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Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain1 [ Mus musculus (house mouse) ]

Gene ID: 13196, updated on 3-Apr-2024

Summary

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Official Symbol
Asap1provided by MGI
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain1provided by MGI
Primary source
MGI:MGI:1342335
See related
Ensembl:ENSMUSG00000022377 AllianceGenome:MGI:1342335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAP; s19; DEF-1; Ddef1; mKIAA1249
Summary
Enables GTPase activator activity; SH3 domain binding activity; and phospholipid binding activity. Acts upstream of or within negative regulation of dendritic spine development; positive regulation of membrane tubulation; and positive regulation of podosome assembly. Located in cell projection membrane; dendritic spine; and podosome. Is active in cytosol and plasma membrane. Is expressed in several structures, including gonad; limb; long bone; perichondrium; and thoracic duct. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 21.3), cortex adult (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 28.55 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63958704..64254922, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (64086840..64382941, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C-like, pseudogene Neighboring gene CYFIP related Rac1 interactor B Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene STARR-seq mESC enhancer starr_38849 Neighboring gene STARR-positive B cell enhancer ABC_E10857 Neighboring gene STARR-positive B cell enhancer ABC_E9912 Neighboring gene predicted gene, 25628 Neighboring gene STARR-positive B cell enhancer ABC_E1906 Neighboring gene predicted gene 20717 Neighboring gene STARR-seq mESC enhancer starr_38853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:64017486-64017639 Neighboring gene STARR-seq mESC enhancer starr_38854 Neighboring gene VISTA enhancer mm1716 Neighboring gene STARR-seq mESC enhancer starr_38855 Neighboring gene RIKEN cDNA 1700010G06 gene Neighboring gene STARR-seq mESC enhancer starr_38857 Neighboring gene predicted gene, 30563 Neighboring gene predicted gene, 46509

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide. Haque A, et al. Cancer Immunol Immunother, 2011 Oct. PMID 21644032
  2. Erythroblast differentiation at spleen in Q137E mutant ribosomal protein S19 gene knock-in C57BL/6J mice. Yamanegi K, et al. Immunobiology, 2018 Jan. PMID 29017823
  3. The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network. Chen PW, et al. J Biol Chem, 2016 Apr 1. PMID 26893376, Free PMC Article
  4. A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. Sheridan JM, et al. BMC Cancer, 2015 Apr 3. PMID 25879659, Free PMC Article
  5. The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting. Wang J, et al. EMBO J, 2012 Oct 17. PMID 22983554, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
    Title: miR-212/132 attenuates OVA-induced airway inflammation by inhibiting mast cells activation through MRGPRX2 and ASAP1.
  2. Together these observations suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells
    Title: Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
  3. these data indicated that ribosomal protein S19 polymer plays the roles in the early erythroblast differentiation of C57BL/6J mouse spleen
    Title: Erythroblast differentiation at spleen in Q137E mutant ribosomal protein S19 gene knock-in C57BL/6J mice.
  4. results support the hypothesis that ASAP1 is a positive regulator of NM2A.
    Title: The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.
  5. we demonstrate that Prox1 and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
    Title: A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.
  6. ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.
    Title: The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.
  7. ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS)-induced proinflammatory mediators production through down-regulating LPS signaling
    Title: An ADP ribosylation factor-GTPase activating protein negatively regulates the production of proinflammatory mediators in response to lipopolysaccharide.
  8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
    Title: ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
  9. ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src.
    Title: Src-dependent phosphorylation of ASAP1 regulates podosomes.
  10. DEF-1 alters cell motility through the deactivation of ARF1. In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
    Title: DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in podosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Names
130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
ADP-ribosylation factor-directed GTPase-activating protein 1
ARF GTPase-activating protein 1
PIP2-dependent ARF1 GAP
development and differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276461.2 → NP_001263390.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC098728, AC131710, AC156573
    Consensus CDS
    CCDS70633.1
    UniProtKB/TrEMBL
    H3BKE6, Q3UJA5
    Related
    ENSMUSP00000135359.2, ENSMUST00000175799.8
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1029 → 1085
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:739 → 1018
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:328 → 434
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:613 → 646
    ANK; ANK repeat [structural motif]
    cd08848
    Location:449 → 570
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:617 → 689
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001276462.2 → NP_001263391.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC131710, AC156573
    Consensus CDS
    CCDS70631.1
    UniProtKB/TrEMBL
    E9QN63, H3BL41
    Related
    ENSMUSP00000135643.2, ENSMUST00000177371.8
    Conserved Domains (7) summary
    cd07641
    Location:34 → 248
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1066 → 1122
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:717 → 1055
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:308 → 414
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:593 → 626
    ANK; ANK repeat [structural motif]
    cd08848
    Location:429 → 550
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:597 → 669
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001276463.2 → NP_001263392.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC131710, AC156573
    Consensus CDS
    CCDS70632.1
    UniProtKB/TrEMBL
    E9QMJ1, E9QN63
    Related
    ENSMUSP00000134877.2, ENSMUST00000177083.8
    Conserved Domains (7) summary
    cd07641
    Location:34 → 248
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1054 → 1110
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:705 → 1043
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:296 → 402
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:581 → 614
    ANK; ANK repeat [structural motif]
    cd08848
    Location:417 → 538
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:585 → 657
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001276467.2 → NP_001263396.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC098728, AC131710, AC156573
    Consensus CDS
    CCDS70634.1
    UniProtKB/TrEMBL
    E9QMI7
    Related
    ENSMUSP00000135190.2, ENSMUST00000176384.8
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1032 → 1088
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:742 → 1021
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:331 → 437
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:616 → 649
    ANK; ANK repeat [structural motif]
    cd08848
    Location:452 → 573
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:620 → 692
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001411185.1 → NP_001398114.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC098728, AC131710, AC156573
    Related
    ENSMUSP00000105742.3, ENSMUST00000110115.9

