Dnm2 dynamin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnm2provided by MGI
Official Full Name: dynamin 2provided by MGI
Primary source: MGI:MGI:109547
See related: Ensembl:ENSMUSG00000033335 AllianceGenome:MGI:109547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dyn2; Udnm; b2b2159Clo
Summary: Predicted to enable several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in clathrin-coated pit and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; skin; and white fat. Used to study centronuclear myopathy; cystic kidney disease; and myopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 68.5), colon adult (RPKM 65.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.79 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21336167..21419055)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21424908..21507759)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease.
Title: A centronuclear myopathy-causing mutation in dynamin-2 disrupts neuronal morphology and excitatory synaptic transmission in a murine model of the disease.
Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies.
Title: Tamoxifen improves muscle structure and function of Bin1- and Dnm2-related centronuclear myopathies.
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Title: BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice.
Title: Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice.
GSK3alpha phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
Title: GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.
Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.
Title: Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.
Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Title: Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
Title: Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.
Title: Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.
A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes.
Title: A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (11) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in Golgi to plasma membrane transport	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in macropinocytosis	ISO Inferred from Sequence Orthology more info
involved_in membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle scission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
colocalizes_with growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynamin-2

NP_001034609.1

EC 3.6.5.5

NP_001240822.1

EC 3.6.5.5

NP_001240823.1

EC 3.6.5.5

NP_001344647.1

EC 3.6.5.5

NP_001344648.1

EC 3.6.5.5

NP_001344650.1

EC 3.6.5.5

NP_031897.2

EC 3.6.5.5

XP_006510036.1

EC 3.6.5.5

XP_006510037.1

EC 3.6.5.5

XP_006510039.1

EC 3.6.5.5

XP_006510042.1

EC 3.6.5.5

XP_006510043.1

EC 3.6.5.5

XP_006510044.1

EC 3.6.5.5

XP_017168616.1

EC 3.6.5.5

XP_017168617.1

EC 3.6.5.5

XP_030099903.1

EC 3.6.5.5

XP_030099904.1

EC 3.6.5.5

XP_030099905.1

EC 3.6.5.5

XP_030099906.1

EC 3.6.5.5

XP_036010492.1

EC 3.6.5.5

XP_036010493.1

EC 3.6.5.5

XP_036010494.1

EC 3.6.5.5

XP_036010495.1

EC 3.6.5.5

XP_036010496.1

EC 3.6.5.5

XP_036010497.1

EC 3.6.5.5

XP_036010498.1

EC 3.6.5.5

XP_036010499.1

EC 3.6.5.5

XP_036010500.1

EC 3.6.5.5

XP_036010501.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039520.2 → NP_001034609.1 dynamin-2 isoform 2

See identical proteins and their annotated locations for NP_001034609.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AA221527, AK157844, AK171566, BY275016

Consensus CDS

CCDS57660.1

UniProtKB/TrEMBL

Q3TBU6, Q3TCR7

Related

ENSMUSP00000134243.2, ENSMUST00000173397.8

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:745 → 865

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
NM_001253893.1 → NP_001240822.1 dynamin-2 isoform 1

See identical proteins and their annotated locations for NP_001240822.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest variant and it encodes the longest protein (isoform 1).

Source sequence(s)

AA221527, AK005012, AK150046, AK157844, BY275016, BY549643

Consensus CDS

CCDS57657.1

UniProtKB/Swiss-Prot

P39054, Q9DBE1

UniProtKB/TrEMBL

F8WIV5

Related

ENSMUSP00000133564.2, ENSMUST00000172482.8

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 868

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
NM_001253894.1 → NP_001240823.1 dynamin-2 isoform 4

See identical proteins and their annotated locations for NP_001240823.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate 3' terminal exon compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK005012, BQ031151, BY275016, CD540553

Consensus CDS

CCDS57658.1

UniProtKB/TrEMBL

F8WIV5, Q3T9X3

Related

ENSMUSP00000128961.3, ENSMUST00000165766.9

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 836

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
NM_001357718.1 → NP_001344647.1 dynamin-2 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini and the same length but differs in an internal segment compared to isoform 1.

Source sequence(s)

AC163748

Consensus CDS

CCDS90515.1

UniProtKB/TrEMBL

G3X9G4, Q3TBU6

Related

ENSMUSP00000072199.8, ENSMUST00000072362.14

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 868

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
NM_001357719.1 → NP_001344648.1 dynamin-2 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC163748

UniProtKB/TrEMBL

F8WIV5

Related

ENSMUSP00000134696.2, ENSMUST00000174050.8

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 832

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain
NM_001357721.1 → NP_001344650.1 dynamin-2 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two alternate exons, contains another alternate exon, and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (7) lacks an alternate internal segment, differs in another internal segment, and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC163748

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 832

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain
NM_007871.2 → NP_031897.2 dynamin-2 isoform 3

See identical proteins and their annotated locations for NP_031897.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AA221527, AK005012, AK157844, BY275016, BY549643

Consensus CDS

CCDS57659.1

UniProtKB/TrEMBL

F8WIV5

Related

ENSMUSP00000088616.7, ENSMUST00000091087.13

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 864

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

21336167..21419055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154602.1 → XP_036010495.1 dynamin-2 isoform X7

