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Dnpep aspartyl aminopeptidase [ Mus musculus (house mouse) ]

Gene ID: 13437, updated on 3-Apr-2024

Summary

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Official Symbol
Dnpepprovided by MGI
Official Full Name
aspartyl aminopeptidaseprovided by MGI
Primary source
MGI:MGI:1278328
See related
Ensembl:ENSMUSG00000026209 AllianceGenome:MGI:1278328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol. Orthologous to human DNPEP (aspartyl aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 135.2), large intestine adult (RPKM 105.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 38.71 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75285209..75294648, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75308565..75317654, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene regulated endocrine-specific protein 18 Neighboring gene VISTA enhancer mm1372 Neighboring gene desmin upstream regulatory region Neighboring gene predicted gene 15179 Neighboring gene desmin Neighboring gene SPEG complex locus

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Koumangoye R, et al. Physiol Rep, 2017 Nov. PMID 29122955, Free PMC Article
  2. Dietary fatty acid composition affects aminopeptidase activities in the testes of mice. Arechaga G, et al. Int J Androl, 2002 Apr. PMID 11903661
  3. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. Wilk S, et al. J Biol Chem, 1998 Jun 26. PMID 9632644
  4. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Nakamura Y, et al. Mol Cell Biol, 2011 Jul. PMID 21576357, Free PMC Article
  5. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Prashar P, et al. Dev Biol, 2014 May 15. PMID 24583261

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that in the absence of aspartyl aminopeptidase (DNPEP), the kidney lysates retain their ability to cleave STE20/SPS1-related proline/alanine-rich kinase(SPAK), indicating that DNPEP might have been misidentified as the protease behind the kidney lysate activity, or that the aspartyl aminopeptidase might not be the only protease cleaving SPAK in kidney.
    Title: DNPEP is not the only peptidase that produces SPAK fragments in kidney.
  2. Results demonstrate that Mir140 is essential for normal endochondral bone development and suggest that the reduced BMP signaling caused by Dnpep upregulation plays a causal role in the skeletal defects of Mir140-null mice.
    Title: Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling.
  3. dietary fatty acids affect activity in mouse testis
    Title: Dietary fatty acid composition affects aminopeptidase activities in the testes of mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aspartyl aminopeptidase
NP_001104301.1
NP_001407066.1
NP_001407067.1
NP_001407068.1
NP_001407069.1
NP_001407070.1
NP_001407071.1
NP_001407072.1
NP_001407073.1
NP_001407074.1
NP_001407075.1
NP_058574.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110831.2 → NP_001104301.1  aspartyl aminopeptidase isoform a

    See identical proteins and their annotated locations for NP_001104301.1

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Consensus CDS
    CCDS78623.1
    UniProtKB/TrEMBL
    Q3TVK3, Q3U3I6, Q8CAJ7
    Related
    ENSMUSP00000140864.2, ENSMUST00000185797.7
    Conserved Domains (1) summary
    pfam02127
    Location:24 → 462
    Peptidase_M18; Aminopeptidase I zinc metalloprotease (M18)

  2. NM_001420137.1 → NP_001407066.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0

  3. NM_001420138.1 → NP_001407067.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0

  4. NM_001420139.1 → NP_001407068.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0

  5. NM_001420140.1 → NP_001407069.1  aspartyl aminopeptidase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0

  6. NM_001420141.1 → NP_001407070.1  aspartyl aminopeptidase isoform c

    Status: VALIDATED

    Source sequence(s)
    AC166150

  7. NM_001420142.1 → NP_001407071.1  aspartyl aminopeptidase isoform d

    Status: VALIDATED

    Source sequence(s)
    AC166150

  8. NM_001420143.1 → NP_001407072.1  aspartyl aminopeptidase isoform e

    Status: VALIDATED

    Source sequence(s)
    AC166150

  9. NM_001420144.1 → NP_001407073.1  aspartyl aminopeptidase isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166150

  10. NM_001420145.1 → NP_001407074.1  aspartyl aminopeptidase isoform f

    Status: VALIDATED

    Source sequence(s)
    AC166150

  11. NM_001420146.1 → NP_001407075.1  aspartyl aminopeptidase isoform g

    Status: VALIDATED

    Source sequence(s)
    AC166150

  12. NM_016878.5 → NP_058574.3  aspartyl aminopeptidase isoform b

    See identical proteins and their annotated locations for NP_058574.3

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Consensus CDS
    CCDS15070.1
    UniProtKB/Swiss-Prot
    Q56A00, Q9Z2W0
    UniProtKB/TrEMBL
    Q3U3I6, Q8CAJ7
    Related
    ENSMUSP00000109235.4, ENSMUST00000113605.10
    Conserved Domains (1) summary
    cd05658
    Location:16 → 461
    M18_DAP; M18 peptidase aspartyl aminopeptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75285209..75294648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2W0.2 GenPept UniProtKB/Swiss-Prot:Q9Z2W0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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