  6. NM_010026.4 → NP_034156.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_034156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC098728, AC131710, AC156573
    Consensus CDS
    CCDS56986.1
    UniProtKB/Swiss-Prot
    O08612, Q505F0, Q80TG8, Q80UV6, Q99LV8, Q9QWY8, Q9Z2B6
    UniProtKB/TrEMBL
    E9QN63
    Related
    ENSMUSP00000134825.2, ENSMUST00000177374.8
    Conserved Domains (9) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1089 → 1145
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:616 → 704
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:331 → 437
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:341 → 426
    PH; PH domain
    pfam01412
    Location:454 → 570
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:597 → 682
    Ank_2; Ankyrin repeats (3 copies)
    pfam16638
    Location:931 → 1013
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    sd00045
    Location:616 → 649
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63958704..64254922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159121.1 → XP_036015014.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    H3BKD4, Q3UJA5
    Related
    ENSMUSP00000135346.2, ENSMUST00000177035.8
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1017 → 1073
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:727 → 1006
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:316 → 422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601 → 634
    ANK; ANK repeat [structural motif]
    cd08848
    Location:437 → 558
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:605 → 677
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036159120.1 → XP_036015013.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

    UniProtKB/TrEMBL
    E9QMI7
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1020 → 1076
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:730 → 1009
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604 → 637
    ANK; ANK repeat [structural motif]
    cd08848
    Location:440 → 561
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:608 → 680
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036159117.1 → XP_036015010.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    E9QN63
    Related
    ENSMUSP00000135718.2, ENSMUST00000175793.8
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1077 → 1133
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:728 → 1066
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:319 → 425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604 → 637
    ANK; ANK repeat [structural motif]
    cd08848
    Location:440 → 561
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:608 → 680
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036159116.1 → XP_036015009.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    E9QN63, H3BJY2
    Related
    ENSMUSP00000135172.2, ENSMUST00000176014.8
    Conserved Domains (7) summary
    cd07641
    Location:54 → 268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1086 → 1142
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:737 → 1075
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:328 → 434
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:613 → 646
    ANK; ANK repeat [structural motif]
    cd08848
    Location:449 → 570
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:617 → 689
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036159119.1 → XP_036015012.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd11965
    Location:1030 → 1086
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:681 → 1019
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:272 → 378
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:557 → 590
    ANK; ANK repeat [structural motif]
    cd08848
    Location:393 → 514
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:561 → 633
    Ank_2; Ankyrin repeats (3 copies)
    cl12013
    Location:1 → 209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_006520395.2 → XP_006520458.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd07641
    Location:138 → 344
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1150 → 1206
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd13251
    Location:392 → 498
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:677 → 710
    ANK; ANK repeat [structural motif]
    cd08848
    Location:513 → 634
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam03154
    Location:830 → 1094
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:681 → 753
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_006520394.2 → XP_006520457.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd07641
    Location:138 → 344
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1153 → 1209
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd13251
    Location:395 → 501
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:680 → 713
    ANK; ANK repeat [structural motif]
    cd08848
    Location:516 → 637
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam03154
    Location:833 → 1097
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:684 → 756
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_036159115.1 → XP_036015008.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3UJA5
    Conserved Domains (7) summary
    cd11965
    Location:1105 → 1161
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:815 → 1094
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:404 → 510
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:689 → 722
    ANK; ANK repeat [structural motif]
    cd08848
    Location:525 → 646
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:693 → 765
    Ank_2; Ankyrin repeats (3 copies)
    cl12013
    Location:138 → 344
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_006520393.2 → XP_006520456.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd07641
    Location:138 → 344
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1162 → 1218
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd13251
    Location:404 → 510
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:689 → 722
    ANK; ANK repeat [structural motif]
    cd08848
    Location:525 → 646
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam03154
    Location:842 → 1106
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:693 → 765
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_006520397.2 → XP_006520460.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    E9QMI7
    Conserved Domains (7) summary
    cd11965
    Location:1108 → 1164
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:818 → 1097
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:407 → 513
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:692 → 725
    ANK; ANK repeat [structural motif]
    cd08848
    Location:528 → 649
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:696 → 768
    Ank_2; Ankyrin repeats (3 copies)
    cl12013
    Location:138 → 344
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_006520392.2 → XP_006520455.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd07641
    Location:138 → 344
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1165 → 1221
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd13251
    Location:407 → 513
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:692 → 725
    ANK; ANK repeat [structural motif]
    cd08848
    Location:528 → 649
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam03154
    Location:845 → 1109
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:696 → 768
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_036159118.1 → XP_036015011.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd07641
    Location:34 → 248
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:1069 → 1125
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    PHA03247
    Location:720 → 1058
    PHA03247; large tegument protein UL36; Provisional
    cd13251
    Location:311 → 417
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:596 → 629
    ANK; ANK repeat [structural motif]
    cd08848
    Location:432 → 553
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam12796
    Location:600 → 672
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_011245448.1 → XP_011243750.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    E9QN63
    Conserved Domains (7) summary
    cd11965
    Location:1038 → 1094
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd13251
    Location:280 → 386
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:565 → 598
    ANK; ANK repeat [structural motif]
    cd08848
    Location:401 → 522
    ArfGap_ASAP1; ArfGAP domain of ASAP1 (ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein 1)
    pfam03154
    Location:718 → 982
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:569 → 641
    Ank_2; Ankyrin repeats (3 copies)
    cl12013
    Location:12 → 217
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWY8.2 GenPept UniProtKB/Swiss-Prot:Q9QWY8

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