Dctn1 dynactin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dctn1provided by MGI
Official Full Name: dynactin 1provided by MGI
Primary source: MGI:MGI:107745
See related: Ensembl:ENSMUSG00000031865 AllianceGenome:MGI:107745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p150; Glued; DP-150; DAP-150; p150-glued; p150<glued>
Summary: Enables microtubule binding activity. Acts upstream of or within melanosome transport. Located in cell leading edge and microtubule cytoskeleton. Part of protein-containing complex. Is expressed in brain; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 36.9), frontal lobe adult (RPKM 32.3) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83142702..83177103)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83165909..83200118)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional assessment of the V390F mutation in the CCTdelta subunit of chaperonin containing tailless complex polypeptide 1.
Title: Functional assessment of the V390F mutation in the CCTδ subunit of chaperonin containing tailless complex polypeptide 1.
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
Title: Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150(glued).
The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway.
Title: The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway.
that a single mutation in the DCTN1 gene recapitulates symptoms of Perry syndrome patients
Title: Behavioral defects in a DCTN1(G71A) transgenic mouse model of Perry syndrome.
our findings demonstrate that p150(Glued) is particularly required to maintain the function and survival of spinal motor neurons during aging
Title: Genetic ablation of dynactin p150(Glued) in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.
p75NTR intracellular domain as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport
Title: Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150(Glued) Deacetylation by Axonal HDAC1.
a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.
Title: Low dietary protein content alleviates motor symptoms in mice with mutant dynactin/dynein-mediated neurodegeneration.
These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Title: Arl3 and LC8 regulate dissociation of dynactin from dynein.
Functional relationships between PIK3C3, dynactin, and AnkB promote axonal transport of organelles and are required for normal axon length.
Title: A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
The direct binding of the dynactin subunit p150(Glued) to JIP1 competitively inhibits KHC activation in vitro and disrupts the transport of APP in neurons.
Title: JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D6Umi3 (e-PCR), detects polymorphism
- UniSTS:142640

RH125419 (e-PCR)
- UniSTS:162241

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex region	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
part_of centriolar subdistal appendage	ISO Inferred from Sequence Orthology more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: dynactin subunit 1

Names: 150 kDa dynein-associated polypeptide; dynactin 1, retrograde axonal transport

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198866.2 → NP_001185795.1 dynactin subunit 1 isoform 2

See identical proteins and their annotated locations for NP_001185795.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC160400

Consensus CDS

CCDS57432.1

UniProtKB/TrEMBL

E9Q3M3, Q6NZM3

Related

ENSMUSP00000109546.2, ENSMUST00000113913.8

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:889 → 1030

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein
NM_001198867.2 → NP_001185796.1 dynactin subunit 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR,lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 3 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).

Source sequence(s)

AC160400

Consensus CDS

CCDS57433.1

UniProtKB/TrEMBL

E9Q586, Q3T9V8

Related

ENSMUSP00000076623.6, ENSMUST00000077407.12

Conserved Domains (3) summary

TIGR02168
Location:183 → 503

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:490 → 768

Dynactin; Dynein associated protein
NM_001347310.2 → NP_001334239.1 dynactin subunit 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks multiple exons in the coding region, and uses a novel start codon, compared to variant 1. Variant 4 encodes a protein (isoform 4) with a distinct and shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC160400

UniProtKB/TrEMBL

Q6NZM3
NM_001409578.1 → NP_001396507.1 dynactin subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC160400
NM_001409579.1 → NP_001396508.1 dynactin subunit 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC160400
NM_001409580.1 → NP_001396509.1 dynactin subunit 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC160400
NM_001409581.1 → NP_001396510.1 dynactin subunit 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC160400

UniProtKB/TrEMBL

D3YX34

Related

ENSMUSP00000109540.2, ENSMUST00000113907.2
NM_001409582.1 → NP_001396511.1 dynactin subunit 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC160400

UniProtKB/TrEMBL

E9Q586
NM_007835.3 → NP_031861.2 dynactin subunit 1 isoform 1

See identical proteins and their annotated locations for NP_031861.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC160400

