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Dnm1 dynamin 1 [ Mus musculus (house mouse) ]

Gene ID: 13429, updated on 11-Apr-2024

Summary

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Official Symbol
Dnm1provided by MGI
Official Full Name
dynamin 1provided by MGI
Primary source
MGI:MGI:107384
See related
Ensembl:ENSMUSG00000026825 AllianceGenome:MGI:107384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnm; Ftfl; mKIAA4093
Summary
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Biased expression in cerebellum adult (RPKM 188.3), cortex adult (RPKM 160.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 22.09 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32198483..32243361, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32308471..32353349, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SWI5 recombination repair homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E9197 Neighboring gene golgin A2 Neighboring gene microRNA 3154 Neighboring gene microRNA 199b Neighboring gene predicted gene, 52590 Neighboring gene predicted gene, 39787

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Altered Fast Synaptic Transmission in a Mouse Model of DNM1-Associated Developmental Epileptic Encephalopathy. McCabe MP, et al. eNeuro, 2021 Mar-Apr. PMID 33372033, Free PMC Article
  2. Overlaps, gaps, and complexities of mouse models of Developmental and Epileptic Encephalopathy. Wang W, et al. Neurobiol Dis, 2021 Jan. PMID 33301879, Free PMC Article
  3. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells. Wu Q, et al. J Neurosci, 2019 Jan 9. PMID 30381405, Free PMC Article
  4. Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory. Yoo DY, et al. Mol Med Rep, 2016 Nov. PMID 27748822
  5. 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target? Kim JY, et al. Stroke, 2016 Aug. PMID 27387989, Free PMC Article

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.
    Title: Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.
  2. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway.
    Title: Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway.
  3. The present work with dyn1-KO mice further confirms that Ca(2+)-dependent transmitter release is mainly via subquantal mode, suggesting that subquantal release could be also important in other types of cells
    Title: Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells.
  4. Cellular fluorescein hyperfluorescence is dynamin-dependent.
    Title: Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment.
  5. dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis
    Title: A multiscale study of the role of dynamin in the regulation of glucose uptake.
  6. reveal functional differences between Dnm1a and Dnm1b isoforms in the presence of a challenge, i.e. toxic Dnm1(Ftfl), while reinforcing its effect explicitly in this model of severe pediatric epilepsy
    Title: Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
  7. in the mature epididymis, predominantly localized in clear cells of the distal segments
    Title: Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.
  8. Dynamin may facilitate Fas-mediated apoptotic death in the brain, and Hsp70 may protect by preventing this trafficking.
    Title: 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
  9. These results suggested that dynamin 1 was susceptible to the aging process, and that a reduction in dynamin 1 may result in hippocampaldependent memory deficits by disrupting endocytosis and the release of neurotransmitters.
    Title: Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory.
  10. Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.
    Title: Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4093

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly involved in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vesicle size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle scission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath HDA PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic endocytic zone membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in varicosity ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynamin-1
Names
dynamin I
NP_001288666.1
NP_001355608.1
NP_034195.2
XP_006497712.2
XP_006497713.2
XP_006497716.2
XP_006497717.2
XP_006497718.2
XP_006497721.2
XP_006497722.2
XP_006497723.2
XP_006497724.2
XP_006497725.1
XP_017170817.1
XP_036013974.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301737.1 → NP_001288666.1  dynamin-1 isoform 2

    See identical proteins and their annotated locations for NP_001288666.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant contains the alternate "a" exon in the central coding region and the "b" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AK011651, AL808027, BC034679, BQ179370, BY297150, CA328097, CO425806
    Consensus CDS
    CCDS79772.1
    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Related
    ENSMUSP00000077461.6, ENSMUST00000078352.12
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  2. NM_001368679.1 → NP_001355608.1  dynamin-1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons in the mid-coding region and uses an alternate acceptor splice site at the 3' terminal exon compared to variant one. The resulting isoform (3) is longer than isoform 1.
    Source sequence(s)
    AL808027
    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 863
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656 → 745
    GED; Dynamin GTPase effector domain

  3. NM_010065.3 → NP_034195.2  dynamin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This variant contains the alternate "b" exon in the central coding region and the "a" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
    Source sequence(s)
    AA387428, AI894003, AK011651, BC058623, BE860433, BM950315, BY297150, CX239206
    Consensus CDS
    CCDS38102.1
    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Related
    ENSMUSP00000088618.6, ENSMUST00000091089.12
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 501
    Dynamin_M; Dynamin central region
    pfam02212
    Location:653 → 741
    GED; Dynamin GTPase effector domain
    cl26464
    Location:743 → 860
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_125959.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains two alternate exons in the central region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant contains the alternate "b" exon in the central region (PMID:20700442).
    Source sequence(s)
    BC034679, BY297150
    Related
    ENSMUST00000139624.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32198483..32243361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497654.4 → XP_006497717.2  dynamin-1 isoform X4

    See identical proteins and their annotated locations for XP_006497717.2

    UniProtKB/TrEMBL
    A0A0J9YUE9, A0A0J9YUN4
    Related
    ENSMUSP00000144264.2, ENSMUST00000201433.4
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  2. XM_006497649.3 → XP_006497712.2  dynamin-1 isoform X1

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656 → 745
    GED; Dynamin GTPase effector domain

  3. XM_006497659.4 → XP_006497722.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497722.2

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  4. XM_006497655.4 → XP_006497718.2  dynamin-1 isoform X5

    UniProtKB/TrEMBL
    A0A0J9YUE9
    Related
    ENSMUSP00000108992.2, ENSMUST00000113365.8
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  5. XM_036158081.1 → XP_036013974.1  dynamin-1 isoform X3

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 863
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  6. XM_006497661.3 → XP_006497724.2  dynamin-1 isoform X8

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Related
    ENSMUSP00000108977.2, ENSMUST00000113350.8
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  7. XM_006497653.4 → XP_006497716.2  dynamin-1 isoform X6

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:743 → 860
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:652 → 741
    GED; Dynamin GTPase effector domain

  8. XM_006497658.4 → XP_006497721.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497721.2

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Related
    ENSMUSP00000143955.2, ENSMUST00000202578.4
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  9. XM_006497650.4 → XP_006497713.2  dynamin-1 isoform X2

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:656 → 745
    GED; Dynamin GTPase effector domain

  10. XM_017315328.2 → XP_017170817.1  dynamin-1 isoform X8

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Related
    ENSMUSP00000108979.3, ENSMUST00000113352.9
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  11. XM_006497662.3 → XP_006497725.1  dynamin-1 isoform X9

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    cd08771
    Location:100 → 340
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    PHA03247
    Location:793 → 910
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:566 → 675
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:262 → 548
    Dynamin_M; Dynamin central region
    pfam02212
    Location:702 → 791
    GED; Dynamin GTPase effector domain

  12. XM_006497660.3 → XP_006497723.2  dynamin-1 isoform X7

    See identical proteins and their annotated locations for XP_006497723.2

    UniProtKB/Swiss-Prot
    A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

RNA

  1. XR_374055.3 RNA Sequence

  2. XR_004938046.1 RNA Sequence

  3. XR_001780675.2 RNA Sequence

  4. XR_004938043.1 RNA Sequence

  5. XR_004938042.1 RNA Sequence

  6. XR_004938044.1 RNA Sequence

  7. XR_374058.5 RNA Sequence

  8. XR_374057.4 RNA Sequence

  9. XR_001780678.3 RNA Sequence

  10. XR_003950433.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39053.2 GenPept UniProtKB/Swiss-Prot:P39053

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