Arid3a AT-rich interaction domain 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arid3aprovided by MGI
Official Full Name: AT-rich interaction domain 3Aprovided by MGI
Primary source: MGI:MGI:1328360
See related: Ensembl:ENSMUSG00000019564 AllianceGenome:MGI:1328360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dri1; Dril1; Bright
Summary: Enables several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and skin. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 13.2), testis adult (RPKM 6.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79762877..79790852)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79927043..79955018)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis.
Title: A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis.
Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm.
Title: Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm.
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.
Title: Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.
Our data show that signals provided by thymic epithelial cells control thymic B cell development by up-regulating Let-7, suppressing Arid3a expression in intrathymic progenitor B cells to limit their proliferation during the neonatal to adult transition.
Title: Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a.
ARID3A is required for normal murine trophoblast development in vivo. The results reveal an essential, conserved function for ARID3A in mammalian placental development through regulation of both intrinsic and extrinsic developmental programs.
Title: ARID3A is required for mammalian placenta development.
identify the Arid3a transcription factor as a key target of Let-7, whose ectopic expression is sufficient to induce B-1 development in adult pro-B cells and whose silencing by knockdown blocks B-1 development in fetal pro-B cells.
Title: Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a.
These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells.
Title: Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells.
identify Arid3a as a critical regulator of TE and placental development through execution of the commitment and differentiation phases of the first cell fate decision
Title: Arid3a is essential to execution of the first cell fate decision via direct embryonic and extraembryonic transcriptional regulation.
These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production
Title: The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.
these results place Bright/Arid3a on a select list of transcriptional regulators required to program both hematopoietic stem cell and lineage-specific differentiation.
Title: The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 3A

Names: ARID domain-containing protein 3A; AT rich interactive domain 3A (BRIGHT-like); AT rich interactive domain 3A (Bright like); B-cell regulator of IgH transcription; dead ringer homolog 1; dead ringer-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001288625.1 → NP_001275554.1 AT-rich interactive domain-containing protein 3A isoform a

See identical proteins and their annotated locations for NP_001275554.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AK141283, BP763961

Consensus CDS

CCDS23999.1

UniProtKB/Swiss-Prot

Q3U338, Q62431, Q80YP8

Related

ENSMUSP00000101015.2, ENSMUST00000105376.2

Conserved Domains (1) summary

cd16878
Location:224 → 356

ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
NM_001288626.1 → NP_001275555.1 AT-rich interactive domain-containing protein 3A isoform b

See identical proteins and their annotated locations for NP_001275555.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 2 aa shorter compared to isoform a.

Source sequence(s)

BC050925, BP763961, BY126533

Consensus CDS

CCDS78851.1

UniProtKB/TrEMBL

A0A0R4J1A7

Related

ENSMUSP00000101016.2, ENSMUST00000105377.8

Conserved Domains (1) summary

smart00501
Location:244 → 336

BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
NM_007880.4 → NP_031906.1 AT-rich interactive domain-containing protein 3A isoform a

See identical proteins and their annotated locations for NP_031906.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AK141283, BC050925, BP763961, BY126533

Consensus CDS

CCDS23999.1

UniProtKB/Swiss-Prot

Q3U338, Q62431, Q80YP8

Related

ENSMUSP00000019708.6, ENSMUST00000019708.12

Conserved Domains (1) summary

cd16878
Location:224 → 356

ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

79762877..79790852

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513202.5 → XP_006513265.1 AT-rich interactive domain-containing protein 3A isoform X1

See identical proteins and their annotated locations for XP_006513265.1

UniProtKB/Swiss-Prot

Q3U338, Q62431, Q80YP8

Conserved Domains (1) summary

cd16878
Location:224 → 356

ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
XM_006513201.5 → XP_006513264.1 AT-rich interactive domain-containing protein 3A isoform X1

See identical proteins and their annotated locations for XP_006513264.1

UniProtKB/Swiss-Prot

Q3U338, Q62431, Q80YP8

Conserved Domains (1) summary

cd16878
Location:224 → 356

ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins