Dok1 docking protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dok1provided by MGI
Official Full Name: docking protein 1provided by MGI
Primary source: MGI:MGI:893587
See related: Ensembl:ENSMUSG00000068335 AllianceGenome:MGI:893587
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p62DOK
Summary: Acts upstream of or within Ras protein signal transduction; macrophage colony-stimulating factor signaling pathway; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 9.9), spleen adult (RPKM 9.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83007915..83010448, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83030932..83033495, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis.
Title: Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.
Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling.
Title: Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8(+) T cells and promotes memory formation.
Title: Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.
Title: Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8(+) T Cells in a Murine Model of Ocular Infection.
this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation
Title: Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells.
Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A and IL-22 expression.
Title: Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22.
Dok1 knockdown attenuated TLR2-induced NF-kappaB activation and IL-6 production in microglia.
Title: Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
Triple Dok1 Doc2 Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.
Title: Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Dok-1 overexpression promotes the generation of an innate-like CD8(+) T-cell population that expresses Eomesodermin.
Title: Dok-1 overexpression promotes development of γδ natural killer T cells.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dok1 (e-PCR), detects polymorphism
- UniSTS:142861

AW557123 (e-PCR)
- UniSTS:185673

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within macrophage colony-stimulating factor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: docking protein 1

Names: downstream of tyrosine kinase 1; p62(dok)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409625.1 → NP_001396554.1 docking protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC104324, AC158652
NM_001409626.1 → NP_001396555.1 docking protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC104324, AC158652
NM_010070.5 → NP_034200.4 docking protein 1 isoform 1

See identical proteins and their annotated locations for NP_034200.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC104324, AC158652

Consensus CDS

CCDS20265.1

UniProtKB/Swiss-Prot

P97465, Q9R213

UniProtKB/TrEMBL

Q3UWF9

Related

ENSMUSP00000087079.6, ENSMUST00000089651.6

Conserved Domains (3) summary

cd01203
Location:151 → 253

PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

pfam00169
Location:5 → 116

PH; PH domain

cl17171
Location:6 → 119

PH-like; Pleckstrin homology-like domain

RNA

NR_176878.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC104324, AC158652

Related

ENSMUST00000149918.2
NR_176879.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC104324, AC158652
NR_176880.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC104324, AC158652