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Dpp6 dipeptidylpeptidase 6 [ Mus musculus (house mouse) ]

Gene ID: 13483, updated on 11-Apr-2024

Summary

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Official Symbol
Dpp6provided by MGI
Official Full Name
dipeptidylpeptidase 6provided by MGI
Primary source
MGI:MGI:94921
See related
Ensembl:ENSMUSG00000061576 AllianceGenome:MGI:94921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rw; Dpp-6; Peplb; D5Buc3; D5Buc4; D5Buc5; DPP VI; Gm1377; In(5)6H-p; B930011P16Rik
Summary
Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant non-syndromic intellectual disability 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 32.7), frontal lobe adult (RPKM 23.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Dpp6 in Genome Data Viewer
Location:
5 B1; 5 12.92 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (27022355..27932498)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (26817357..27727500)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930584F24 gene Neighboring gene STARR-seq mESC enhancer starr_12679 Neighboring gene predicted gene, 34536 Neighboring gene STARR-seq mESC enhancer starr_12680 Neighboring gene STARR-seq mESC enhancer starr_12681 Neighboring gene STARR-seq mESC enhancer starr_12682 Neighboring gene STARR-seq mESC enhancer starr_12683 Neighboring gene STARR-seq mESC enhancer starr_12685 Neighboring gene STARR-seq mESC enhancer starr_12686 Neighboring gene STARR-seq mESC enhancer starr_12689 Neighboring gene Dpp6 Hedgehog-responsive enhancer Neighboring gene nucleoside diphosphate kinase B pseudogene Neighboring gene STARR-seq mESC enhancer starr_12691 Neighboring gene STARR-seq mESC enhancer starr_12692 Neighboring gene STARR-seq mESC enhancer starr_12693 Neighboring gene STARR-seq mESC enhancer starr_12699 Neighboring gene STARR-seq mESC enhancer starr_12703 Neighboring gene STARR-seq mESC enhancer starr_12704 Neighboring gene STARR-seq mESC enhancer starr_12705 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 4B Neighboring gene STARR-seq mESC enhancer starr_12706 Neighboring gene predicted gene 16058 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene predicted gene, 20239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice. Lin L, et al. Neurobiol Dis, 2022 Nov. PMID 36209950, Free PMC Article
  2. A novel structure associated with aging is augmented in the DPP6-KO mouse brain. Lin L, et al. Acta Neuropathol Commun, 2020 Nov 23. PMID 33225987, Free PMC Article
  3. DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory. Lin L, et al. Front Cell Neurosci, 2018. PMID 29651237, Free PMC Article
  4. Expression of DPP6 in Meckel's cartilage and tooth germs during mouse facial development. Du J, et al. Biotech Histochem, 2014 Jan. PMID 23750656
  5. Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. Maffie JK, et al. J Physiol, 2013 May 15. PMID 23440961, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
    Title: Alzheimer's disease/dementia-associated brain pathology in aging DPP6-KO mice.
  2. expression pattern of DPP6 suggests that it may be involved in mandible and tooth development.
    Title: Expression of DPP6 in Meckel's cartilage and tooth germs during mouse facial development.
  3. Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.
    Title: DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.
  4. WT PrP(C), in a DPP6-dependent manner, modulated Kv4.2 channel properties, causing an increase in peak amplitude
    Title: The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.
  5. Findings of this study indicate that an altered response of Kv4/DPP6 to long-term neuroleptic administration is involved in neuroleptic-induced TD.
    Title: DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia.
  6. DPP6 co-expression with TASK-3 results in the formation of a protein complex that enhances resting membrane potassium conductance.
    Title: A new TASK for Dipeptidyl Peptidase-like Protein 6.
  7. the present study described epigenetic silencing of Dpp6 expression by DNA methylation and established that its ectopic expression can act as negative signal during RA induced neuronal differentiation of P19 cells.
    Title: Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells.
  8. In the presence of DPP6 or DPP10, cell surface Kv4.2 protein expression is selectively increased.
    Title: Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.
  9. The expression pattern of Dpp6 suggests that Dpp6 may be involved in embryonic craniofacial development.
    Title: Expression of Dpp6 in mouse embryonic craniofacial development.
  10. The DPP6-E is selectively expressed in a few neuronal populations in brain including cerebellar granule neurons, hippocampal pyramidal cells and neurons in intermediary layers of the superior colliculus.
    Title: A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC113720

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl aminopeptidase-like protein 6
Names
DPPX
dipeptidyl aminopeptidase-related protein
dipeptidyl peptidase IV-like protein
dipeptidyl peptidase VI
dipeptidylpeptidase VI
inversion, Chr 5, Harwell 6, proximal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136060.2 → NP_001129532.1  dipeptidyl aminopeptidase-like protein 6 isoform 1

    See identical proteins and their annotated locations for NP_001129532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (1) is shorter and has a different N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK031903, BC048383, BY127642
    Consensus CDS
    CCDS51447.1
    UniProtKB/TrEMBL
    Q3TY19, Q80VM5
    Related
    ENSMUSP00000099012.4, ENSMUST00000101471.4
    Conserved Domains (2) summary
    pfam00930
    Location:133 → 499
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:583 → 785
    Abhydrolase; alpha/beta hydrolases

  2. NM_001198886.1 → NP_001185815.1  dipeptidyl aminopeptidase-like protein 6 isoform 4

    See identical proteins and their annotated locations for NP_001185815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (4) is shorter and has a different N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK031903, BC085154
    Consensus CDS
    CCDS57332.1
    UniProtKB/TrEMBL
    Q3TY19, Q5U4C2
    Related
    ENSMUSP00000113849.2, ENSMUST00000120555.8
    Conserved Domains (2) summary
    pfam00930
    Location:131 → 497
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:581 → 783
    Abhydrolase; alpha/beta hydrolases

  3. NM_010075.2 → NP_034205.1  dipeptidyl aminopeptidase-like protein 6 isoform 2

    See identical proteins and their annotated locations for NP_034205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate upstream 5' exon, as compared to variant 3. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 3.
    Source sequence(s)
    AF092507, AK031903
    Consensus CDS
    CCDS19139.1
    UniProtKB/Swiss-Prot
    Q9QWW2, Q9Z218, Q9Z219
    UniProtKB/TrEMBL
    Q3TY19
    Related
    ENSMUSP00000071435.7, ENSMUST00000071500.13
    Conserved Domains (2) summary
    pfam00930
    Location:134 → 500
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:584 → 786
    Abhydrolase; alpha/beta hydrolases

  4. NM_207282.3 → NP_997165.2  dipeptidyl aminopeptidase-like protein 6 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AF092507, AK031903, AK158964, BY280444
    Consensus CDS
    CCDS51446.1
    UniProtKB/TrEMBL
    E9PWX1, Q3TY19
    Related
    ENSMUSP00000113441.2, ENSMUST00000122171.8
    Conserved Domains (2) summary
    pfam00930
    Location:189 → 555
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:639 → 841
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    27022355..27932498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z218.1 GenPept UniProtKB/Swiss-Prot:Q9Z218

Gene LinkOut

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