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LSMEM2 leucine rich single-pass membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 132228, updated on 5-Mar-2024

Summary

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Official Symbol
LSMEM2provided by HGNC
Official Full Name
leucine rich single-pass membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:26781
See related
Ensembl:ENSG00000179564 AllianceGenome:HGNC:26781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf45
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 6.3), prostate (RPKM 1.9) and 25 other tissues See more
Orthologs
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Genomic context

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See LSMEM2 in Genome Data Viewer
Location:
3p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50277907..50288114)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50307257..50317471)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50316518..50325545)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SEMA3B antisense RNA 1 (head to head) Neighboring gene semaphorin 3B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19897 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50310784-50311307 Neighboring gene microRNA 6872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14390 Neighboring gene interferon related developmental regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50330739-50331294 Neighboring gene hyaluronidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19899 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50340489-50341423 Neighboring gene hyaluronidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. Kim JS, et al. J Biol Chem, 2019 May 31. PMID 31010829, Free PMC Article
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich single-pass membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304385.2 → NP_001291314.1  leucine-rich single-pass membrane protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC028000, DA830939, U90094
    UniProtKB/Swiss-Prot
    Q8N112
    Conserved Domains (1) summary
    pfam15833
    Location:13 → 161
    DUF4714; Domain of unknown function (DUF4714)

  2. NM_153215.3 → NP_694947.1  leucine-rich single-pass membrane protein 2 isoform 1

    See identical proteins and their annotated locations for NP_694947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC028000, U90094
    Consensus CDS
    CCDS2814.1
    UniProtKB/Swiss-Prot
    Q8N112
    Related
    ENSP00000315081.3, ENST00000316436.4
    Conserved Domains (1) summary
    pfam15833
    Location:14 → 162
    DUF4714; Domain of unknown function (DUF4714)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    50277907..50288114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533370.4 → XP_011531672.1  leucine-rich single-pass membrane protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011531672.1

    Conserved Domains (1) summary
    pfam15833
    Location:1 → 138
    DUF4714; Domain of unknown function (DUF4714)

  2. XM_006712979.5 → XP_006713042.1  leucine-rich single-pass membrane protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15833
    Location:29 → 171
    DUF4714; Domain of unknown function (DUF4714)

  3. XM_006712980.5 → XP_006713043.1  leucine-rich single-pass membrane protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15833
    Location:29 → 170
    DUF4714; Domain of unknown function (DUF4714)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    50307257..50317471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345294.1 → XP_054201269.1  leucine-rich single-pass membrane protein 2 isoform X3

  2. XM_054345292.1 → XP_054201267.1  leucine-rich single-pass membrane protein 2 isoform X1

  3. XM_054345293.1 → XP_054201268.1  leucine-rich single-pass membrane protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N112.1 GenPept UniProtKB/Swiss-Prot:Q8N112

Gene LinkOut

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