Dnase1l3 deoxyribonuclease 1-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnase1l3provided by MGI
Official Full Name: deoxyribonuclease 1-like 3provided by MGI
Primary source: MGI:MGI:1314633
See related: Ensembl:ENSMUSG00000025279 AllianceGenome:MGI:1314633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lsd; Dhp2; DNasegamma
Summary: Enables endonuclease activity. Involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Acts upstream of or within apoptotic DNA fragmentation and programmed cell death involved in cell development. Located in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1 like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 37.6), liver adult (RPKM 10.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 4.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (14475014..14504586)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (7965187..7994760, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice.
Title: Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice.
DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer.
Title: DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer.
B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice.
Title: B cell-intrinsic DNase1L3 is essential for the T cell-independent type II response in mice.
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Title: Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
Title: Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Title: Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase.
Title: Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase.
These results support a distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity.
Title: Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA.
DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps.
Title: Host DNases prevent vascular occlusion by neutrophil extracellular traps.
Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response.
Title: Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in programmed cell death involved in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within programmed cell death involved in cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neutrophil mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deoxyribonuclease gamma

Names: DNase I homolog protein DHP2; DNase I-like 3; DNase gamma; LS-DNase; deoxyribonuclease I-like 3; liver and spleen DNase; macrophage specific DNase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.