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Epyc epiphycan [ Mus musculus (house mouse) ]

Gene ID: 13516, updated on 21-Apr-2024

Summary

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Official Symbol
Epycprovided by MGI
Official Full Name
epiphycanprovided by MGI
Primary source
MGI:MGI:107942
See related
Ensembl:ENSMUSG00000019936 AllianceGenome:MGI:107942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dspg3; PG-Lb; SLRR3B
Summary
Acts upstream of or within articular cartilage development; bone development; and sensory perception of sound. Located in extracellular matrix. Is expressed in foot; nervous system; notochord; sensory organ; and skeleton. Orthologous to human EPYC (epiphycan). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 25.0), testis adult (RPKM 5.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
10 C3; 10 50.35 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97479930..97517770)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97644068..97681908)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40749 Neighboring gene keratocan Neighboring gene predicted gene 10754 Neighboring gene RIKEN cDNA 4930525C09 gene Neighboring gene STARR-seq mESC enhancer starr_27692 Neighboring gene coiled-coil glutamate-rich protein 1 Neighboring gene predicted gene, 25658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The gene structure and organization of mouse PG-Lb, a small chondroitin/dermatan sulphate proteoglycan. Iwata Y, et al. Biochem J, 1998 May 1. PMID 9560328, Free PMC Article
  2. Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing. Hanada Y, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28864419
  3. Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA. Kurita K, et al. Biochem J, 1996 Sep 15. PMID 8836137, Free PMC Article
  4. Expression and localization of PG-Lb/epiphycan during mouse development. Johnson J, et al. Dev Dyn, 1999 Dec. PMID 10633869
  5. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Danielson KG, et al. Mamm Genome, 1999 Feb. PMID 9922406

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epyc is necessary for normal auditory function
    Title: Epiphycan is specifically expressed in cochlear supporting cells and is necessary for normal hearing.
  2. Epyc is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in articular cartilage development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within articular cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
epiphycan
Names
dermatan sulfate proteoglycan 3
dermatan sulphate proteoglycan 3
proteoglycan-Lb
small chondroitin/dermatan sulfate proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379456.1 → NP_001366385.1  epiphycan precursor

    Status: VALIDATED

    Source sequence(s)
    AC099715, AC159710
    UniProtKB/Swiss-Prot
    P70186
    UniProtKB/TrEMBL
    Q3TZF5
    Related
    ENSMUSP00000100922.4, ENSMUST00000105285.4
    Conserved Domains (3) summary
    PRK15370
    Location:126 → 317
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:145 → 168
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:151 → 203
    LRR_8; Leucine rich repeat

  2. NM_007884.2 → NP_031910.1  epiphycan precursor

    See identical proteins and their annotated locations for NP_031910.1

    Status: VALIDATED

    Source sequence(s)
    AK015223
    Consensus CDS
    CCDS24143.1
    UniProtKB/Swiss-Prot
    P70186
    UniProtKB/TrEMBL
    Q3TZF5
    Related
    ENSMUSP00000020094.2, ENSMUST00000020094.8
    Conserved Domains (3) summary
    PRK15370
    Location:126 → 317
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:145 → 168
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:151 → 203
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    97479930..97517770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70186.1 GenPept UniProtKB/Swiss-Prot:P70186

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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