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Dapk2 death-associated protein kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 13143, updated on 11-Apr-2024

Summary

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Official Symbol
Dapk2provided by MGI
Official Full Name
death-associated protein kinase 2provided by MGI
Primary source
MGI:MGI:1341297
See related
Ensembl:ENSMUSG00000032380 AllianceGenome:MGI:1341297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Involved in neutrophil migration. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Is expressed in clavicle; diencephalon lateral wall ventricular layer; mandible; maxilla; and orbito-sphenoid. Orthologous to human DAPK2 (death associated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 10.8), placenta adult (RPKM 9.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 35.75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66065364..66179524)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66158226..66272242)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24475 Neighboring gene sorting nexin 1 Neighboring gene STARR-positive B cell enhancer ABC_E5080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene STARR-positive B cell enhancer mm9_chr9:66059936-66060237 Neighboring gene STARR-seq mESC enhancer starr_24478 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66128344-66128644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66129452-66129653 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 39364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Death associated protein kinase 2 is expressed in cortical interstitial cells of the mouse kidney. Guay JA, et al. BMC Res Notes, 2014 Jun 7. PMID 24906443, Free PMC Article
  2. Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase. Patel AK, et al. J Mol Biol, 2011 Jun 10. PMID 21497605
  3. cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2. Isshiki K, et al. Biochem Biophys Res Commun, 2012 Jun 1. PMID 22580283
  4. Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2. Fang J, et al. Blood, 2008 Aug 1. PMID 18535204, Free PMC Article
  5. Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissue. Shimoda M, et al. J Exp Med, 2001 Dec 3. PMID 11733574, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
    Title: Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
  2. This study links adipocyte expression of an autophagy-regulating kinase, lysosome-mediated clearance and fat cell lipid accumulation; it demonstrates obesity-related attenuated autophagy in adipocytes, and identifies DAPK2 dependence in this regulation.
    Title: DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity.
  3. DAPK2 is strongly and specifically expressed in interstitial cells of the cortex, providing a useful marker for this important cell population
    Title: Death associated protein kinase 2 is expressed in cortical interstitial cells of the mouse kidney.
  4. The defect in chemotaxis in DAPK2-inactive granulocytes is likely a result of reduced polarization of the cells, mediated by a lack of MLC phosphorylation, resulting in radial F-actin and pseudopod formation.
    Title: DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants.
  5. These results suggest that DAPK2 is one of the targets of cGK-I in apoptosis induction.
    Title: cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2.
  6. The crystal and solution structures of murine DAPK2 were determined in the presence of the autoinhibitory domain, with and without bound nucleotides in the active site. Dimers of DAPK2 had a conformation that did not permit protein substrate binding.
    Title: Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase.
  7. DAPK2 was substantially up-modulated during late erythropoiesis
    Title: Attenuation of EPO-dependent erythroblast formation by death-associated protein kinase-2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anoikis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in neutrophil migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
death-associated protein kinase 2
Names
DAP kinase 2
DRP-1
death-associated kinase 2
NP_001391612.1
NP_034149.2
XP_036010490.1
XP_036010491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404683.1 → NP_001391612.1  death-associated protein kinase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124439
    UniProtKB/TrEMBL
    E9JGN0
    Related
    ENSMUSP00000158747.2, ENSMUST00000238682.2

  2. NM_010019.4 → NP_034149.2  death-associated protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_034149.2

    Status: VALIDATED

    Source sequence(s)
    AC124439
    Consensus CDS
    CCDS23303.1
    UniProtKB/Swiss-Prot
    O88861, Q8VDF3, Q9QYM4
    Related
    ENSMUSP00000034944.3, ENSMUST00000034944.9
    Conserved Domains (1) summary
    cd14196
    Location:17 → 285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66065364..66179524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154597.1 → XP_036010490.1  death-associated protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036154598.1 → XP_036010491.1  death-associated protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 130
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004935315.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDF3.1 GenPept UniProtKB/Swiss-Prot:Q8VDF3

Gene LinkOut

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