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Adam28 a disintegrin and metallopeptidase domain 28 [ Mus musculus (house mouse) ]

Gene ID: 13522, updated on 11-Apr-2024

Summary

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Official Symbol
Adam28provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 28provided by MGI
Primary source
MGI:MGI:105988
See related
Ensembl:ENSMUSG00000014725 AllianceGenome:MGI:105988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDCL; Dtgn1; MDC-L; eMDCII; TECADAM; C130072N01Rik; D430033C21Rik
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are typically membrane-anchored, although a form of this protein may be secreted. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein may bind to integrins and regulate lymphocyte migration by enhancing cell adhesion. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward genital fat pad adult (RPKM 58.0) See more
Orthologs
human all
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Genomic context

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Location:
14 D1; 14 35.69 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68842447..68893338, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68604998..68655889, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37047 Neighboring gene predicted gene, 41191 Neighboring gene ADAM-like, decysin 1 Neighboring gene STARR-seq mESC enhancer starr_37048 Neighboring gene translation machinery-associated protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37049 Neighboring gene STARR-seq mESC enhancer starr_37050 Neighboring gene predicted gene, 46476 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69369284-69369585 Neighboring gene predicted gene, 31281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma. Bendavid G, et al. Front Immunol, 2022. PMID 36685493, Free PMC Article
  2. Modulation of integrin α4β1 by ADAM28 promotes lymphocyte adhesion and transendothelial migration. McGinn OJ, et al. Cell Biol Int, 2011 Oct. PMID 21332445
  3. Microenvironment-derived ADAM28 prevents cancer dissemination. Gérard C, et al. Oncotarget, 2018 Dec 14. PMID 30647853, Free PMC Article
  4. An ADAM family member with expression in thymic epithelial cells and related tissues. Haidl ID, et al. Gene, 2002 Jan 23. PMID 11867223
  5. Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28. Howard L, et al. Biochem J, 2000 May 15. PMID 10794709, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
    Title: Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.
  2. The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage.
    Title: CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.
  3. The authors report that recombinant human MDC-L (ADAM 28) protein with the disintegrin domain binds to the alpha(4)beta(1) integrin, and this binding may regulate the interaction between lymphocytes and leukocytes expressing alpha(4)beta(1).
    Title: The lymphocyte metalloprotease MDC-L (ADAM 28) is a ligand for the integrin alpha4beta1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 28
Names
ADAM 28
a disintegrin and metalloprotease domain 28
a disintegrin and metalloproteinase domain 28
disintegrin 1
metalloproteinase-disintegrin domain containing protein TECADAM
thymic epithelial cell-ADAM
NP_001041640.1
NP_034212.1
NP_899222.1
XP_006518577.1
XP_017171325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048175.2 → NP_001041640.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001041640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1. It is not known whether this isoform (4) is proteolytically processed in the same manner as isoform 1.
    Source sequence(s)
    AK078982, AK136715, BB629805, CT025563
    Consensus CDS
    CCDS36964.1
    UniProtKB/TrEMBL
    Q71U12
    Related
    ENSMUSP00000106701.2, ENSMUST00000111072.8
    Conserved Domains (5) summary
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:419 → 491
    Disintegrin; Disintegrin
    pfam01421
    Location:206 → 402
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:42 → 156
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_010082.2 → NP_034212.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK136715, BB629805, CT025563
    Consensus CDS
    CCDS36965.1
    UniProtKB/Swiss-Prot
    Q5D070, Q8K5D2, Q8K5D3, Q9JLN6
    UniProtKB/TrEMBL
    Q71U12
    Related
    ENSMUSP00000022642.6, ENSMUST00000022642.6
    Conserved Domains (5) summary
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:419 → 491
    Disintegrin; Disintegrin
    pfam01421
    Location:206 → 402
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:42 → 156
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_183366.3 → NP_899222.1  disintegrin and metalloproteinase domain-containing protein 28 isoform 2 precursor

    See identical proteins and their annotated locations for NP_899222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1. It is not known whether this isoform (2) is proteolytically processed in the same manner as isoform 1.
    Source sequence(s)
    AK136715, BB629805, CT025563
    Consensus CDS
    CCDS88698.1
    UniProtKB/TrEMBL
    Q71U12
    Related
    ENSMUSP00000153354.2, ENSMUST00000224039.2
    Conserved Domains (5) summary
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:419 → 491
    Disintegrin; Disintegrin
    pfam01421
    Location:206 → 402
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:42 → 156
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. NR_102399.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK078982, AK136715, BB629805, CT025563

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    68842447..68893338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518514.4 → XP_006518577.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

    UniProtKB/TrEMBL
    Q71U12
    Conserved Domains (4) summary
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:419 → 491
    Disintegrin
    pfam01562
    Location:31 → 158
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_017315836.2 → XP_017171325.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

    UniProtKB/TrEMBL
    Q71U12
    Conserved Domains (4) summary
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:419 → 491
    Disintegrin
    pfam01562
    Location:31 → 158
    Pep_M12B_propep; Reprolysin family propeptide

RNA

  1. XR_001781095.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176991.1: Suppressed sequence

    Description
    NM_176991.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLN6.3 GenPept UniProtKB/Swiss-Prot:Q9JLN6

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