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Doc2b double C2, beta [ Mus musculus (house mouse) ]

Gene ID: 13447, updated on 5-Mar-2024

Summary

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Official Symbol
Doc2bprovided by MGI
Official Full Name
double C2, betaprovided by MGI
Primary source
MGI:MGI:1100497
See related
Ensembl:ENSMUSG00000020848 AllianceGenome:MGI:1100497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is a calcium sensor involved in glucose-stimulated insulin secretion, spontaneous neurotransmitter release, and enhanced SNARE-dependent vesicle fusion. [provided by RefSeq, Sep 2015]
Expression
Biased expression in cerebellum adult (RPKM 8.0), adrenal adult (RPKM 5.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 45.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75659096..75686886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75768270..75796060, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene STARR-seq mESC enhancer starr_30008 Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:75790377-75790632 Neighboring gene STARR-positive B cell enhancer ABC_E10691 Neighboring gene ligand of ATE1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer. Adiga D, et al. Pharmacol Res, 2022 Jun. PMID 35500882
  2. Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence. Bhat S, et al. Cell Biol Toxicol, 2022 Apr. PMID 33758996, Free PMC Article
  3. Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. Khan MM, et al. Elife, 2020 Apr 29. PMID 32347796, Free PMC Article
  4. Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function. Aslamy A, et al. Diabetes, 2018 Jul. PMID 29661782, Free PMC Article
  5. Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity. Ramalingam L, et al. Diabetologia, 2014 Jul. PMID 24705606, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOC2B is a negative regulator of Wnt/beta-catenin signaling pathway in cervical cancer.
    Title: DOC2B is a negative regulator of Wnt/β-catenin signaling pathway in cervical cancer.
  2. Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence.
    Title: Metastatic suppression by DOC2B is mediated by inhibition of epithelial-mesenchymal transition and induction of senescence.
  3. Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions.
    Title: Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions.
  4. Doc2b Ca(2+) binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength.
    Title: Doc2b Ca(2+) binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength.
  5. Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons.
    Title: Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons.
  6. DOC2B collaborates with KLC1 to regulate insulin-stimulated GLUT4 accumulation at the plasma membrane and regulates insulin sensitivity
    Title: DOC2B promotes insulin sensitivity in mice via a novel KLC1-dependent mechanism in skeletal muscle.
  7. Doc2alpha promoted glutamatergic spontaneous neurotransmitter release, while Doc2beta and syt1 both regulated GABAergic spontaneous neurotransmitter release.
    Title: Excitatory and Inhibitory Neurons Utilize Different Ca(2+) Sensors and Sources to Regulate Spontaneous Release.
  8. Reduction of DOC2B is an early feature of T1 diabetes (T1D), and DOC2B abundance may serve as a valuable in vivo indicator of beta-cell mass and an early biomarker of T1D.
    Title: Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes.
  9. Doc2b enrichment in the beta-cell protects against diabetogenic and proapoptotic stress.
    Title: Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function.
  10. Mutating Ca(2+)-coordinating aspartates in the C2A-domain localizes Doc2B permanently at the plasma membrane, and renders an upstream priming step Ca(2+)-independent, whereas a separate function in downstream priming depends on SNARE-binding, Ca(2+)-binding to the C2B-domain of Doc2B, interaction with ubMunc13-2 and the presence of synaptotagmin-1.
    Title: Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion-regulated exocytosis of neurotransmitter ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spontaneous neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spontaneous neurotransmitter secretion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spontaneous neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
double C2-like domain-containing protein beta
Names
doc2-beta
double C2 protein beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007873.3 → NP_031899.2  double C2-like domain-containing protein beta

    See identical proteins and their annotated locations for NP_031899.2

    Status: REVIEWED

    Source sequence(s)
    AL669897, BB624126, BC067030
    Consensus CDS
    CCDS25057.1
    UniProtKB/Swiss-Prot
    P70169, Q5SS41, Q6NXK3
    Related
    ENSMUSP00000021209.8, ENSMUST00000021209.8
    Conserved Domains (2) summary
    cd04035
    Location:127 → 250
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:269 → 401
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75659096..75686886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70169.2 GenPept UniProtKB/Swiss-Prot:P70169

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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