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Masuda T, et al. Proc Natl Acad Sci U S A, 2012 Jul 3. PMID 22711815, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
    Title: Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
  2. DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
    Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
  3. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
    Title: Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
  4. we demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1
    Title: Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1-induced cell cycle arrest.
  5. Through the activation of DYRK1B, Hedgehog signaling facilitates microtubule-dependent processes such as intracellular mitochondrial transport, mesenchymal cell polarization or directed cell migration.
    Title: DYRK1B regulates Hedgehog-induced microtubule acetylation.
  6. results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
    Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.
  7. Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
    Title: Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice.
  8. BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk
    Title: G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.
  9. Mirk may function together with GSK3beta to assist cell arrest by destabilizing cyclin D1.
    Title: Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
  10. p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase
    Title: The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in adipose tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B
Names
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
NP_001033046.1
NP_001258299.1
NP_034222.1
XP_006539589.1
XP_006539590.1
XP_030097944.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037957.4 → NP_001033046.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

    See identical proteins and their annotated locations for NP_001033046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform p69, also known as isoform b.
    Source sequence(s)
    AC141883
    Consensus CDS
    CCDS21037.1
    UniProtKB/Swiss-Prot
    Q3UFR5, Q70UR5, Q9EPM2, Q9Z188
    Related
    ENSMUSP00000083064.7, ENSMUST00000085901.13
    Conserved Domains (2) summary
    smart00220
    Location:111 → 431
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:97 → 436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. NM_001271370.2 → NP_001258299.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p75

    See identical proteins and their annotated locations for NP_001258299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (p75), also known as isoform c, that has a longer N-terminus, compared to isoform p69.
    Source sequence(s)
    AC141883
    Consensus CDS
    CCDS85251.1
    UniProtKB/Swiss-Prot
    Q9Z188
    Related
    ENSMUSP00000133431.3, ENSMUST00000172467.8
    Conserved Domains (2) summary
    smart00220
    Location:171 → 491
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:157 → 496
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  3. NM_010092.3 → NP_034222.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

    See identical proteins and their annotated locations for NP_034222.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform p65, also known as isoform a, which is shorter than isoform p69.
    Source sequence(s)
    AC141883
    Consensus CDS
    CCDS57532.1
    UniProtKB/Swiss-Prot
    Q9Z188
    Related
    ENSMUSP00000133719.2, ENSMUST00000172761.8
    Conserved Domains (2) summary
    smart00220
    Location:111 → 391
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:97 → 396
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27878880..27896896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242084.2 → XP_030097944.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

    Conserved Domains (1) summary
    cd14226
    Location:97 → 408
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. XM_006539526.4 → XP_006539589.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    Conserved Domains (2) summary
    PHA03378
    Location:3 → 147
    PHA03378; EBNA-3B; Provisional
    cd14226
    Location:157 → 468
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  3. XM_006539527.5 → XP_006539590.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

    Conserved Domains (2) summary
    PHA03378
    Location:3 → 147
    PHA03378; EBNA-3B; Provisional
    cd14226
    Location:157 → 456
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RNA

  1. XR_003946384.2 RNA Sequence

  2. XR_003946385.2 RNA Sequence

  3. XR_003946383.2 RNA Sequence

  4. XR_004934006.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z188.3 GenPept UniProtKB/Swiss-Prot:Q9Z188

Gene LinkOut

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