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:747 → 846

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:530 → 639

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:661 → 749

GED; Dynamin GTPase effector domain
XM_036154603.1 → XP_036010496.1 dynamin-2 isoform X10

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:743 → 842

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:524 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:657 → 745

GED; Dynamin GTPase effector domain
XM_006509981.4 → XP_006510044.1 dynamin-2 isoform X13

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:737 → 836

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
XM_006509976.4 → XP_006510039.1 dynamin-2 isoform X5

UniProtKB/TrEMBL

F8WIV5

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:743 → 874

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:524 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:656 → 745

GED; Dynamin GTPase effector domain
XM_017313127.3 → XP_017168616.1 dynamin-2 isoform X12

UniProtKB/TrEMBL

F8WIV5

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:741 → 861

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain
XM_036154600.1 → XP_036010493.1 dynamin-2 isoform X4

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:743 → 874

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:524 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:657 → 745

GED; Dynamin GTPase effector domain
XM_036154601.1 → XP_036010494.1 dynamin-2 isoform X6

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:751 → 871

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:524 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:657 → 745

GED; Dynamin GTPase effector domain
XM_006509980.4 → XP_006510043.1 dynamin-2 isoform X9

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:733 → 864

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain
XM_017313128.3 → XP_017168617.1 dynamin-2 isoform X11

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:741 → 861

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:646 → 735

GED; Dynamin GTPase effector domain
XM_006509973.3 → XP_006510036.1 dynamin-2 isoform X2

UniProtKB/TrEMBL

F8WIV5

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:747 → 878

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:530 → 639

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:660 → 749

GED; Dynamin GTPase effector domain
XM_006509979.3 → XP_006510042.1 dynamin-2 isoform X8

UniProtKB/TrEMBL

F8WIV5

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:745 → 865

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:520 → 629

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
XM_006509974.3 → XP_006510037.1 dynamin-2 isoform X1

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:747 → 878

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:530 → 639

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:660 → 749

GED; Dynamin GTPase effector domain
XM_036154599.1 → XP_036010492.1 dynamin-2 isoform X3

UniProtKB/TrEMBL

Q3TBU6

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PRK14951
Location:755 → 875

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:530 → 639

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region

pfam02212
Location:661 → 749

GED; Dynamin GTPase effector domain
XM_036154604.1 → XP_036010497.1 dynamin-2 isoform X18

UniProtKB/TrEMBL

Q9CUM4

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region
XM_030244046.2 → XP_030099906.1 dynamin-2 isoform X17

UniProtKB/TrEMBL

G3UZZ3

Conserved Domains (5) summary

PHA03247
Location:575 → 674

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:356 → 467

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:58 → 344

Dynamin_M; Dynamin central region

pfam02212
Location:488 → 577

GED; Dynamin GTPase effector domain

cl38985
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030244045.2 → XP_030099905.1 dynamin-2 isoform X16

UniProtKB/TrEMBL

G3UZZ3

Conserved Domains (5) summary

PHA03247
Location:575 → 706

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:356 → 467

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:58 → 344

Dynamin_M; Dynamin central region

pfam02212
Location:488 → 577

GED; Dynamin GTPase effector domain

cl38985
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030244043.2 → XP_030099903.1 dynamin-2 isoform X14

UniProtKB/TrEMBL

G3UZZ3

Conserved Domains (5) summary

PHA03247
Location:589 → 720

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:372 → 481

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:58 → 340

Dynamin_M; Dynamin central region

pfam02212
Location:502 → 591

GED; Dynamin GTPase effector domain

cl38985
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030244044.2 → XP_030099904.1 dynamin-2 isoform X15

UniProtKB/TrEMBL

G3UZZ3

Conserved Domains (5) summary

PHA03247
Location:579 → 710

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:362 → 471

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:58 → 344

Dynamin_M; Dynamin central region

pfam02212
Location:492 → 581

GED; Dynamin GTPase effector domain

cl38985
Location:1 → 87

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036154605.1 → XP_036010498.1 dynamin-2 isoform X19

UniProtKB/TrEMBL

Q91Z39

Conserved Domains (4) summary

PHA03247
Location:341 → 472

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:124 → 233

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:1 → 92

Dynamin_M; Dynamin central region

pfam02212
Location:255 → 343

GED; Dynamin GTPase effector domain
XM_036154607.1 → XP_036010500.1 dynamin-2 isoform X21

UniProtKB/TrEMBL

Q91Z39

Conserved Domains (4) summary

PRK14951
Location:335 → 455

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd01256
Location:108 → 219

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:1 → 96

Dynamin_M; Dynamin central region

pfam02212
Location:241 → 329

GED; Dynamin GTPase effector domain
XM_036154606.1 → XP_036010499.1 dynamin-2 isoform X20

UniProtKB/TrEMBL

Q91Z39

Conserved Domains (4) summary

PHA03247
Location:331 → 462

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:114 → 223

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:1 → 96

Dynamin_M; Dynamin central region

pfam02212
Location:245 → 333

GED; Dynamin GTPase effector domain
XM_036154608.1 → XP_036010501.1 dynamin-2 isoform X22

UniProtKB/TrEMBL

Q91Z39

Conserved Domains (4) summary

PHA03247
Location:341 → 440

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:124 → 233

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:2 → 106

Dynamin_M; Dynamin central region

pfam02212
Location:255 → 343

GED; Dynamin GTPase effector domain