Consensus CDS

CCDS39532.1

UniProtKB/Swiss-Prot

E9QLJ1, O08788, Q3TZG7

UniProtKB/TrEMBL

Q6NZM3

Related

ENSMUSP00000109552.4, ENSMUST00000113919.10

Conserved Domains (5) summary

pfam01302
Location:30 → 94

CAP_GLY; CAP-Gly domain

pfam08172
Location:314 → 455

CASP_C; CASP C terminal

pfam12455
Location:525 → 805

Dynactin; Dynein associated protein

pfam14915
Location:227 → 547

CCDC144C; CCDC144C protein coiled-coil region

cl23943
Location:246 → 342

PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83142702..83177103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505493.3 → XP_006505556.1 dynactin subunit 1 isoform X12

See identical proteins and their annotated locations for XP_006505556.1

UniProtKB/TrEMBL

Q3T9V8

Conserved Domains (3) summary

TIGR02168
Location:183 → 503

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:490 → 768

Dynactin; Dynein associated protein
XM_006505490.3 → XP_006505553.1 dynactin subunit 1 isoform X8

UniProtKB/TrEMBL

Q6NZM3

Conserved Domains (4) summary

TIGR02168
Location:197 → 517

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:64 → 204

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:504 → 782

Dynactin; Dynein associated protein
XM_006505492.3 → XP_006505555.1 dynactin subunit 1 isoform X10

UniProtKB/TrEMBL

Q6NZM3

Conserved Domains (4) summary

TIGR02168
Location:190 → 510

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:64 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:497 → 775

Dynactin; Dynein associated protein
XM_030255135.2 → XP_030110995.1 dynactin subunit 1 isoform X4

UniProtKB/TrEMBL

E9Q3M3, Q6NZM3

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:889 → 1030

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein
XM_006505494.2 → XP_006505557.1 dynactin subunit 1 isoform X12

See identical proteins and their annotated locations for XP_006505557.1

UniProtKB/TrEMBL

Q3T9V8

Conserved Domains (3) summary

TIGR02168
Location:183 → 503

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:490 → 768

Dynactin; Dynein associated protein
XM_036165800.1 → XP_036021693.1 dynactin subunit 1 isoform X4

UniProtKB/TrEMBL

E9Q3M3, Q6NZM3

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:889 → 1030

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein
XM_006505485.2 → XP_006505548.1 dynactin subunit 1 isoform X1

UniProtKB/TrEMBL

Q6NZM3

Related

ENSMUSP00000109551.2, ENSMUST00000113918.8

Conserved Domains (4) summary

TIGR02168
Location:220 → 540

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:101 → 214

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:527 → 805

Dynactin; Dynein associated protein
XM_006505486.4 → XP_006505549.1 dynactin subunit 1 isoform X2

UniProtKB/TrEMBL

Q6NZM3

Conserved Domains (4) summary

TIGR02168
Location:214 → 534

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:81 → 221

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:521 → 799

Dynactin; Dynein associated protein
XM_006505487.3 → XP_006505550.1 dynactin subunit 1 isoform X3

UniProtKB/TrEMBL

Q6NZM3

Conserved Domains (4) summary

TIGR02168
Location:207 → 527

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:81 → 214

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:514 → 792

Dynactin; Dynein associated protein
XM_017321379.2 → XP_017176868.1 dynactin subunit 1 isoform X5

UniProtKB/TrEMBL

Q3T9V8

Conserved Domains (4) summary

TIGR02168
Location:207 → 527

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:81 → 214

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:514 → 792

Dynactin; Dynein associated protein
XM_006505489.3 → XP_006505552.1 dynactin subunit 1 isoform X6

UniProtKB/TrEMBL

Q3T9V8

Conserved Domains (3) summary

TIGR02168
Location:200 → 520

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:507 → 785

Dynactin; Dynein associated protein
XM_006505491.4 → XP_006505554.1 dynactin subunit 1 isoform X9

UniProtKB/TrEMBL

Q3T9V8

Conserved Domains (3) summary

TIGR02168
Location:200 → 520

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:507 → 785

Dynactin; Dynein associated protein
XM_006505496.5 → XP_006505559.1 dynactin subunit 1 isoform X15

UniProtKB/TrEMBL

Q6NZM3

Conserved Domains (4) summary

TIGR02168
Location:220 → 540

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:101 → 214

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:527 → 805

Dynactin; Dynein associated protein
XM_006505488.3 → XP_006505551.1 dynactin subunit 1 isoform X4

See identical proteins and their annotated locations for XP_006505551.1

UniProtKB/TrEMBL

E9Q3M3, Q6NZM3

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:889 → 1030

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein