Dscam DS cell adhesion molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dscamprovided by MGI
Official Full Name: DS cell adhesion moleculeprovided by MGI
Primary source: MGI:MGI:1196281
See related: Ensembl:ENSMUSG00000050272 AllianceGenome:MGI:1196281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4932410A21Rik
Summary: Enables netrin receptor binding activity and protein tyrosine kinase binding activity. Involved in generation of neurons; negative regulation of cell adhesion; and netrin-activated signaling pathway. Acts upstream of or within dendrite morphogenesis; locomotory behavior; and post-embryonic retina morphogenesis in camera-type eye. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Is expressed in several structures, including central nervous system; peripheral nervous system; sensory organ; skin; and testis. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 4.0), CNS E18 (RPKM 3.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 57.02 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (96388652..96971935, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (96587452..97171113, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.
Title: Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.
DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.
Title: DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models.
Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.
Title: Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice.
DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
Title: DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.
DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions.
Title: DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions.
DSCAM2J mutation alters the repertoire of gaits according to the mouse's age and speed, and prevents fast gaits.
Title: Age- and speed-dependent modulation of gaits in DSCAM(2J) mutant mice.
The diversity resides on the adhesive side, positioning DSCAM as a generalized modulator of cell adhesion during neural development.
Title: DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members.
Results identify DSCAM-cell-adhesion molecule-mediated inhibition as a regulator of circuit-level neuronal plasticity in the adult mice retina.
Title: DSCAM-mediated control of dendritic and axonal arbor outgrowth enforces tiling and inhibits synaptic plasticity.
Findings indicate Down syndrome cell adhesion molecule (Dscam) as a permissive signal that promotes the growth and fasciculation of retinal ganglion cell (RGC) axons, controlling the timing of when RGC axons reach their targets.
Title: DSCAM promotes axon fasciculation and growth in the developing optic pathway.
Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved.
Title: Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:259605 (e-PCR)
- UniSTS:259605

Dscam (e-PCR), detects polymorphism
- UniSTS:259605

RH118366 (e-PCR)
- UniSTS:124295

G67847 (e-PCR)
- UniSTS:228494

G67848 (e-PCR)
- UniSTS:228495

G67849 (e-PCR)
- UniSTS:228496

G67850 (e-PCR)
- UniSTS:228497

G67851 (e-PCR)
- UniSTS:228498

G67852 (e-PCR)
- UniSTS:228499

D16Mit71 (e-PCR), detects polymorphism
- UniSTS:116456

Dscam (e-PCR), detects polymorphism
- UniSTS:259071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables netrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in netrin-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon extension involved in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule DSCAM

Names: Down syndrome cell adhesion molecule homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031174.4 → NP_112451.1 cell adhesion molecule DSCAM precursor

See identical proteins and their annotated locations for NP_112451.1

Status: VALIDATED

Source sequence(s)

AC154387, AC154814, AF315558

Consensus CDS

CCDS37415.1

UniProtKB/Swiss-Prot

Q9ERC8

Related

ENSMUSP00000056040.8, ENSMUST00000056102.9

Conserved Domains (6) summary

cd05734
Location:707 → 784

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:239 → 300

IGc2; Immunoglobulin C-2 Type

smart00410
Location:320 → 400

IG_like; Immunoglobulin like

cd00063
Location:1380 → 1470

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:1301 → 1363

Ig_3; Immunoglobulin domain

cl11960
Location:802 → 889

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

96388652..96971935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522886.4 → XP_006522949.1 cell adhesion molecule DSCAM isoform X1

Conserved Domains (6) summary

cd05734
Location:707 → 784

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:239 → 300

IGc2; Immunoglobulin C-2 Type

smart00409
Location:320 → 400

IG; Immunoglobulin

cd00063
Location:1380 → 1470

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:1301 → 1363

Ig_3; Immunoglobulin domain

cl11960
Location:802 → 889

Ig; Immunoglobulin domain
XM_006522887.4 → XP_006522950.1 cell adhesion molecule DSCAM isoform X4

Conserved Domains (3) summary

cd00063
Location:421 → 511

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:328 → 404

Ig_3; Immunoglobulin domain

cd00096
Location:344 → 348

Ig; Ig strand B [structural motif]
XM_036159772.1 → XP_036015665.1 cell adhesion molecule DSCAM isoform X4

Conserved Domains (3) summary

cd00063
Location:421 → 511

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:328 → 404

Ig_3; Immunoglobulin domain

cd00096
Location:344 → 348

Ig; Ig strand B [structural motif]
XM_030248963.2 → XP_030104823.1 cell adhesion molecule DSCAM isoform X2

Conserved Domains (5) summary

cd05734
Location:198 → 275

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:9 → 66

IGc2; Immunoglobulin C-2 Type

cd00063
Location:871 → 961

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:792 → 854

Ig_3; Immunoglobulin domain

cl11960
Location:293 → 380

Ig; Immunoglobulin domain
XM_036159773.1 → XP_036015666.1 cell adhesion molecule DSCAM isoform X5

Conserved Domains (3) summary

cd00063
Location:421 → 511

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:328 → 404

Ig_3; Immunoglobulin domain

cd00096
Location:344 → 348

Ig; Ig strand B [structural motif]
XM_036159774.1 → XP_036015667.1 cell adhesion molecule DSCAM isoform X5

Conserved Domains (3) summary

cd00063
Location:421 → 511

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:328 → 404

Ig_3; Immunoglobulin domain

cd00096
Location:344 → 348

Ig; Ig strand B [structural motif]
XM_036159771.1 → XP_036015664.1 cell adhesion molecule DSCAM isoform X3

Conserved Domains (6) summary

cd00063
Location:871 → 961

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:778 → 854

Ig_3; Immunoglobulin domain

cd00096
Location:3 → 7

Ig; Ig strand A' [structural motif]

cd05734
Location:180 → 275

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:276 → 375

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:1 → 84

Ig; Immunoglobulin domain