U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CRYBG3 crystallin beta-gamma domain containing 3 [ Homo sapiens (human) ]

Gene ID: 131544, updated on 10-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CRYBG3provided by HGNC
Official Full Name
crystallin beta-gamma domain containing 3provided by HGNC
Primary source
HGNC:HGNC:34427
See related
Ensembl:ENSG00000080200 MIM:620146; AllianceGenome:HGNC:34427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
vlAKAP; DKFZp667G2110
Summary
Enables protein kinase A binding activity. Predicted to be involved in lens development in camera-type eye and visual perception. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 19.9), testis (RPKM 9.8) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q11.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (97822011..97944984)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (100525753..100648725)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (97540855..97663828)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene EPH receptor A6 Neighboring gene uncharacterized LOC124906256 Neighboring gene NANOG hESC enhancer GRCh37_chr3:97466009-97466510 Neighboring gene H3K27ac hESC enhancers GRCh37_chr3:97482933-97483434 and GRCh37_chr3:97483435-97483934 Neighboring gene uncharacterized LOC101929298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14552 Neighboring gene uncharacterized LOC105373994 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:97614773-97615564 Neighboring gene ADP ribosylation factor like GTPase 6 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:97628706-97629296 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:97629297-97629886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14553 Neighboring gene uncharacterized LOC124909398 Neighboring gene Sharpr-MPRA regulatory region 5379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20130 Neighboring gene ribosomal oxygenase 2 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction. Zheng L, et al. Cell Death Dis, 2022 Mar 4. PMID 35246511, Free PMC Article
  2. Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis. Wu A, et al. Int J Mol Sci, 2021 Mar 22. PMID 33809929, Free PMC Article
  3. The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3. Guo Z, et al. Oncogene, 2021 Mar. PMID 33564066, Free PMC Article
  4. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. Burgers PP, et al. Biochemistry, 2015 Jan 13. PMID 25097019
  5. Same but different - Molecular comparison of human KTI12 and PSTK. Smejda M, et al. Biochim Biophys Acta Mol Cell Res, 2021 Apr. PMID 33417976

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction.
    Title: Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction.
  2. Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis.
    Title: Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ60082, DKFZp686L13211

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
very large A-kinase anchor protein
Names
beta-gamma crystallin domain containing 3
beta/gamma crystallin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153605.4 → NP_705833.3  very large A-kinase anchor protein

    See identical proteins and their annotated locations for NP_705833.3

    Status: VALIDATED

    Source sequence(s)
    AC110491, AF451988, AK091199, AK296966, BM974654
    Consensus CDS
    CCDS43113.2
    UniProtKB/Swiss-Prot
    B4DLE8, F6VHI2, Q4G0V8, Q68DQ2, Q7Z4R9, Q86VD0, Q8N262, Q8N7F1, Q8NDQ8
    Related
    ENSP00000374273.3, ENST00000389622.7
    Conserved Domains (4) summary
    cd00161
    Location:2838 → 2967
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00030
    Location:2574 → 2655
    Crystall; Beta/Gamma crystallin
    pfam00652
    Location:2839 → 2965
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl02528
    Location:2406 → 2448
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    97822011..97944984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247117.5 → XP_005247174.1  very large A-kinase anchor protein isoform X1

    Conserved Domains (4) summary
    cd00161
    Location:2547 → 2676
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00030
    Location:2283 → 2364
    Crystall; Beta/Gamma crystallin
    pfam00652
    Location:2548 → 2674
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl02528
    Location:2115 → 2157
    Crystall; Beta/Gamma crystallin

  2. XM_047447439.1 → XP_047303395.1  very large A-kinase anchor protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    100525753..100648725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345223.1 → XP_054201198.1  very large A-kinase anchor protein isoform X1

  2. XM_054345224.1 → XP_054201199.1  very large A-kinase anchor protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68DQ2.3 GenPept UniProtKB/Swiss-Prot:Q68DQ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous