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LRRC15 leucine rich repeat containing 15 [ Homo sapiens (human) ]

Gene ID: 131578, updated on 17-Mar-2024

Summary

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Official Symbol
LRRC15provided by HGNC
Official Full Name
leucine rich repeat containing 15provided by HGNC
Primary source
HGNC:HGNC:20818
See related
Ensembl:ENSG00000172061 MIM:619327; AllianceGenome:HGNC:20818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIB
Summary
Enables collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues See more
Orthologs
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Genomic context

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See LRRC15 in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194355249..194369743, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197053410..197067898, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194075978..194090472, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21020 Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194033347-194033847 Neighboring gene Sharpr-MPRA regulatory region 2488 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:194039992-194041191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194057362-194058242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194059168-194059834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194071533-194072382 Neighboring gene carboxypeptidase N subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194089931-194090895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194120825-194121378 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194121379-194121931 Neighboring gene ATPase 13A3 Neighboring gene glycoprotein V platelet Neighboring gene MPRA-validated peak4979 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:194167532-194168731 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:194170227-194171426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21022 Neighboring gene ATP13A3 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Elusive Coreceptors for the SARS-CoV-2 Spike Protein. Berkowitz RL, et al. Viruses, 2022 Dec 25. PMID 36680105, Free PMC Article
  2. Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence. Gisby JS, et al. Nat Commun, 2022 Dec 15. PMID 36522333, Free PMC Article
  3. [Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus]. Li LZ, et al. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi, 2022 Jun 24. PMID 35896492
  4. Cancer‑associated fibroblast‑derived LRRC15 promotes the migration and invasion of triple‑negative breast cancer cells via Wnt/β‑catenin signalling pathway regulation. Yang Y, et al. Mol Med Rep, 2022 Jan. PMID 34726255, Free PMC Article
  5. Integrated microenvironment-associated genomic profiles identify LRRC15 mediating recurrent glioblastoma-associated macrophages infiltration. Tang H, et al. J Cell Mol Med, 2021 Jun. PMID 33960636, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-beta1-Induced PDL Fibroblastic Differentiation.
    Title: Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-β1-Induced PDL Fibroblastic Differentiation.
  2. RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.
    Title: RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15.
  3. Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.
    Title: Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.
  4. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
    Title: Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
  5. LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
    Title: LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein.
  6. The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
    Title: The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.
  7. LRRC15 inhibits SARS-CoV-2 cellular entry in trans.
    Title: LRRC15 inhibits SARS-CoV-2 cellular entry in trans.
  8. [Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus].
    Title: [Eukaryotic expression and antigen epitope prediction of the LRRC15 protein in excretory secretory antigens of Taenia solium cysticercus].
  9. Cancerassociated fibroblastderived LRRC15 promotes the migration and invasion of triplenegative breast cancer cells via Wnt/betacatenin signalling pathway regulation.
    Title: Cancer‑associated fibroblast‑derived LRRC15 promotes the migration and invasion of triple‑negative breast cancer cells via Wnt/β‑catenin signalling pathway regulation.
  10. Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
    Title: Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables collagen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables laminin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated virion attachment to host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor-mediated virion attachment to host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 15
Names
hLib
leucine-rich repeat protein induced by beta amyloid
leucine-rich repeat protein induced by beta-amyloid homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135057.3 → NP_001128529.2  leucine-rich repeat-containing protein 15 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC174158, BC101064, BK001325
    Consensus CDS
    CCDS46984.1
    UniProtKB/TrEMBL
    B3KWI4
    Related
    ENSP00000413707.1, ENST00000428839.1
    Conserved Domains (5) summary
    cd00116
    Location:63 → 309
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:109 → 156
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:299 → 340
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:180 → 239
    LRR_8; Leucine rich repeat
    cl15307
    Location:429 → 468
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. NM_130830.5 → NP_570843.2  leucine-rich repeat-containing protein 15 isoform b precursor

    See identical proteins and their annotated locations for NP_570843.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC174158, AK125112
    Consensus CDS
    CCDS3306.1
    UniProtKB/Swiss-Prot
    Q495Q6, Q7RTN7, Q8TF66
    UniProtKB/TrEMBL
    B3KWI4
    Related
    ENSP00000306276.4, ENST00000347624.4
    Conserved Domains (4) summary
    TIGR00864
    Location:396 → 467
    PCC; polycystin cation channel protein
    COG4886
    Location:220 → 405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:103 → 150
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:149 → 209
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    194355249..194369743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    197053410..197067898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TF66.2 GenPept UniProtKB/Swiss-Prot:Q8TF66

Gene LinkOut

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