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GPR151 G protein-coupled receptor 151 [ Homo sapiens (human) ]

Gene ID: 134391, updated on 11-Apr-2024

Summary

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Official Symbol
GPR151provided by HGNC
Official Full Name
G protein-coupled receptor 151provided by HGNC
Primary source
HGNC:HGNC:23624
See related
Ensembl:ENSG00000173250 MIM:618487; AllianceGenome:HGNC:23624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; PGR7; GALR4; GALRL; GPCR-2037
Summary
This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

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Location:
5q32
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146513144..146516190, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147049016..147052062, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145892707..145895753, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378213 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81818 Neighboring gene Sharpr-MPRA regulatory region 15640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145826559-145827266 Neighboring gene transcription elongation regulator 1 Neighboring gene MPRA-validated peak5524 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:145920194-145920694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:145939738-145940393 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145989281-145989921 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene RNA, 7SL, cytoplasmic 791, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets. Tang XL, et al. Acta Pharmacol Sin, 2012 Mar. PMID 22367282, Free PMC Article
  2. Orphan G-protein-coupled receptors and natural ligand discovery. Howard AD, et al. Trends Pharmacol Sci, 2001 Mar. PMID 11239576
  3. Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. Gurtan A, et al. PLoS Genet, 2022 Apr. PMID 35381001, Free PMC Article
  4. The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. Antolin-Fontes B, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32098843, Free PMC Article
  5. Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain. Holmes FE, et al. Mol Cell Neurosci, 2017 Jan. PMID 27913310, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
    Title: Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.
  2. Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.
    Title: Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors.
  3. These data identify GPR151 as a critical modulator of habenular function that controls nicotine addiction vulnerability
    Title: The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake.
  4. Northern blot analysis reveals expression of galanin-receptor like (GalRL) in the central nervous system with minor levels in peripheral organs and tissues, such as testis, liver, kidney and stomach.
    Title: Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 151
Names
G-protein coupled receptor PGR7
galanin receptor 4
galanin-receptor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194251.3 → NP_919227.2  G-protein coupled receptor 151

    See identical proteins and their annotated locations for NP_919227.2

    Status: VALIDATED

    Source sequence(s)
    AC011375
    Consensus CDS
    CCDS34266.1
    UniProtKB/Swiss-Prot
    Q86SN8, Q8NGV2, Q8TDV0
    Related
    ENSP00000308733.2, ENST00000311104.3
    Conserved Domains (1) summary
    cd15002
    Location:38 → 317
    7tmA_GPR151; G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    146513144..146516190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    147049016..147052062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDV0.1 GenPept UniProtKB/Swiss-Prot:Q8TDV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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