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Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 13478, updated on 11-Apr-2024

Summary

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Official Symbol
Dpagt1provided by MGI
Official Full Name
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by MGI
Primary source
MGI:MGI:1196396
See related
Ensembl:ENSMUSG00000032123 AllianceGenome:MGI:1196396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPT; G1PT; Gnpta; Dpagt2
Summary
Enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; dolichol metabolic process; and dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 30.3), ovary adult (RPKM 28.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44237314..44247374)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44325857..44333895)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058 Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene STARR-seq mESC enhancer starr_23963 Neighboring gene H2A.X variant histone Neighboring gene STARR-positive B cell enhancer ABC_E710 Neighboring gene hydroxymethylbilane synthase Neighboring gene VPS11, CORVET/HOPS core subunit Neighboring gene STARR-positive B cell enhancer ABC_E6726

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice. Hyde LF, et al. Int J Mol Sci, 2022 Oct 9. PMID 36233305, Free PMC Article
  2. DPAGT1-Mediated Protein N-Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice. Li H, et al. Adv Sci (Weinh), 2020 Jul. PMID 32714760, Free PMC Article
  3. A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality. Marek KW, et al. Glycobiology, 1999 Nov. PMID 10536042
  4. Negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland. Ma J, et al. J Biol Chem, 1996 May 10. PMID 8626667
  5. Induction of dolichyl-saccharide intermediate biosynthesis corresponds to increased long chain cis-isoprenyltransferase activity during the mitogenic response in mouse B cells. Crick DC, et al. J Biol Chem, 1994 Apr 8. PMID 8144643

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Names
N-acetylglucosamine-1-phosphate transferase
UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2
NP_001351393.1
NP_031901.2
XP_006510054.1
XP_006510055.1
XP_006510058.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364464.1 → NP_001351393.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK008246, BM211613, BM899494, CN665943
    UniProtKB/TrEMBL
    Q9CPT1
    Conserved Domains (1) summary
    cd06855
    Location:1 → 210
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

  2. NM_007875.3 → NP_031901.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1

    See identical proteins and their annotated locations for NP_031901.2

    Status: VALIDATED

    Source sequence(s)
    AC122428, AC124577
    Consensus CDS
    CCDS23104.1
    UniProtKB/Swiss-Prot
    P42867, Q921W5
    Related
    ENSMUSP00000056282.4, ENSMUST00000054708.5
    Conserved Domains (1) summary
    cd06855
    Location:31 → 319
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44237314..44247374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509991.2 → XP_006510054.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

    Conserved Domains (1) summary
    cd06855
    Location:3 → 286
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

  2. XM_006509992.3 → XP_006510055.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

    Conserved Domains (1) summary
    cd06855
    Location:35 → 264
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

  3. XM_006509995.3 → XP_006510058.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

    See identical proteins and their annotated locations for XP_006510058.1

    UniProtKB/TrEMBL
    Q9CPT1
    Conserved Domains (1) summary
    cd06855
    Location:1 → 210
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42867.2 GenPept UniProtKB/Swiss-Prot:P42867

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