Dcc deleted in colorectal carcinoma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dccprovided by MGI
Official Full Name: deleted in colorectal carcinomaprovided by MGI
Primary source: MGI:MGI:94869
See related: Ensembl:ENSMUSG00000060534 AllianceGenome:MGI:94869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igdcc1; C030036D22Rik
Summary: Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is integral component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 7.6), CNS E14 (RPKM 7.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 45.24 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (71386703..72484299, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (71253613..72351228, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment.
Title: Prefrontal cortex-specific Dcc deletion induces schizophrenia-related behavioral phenotypes and fail to be rescued by olanzapine treatment.
DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.
Title: DCC/netrin-1 regulates cell death in oligodendrocytes after brain injury.
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype.
Title: Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype.
DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.
Title: DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.
Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons.
Title: Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons.
Revisiting the role of Dcc in visual system development with a novel eye clearing method.
Title: Revisiting the role of Dcc in visual system development with a novel eye clearing method.
Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus.
Title: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus.
This is the first study demonstrating the localization of DCC and Netrin-1 in the colonic myenteric plexus of the adult mice and their expression level determining two major neuronal subtypes regulating intestinal motility.
Title: Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon.
Knockdown of DCC or truncation of its P3 domain dramatically delays neuronal migration and impairs the multipolar-to-bipolar transition of migrating neurons.
Title: DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.
the identification of a large four-generational family that carries a mutation to the axon guidance molecule receptor gene, DCC, enabled us to demonstrate effects on mesocorticolimbic anatomical connectivity, striatal volumes, and personality traits
Title: Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers.

Submit: New GeneRIF Correction See all GeneRIFs (61)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Transgenic (1) 1 citation
Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237840

Dcc (e-PCR), detects polymorphism
- UniSTS:471087

Dcc (e-PCR), detects polymorphism
- UniSTS:471088

D18Mit141 (e-PCR), detects polymorphism
- UniSTS:116807

Dcc (e-PCR), detects polymorphism
- UniSTS:526935

NoName (e-PCR)
- UniSTS:548197

NoName (e-PCR)
- UniSTS:548198

D18Abb2e (e-PCR), detects polymorphism
- UniSTS:142184

NoName (e-PCR)
- UniSTS:548200

Dcc (e-PCR), detects polymorphism
- UniSTS:259448

Dcc (e-PCR), detects polymorphism
- UniSTS:531333

D1S3690 (e-PCR)
- UniSTS:474268

Dcc (e-PCR), detects polymorphism
- UniSTS:525216

GDB:201899 (e-PCR)
- UniSTS:156083

GDB:201912 (e-PCR)
- UniSTS:156096

D18Mit186 (e-PCR), detects polymorphism
- UniSTS:128205

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables netrin receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord ventral commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: netrin receptor DCC

Names: tumor suppressor protein DCC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007831.3 → NP_031857.2 netrin receptor DCC precursor

See identical proteins and their annotated locations for NP_031857.2

Status: VALIDATED

Source sequence(s)

AC136637, AK090377, AK157715, BQ550935, CN665025

Consensus CDS

CCDS29336.1

UniProtKB/Swiss-Prot

G3X9X6, P70211

Related

ENSMUSP00000110593.4, ENSMUST00000114943.11

Conserved Domains (8) summary

smart00408
Location:153 → 219

IGc2; Immunoglobulin C-2 Type

smart00060
Location:726 → 805

FN3; Fibronectin type 3 domain

cd00063
Location:528 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06583
Location:1148 → 1445

Neogenin_C; Neogenin C-terminus

pfam07679
Location:241 → 327

I-set; Immunoglobulin I-set domain

cd00096
Location:246 → 251

Ig; Ig strand A' [structural motif]

cd05722
Location:39 → 136

IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

cd05723
Location:334 → 417

IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

71386703..72484299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525588.5 → XP_006525651.1 netrin receptor DCC isoform X1

UniProtKB/Swiss-Prot

P70211

Related

ENSMUSP00000073094.6, ENSMUST00000073379.6

Conserved Domains (7) summary

cd05722
Location:42 → 136

Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins

smart00408
Location:153 → 219

IGc2; Immunoglobulin C-2 Type

smart00060
Location:726 → 805

FN3; Fibronectin type 3 domain

cd00063
Location:528 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06583
Location:1128 → 1425

Neogenin_C; Neogenin C-terminus

pfam07679
Location:241 → 327

I-set; Immunoglobulin I-set domain

cl11960
Location:347 → 417

Ig; Immunoglobulin domain