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IQCF1 IQ motif containing F1 [ Homo sapiens (human) ]

Gene ID: 132141, updated on 5-Mar-2024

Summary

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Official Symbol
IQCF1provided by HGNC
Official Full Name
IQ motif containing F1provided by HGNC
Primary source
HGNC:HGNC:28607
See related
Ensembl:ENSG00000173389 AllianceGenome:HGNC:28607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 24.8) See more
Orthologs
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Genomic context

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See IQCF1 in Genome Data Viewer
Location:
3p21.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51894876..51903353, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51927807..51936279, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51928892..51937369, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 504, pseudogene Neighboring gene IQCF5 antisense RNA 1 Neighboring gene IQ motif containing F5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:51935927-51937126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:51975282-51975930 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19921 Neighboring gene poly(ADP-ribose) polymerase family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Fang P, et al. Andrology, 2015 Mar. PMID 25380116
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ27508, MGC39725

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of flagellated sperm motility involved in capacitation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
IQ domain-containing protein F1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152397.3 → NP_689610.2  IQ domain-containing protein F1

    See identical proteins and their annotated locations for NP_689610.2

    Status: VALIDATED

    Source sequence(s)
    AC097636, BC029595
    Consensus CDS
    CCDS2836.1
    UniProtKB/Swiss-Prot
    Q8N6M8, Q8N711
    Related
    ENSP00000307958.5, ENST00000310914.10
    Conserved Domains (1) summary
    pfam11374
    Location:86 → 143
    DUF3176; Protein of unknown function (DUF3176)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51894876..51903353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005729.1 → XP_016861218.1  IQ domain-containing protein F1 isoform X1

    Conserved Domains (1) summary
    pfam11374
    Location:51 → 108
    DUF3176; Protein of unknown function (DUF3176)

  2. XM_011533366.2 → XP_011531668.1  IQ domain-containing protein F1 isoform X2

    See identical proteins and their annotated locations for XP_011531668.1

    Conserved Domains (1) summary
    pfam11374
    Location:51 → 108
    DUF3176; Protein of unknown function (DUF3176)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51927807..51936279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345278.1 → XP_054201253.1  IQ domain-containing protein F1 isoform X1

  2. XM_054345279.1 → XP_054201254.1  IQ domain-containing protein F1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6M8.2 GenPept UniProtKB/Swiss-Prot:Q8N6M8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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