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Dyrk1a dual-specificity tyrosine phosphorylation regulated kinase 1a [ Mus musculus (house mouse) ]

Gene ID: 13548, updated on 11-Apr-2024

Summary

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Official Symbol
Dyrk1aprovided by MGI
Official Full Name
dual-specificity tyrosine phosphorylation regulated kinase 1aprovided by MGI
Primary source
MGI:MGI:1330299
See related
Ensembl:ENSMUSG00000022897 AllianceGenome:MGI:1330299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik
Summary
Enables several functions, including identical protein binding activity; protein self-association; and tau protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 55.3 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94370770..94496378)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94569947..94695519)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene predicted gene, 23692 Neighboring gene predicted gene, 31323 Neighboring gene STARR-positive B cell enhancer ABC_E1498 Neighboring gene STARR-positive B cell enhancer ABC_E9431 Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene STARR-seq mESC enhancer starr_41576 Neighboring gene STARR-seq mESC enhancer starr_41578 Neighboring gene STARR-positive B cell enhancer ABC_E5566 Neighboring gene STARR-positive B cell enhancer mm9_chr16:94853523-94853824 Neighboring gene predicted gene, 53922 Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41505 Neighboring gene predicted gene, 41507

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis. Dard R, et al. Genes (Basel), 2021 Nov 16. PMID 34828406, Free PMC Article
  2. Skeletal Deficits in Male and Female down Syndrome Model Mice Arise Independent of Normalized Dyrk1a Expression in Osteoblasts. Thomas JR, et al. Genes (Basel), 2021 Oct 28. PMID 34828335, Free PMC Article
  3. Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Fructuoso M, et al. Mol Neurobiol, 2020 Jul. PMID 32504418
  4. Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome. Chang P, et al. Cell Rep, 2020 Jan 28. PMID 31995755, Free PMC Article
  5. Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice. Velazquez R, et al. Mol Neurobiol, 2019 Dec. PMID 31240602

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes.
    Title: MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes.
  2. miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation.
    Title: miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation.
  3. Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
    Title: Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
  4. Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.
    Title: Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.
  5. Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.
    Title: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.
  6. Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status.
    Title: Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status.
  7. Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.
    Title: Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.
  8. An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
    Title: An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
  9. Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling.
    Title: Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling.
  10. Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.
    Title: Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.
Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC150253, MGC150254

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3T45 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables tau protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with neurofilament ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1A
Names
dual specificity YAK1-related kinase
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
protein kinase minibrain homolog
NP_001106860.1
NP_001334660.1
NP_001389720.1
NP_001389721.1
NP_001389722.1
NP_031916.1
XP_011244397.1
XP_036015668.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113389.1 → NP_001106860.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    See identical proteins and their annotated locations for NP_001106860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK052390, AK163136, BC129888, CB526389, CX566606
    Consensus CDS
    CCDS28350.1
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A9C475
    Related
    ENSMUSP00000023614.5, ENSMUST00000023614.5
    Conserved Domains (1) summary
    cd14226
    Location:148 → 484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. NM_001347731.2 → NP_001334660.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/TrEMBL
    A1L341
    Conserved Domains (1) summary
    cd14226
    Location:139 → 475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  3. NM_001402791.1 → NP_001389720.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A9C475

  4. NM_001402792.1 → NP_001389721.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190

  5. NM_001402793.1 → NP_001389722.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165271, CT030190
    UniProtKB/TrEMBL
    F6U6X3
    Related
    ENSMUSP00000112853.3, ENSMUST00000122284.9

  6. NM_007890.2 → NP_031916.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

    See identical proteins and their annotated locations for NP_031916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK052390, AK163136, BC129888, BF462682, CD540384, CX566606
    Consensus CDS
    CCDS28350.1
    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A9C475
    Related
    ENSMUSP00000113660.2, ENSMUST00000119878.8
    Conserved Domains (1) summary
    cd14226
    Location:148 → 484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    94370770..94496378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159775.1 → XP_036015668.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

    UniProtKB/TrEMBL
    A1L341
    Conserved Domains (1) summary
    cd14226
    Location:139 → 475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. XM_011246095.4 → XP_011244397.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

    See identical proteins and their annotated locations for XP_011244397.1

    UniProtKB/Swiss-Prot
    Q61214
    UniProtKB/TrEMBL
    A9C475
    Conserved Domains (1) summary
    cd14226
    Location:148 → 484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61214.1 GenPept UniProtKB/Swiss-Prot:Q61214

Gene LinkOut

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