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Dpm2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Mus musculus (house mouse) ]

Gene ID: 13481, updated on 5-Mar-2024

Summary

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Official Symbol
Dpm2provided by MGI
Official Full Name
dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by MGI
Primary source
MGI:MGI:1330238
See related
Ensembl:ENSMUSG00000026810 AllianceGenome:MGI:1330238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to act upstream of or within dolichol metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be integral component of membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to colocalize with endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Iu. Orthologous to human DPM2 (dolichyl-phosphate mannosyltransferase subunit 2, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 57.3), large intestine adult (RPKM 53.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32460870..32463583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32570858..32573571)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene nuclear apoptosis inducing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene RIKEN cDNA 9430097D07 gene Neighboring gene STARR-positive B cell enhancer ABC_E10095 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. Maeda Y, et al. EMBO J, 1998 Sep 1. PMID 9724629, Free PMC Article
  2. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Lennon G, et al. Genomics, 1996 Apr 1. PMID 8617505
  3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
  4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. Dai FF, et al. J Biol Chem, 2015 Oct 9. PMID 26272612, Free PMC Article
  5. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichyl-phosphate beta-D-mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of dolichol-phosphate-mannose synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dolichol-phosphate-mannose synthase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dolichol phosphate-mannose biosynthesis regulatory protein
Names
DPM synthase subunit 2
dolichol-phosphate (beta-D) mannosyltransferase 2
dolichol-phosphate mannose synthase subunit 2
NP_034203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010073.2 → NP_034203.1  dolichol phosphate-mannose biosynthesis regulatory protein

    See identical proteins and their annotated locations for NP_034203.1

    Status: VALIDATED

    Source sequence(s)
    BC008256
    Consensus CDS
    CCDS38104.1
    UniProtKB/Swiss-Prot
    Q9Z324
    UniProtKB/TrEMBL
    Q545R7
    Related
    ENSMUSP00000028151.7, ENSMUST00000028151.7
    Conserved Domains (1) summary
    pfam07297
    Location:5 → 78
    DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32460870..32463583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z324.3 GenPept UniProtKB/Swiss-Prot:Q9Z324

Gene LinkOut

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