U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dgka diacylglycerol kinase, alpha [ Mus musculus (house mouse) ]

Gene ID: 13139, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Dgkaprovided by MGI
Official Full Name
diacylglycerol kinase, alphaprovided by MGI
Primary source
MGI:MGI:102952
See related
Ensembl:ENSMUSG00000025357 AllianceGenome:MGI:102952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
80kDa; Dagk1
Summary
Enables diacylglycerol kinase activity and phospholipid binding activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and lipid phosphorylation. Predicted to act upstream of or within lipid metabolic process and phosphorylation. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; integumental system; respiratory system; and sensory organ. Orthologous to human DGKA (diacylglycerol kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 101.8), spleen adult (RPKM 51.2) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dgka in Genome Data Viewer
Location:
10 D3; 10 77.14 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128556000..128581002, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128720131..128745084, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E50 Neighboring gene STARR-positive B cell enhancer ABC_E2974 Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5201 Neighboring gene STARR-seq mESC enhancer starr_28299 Neighboring gene STARR-positive B cell enhancer ABC_E10661 Neighboring gene STARR-seq mESC enhancer starr_28300 Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene ribosomal protein SA, pseudogene 2 Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice. Kudek MR, et al. J Immunol, 2023 May 1. PMID 36920384,
  2. Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness. Manigat LC, et al. Front Immunol, 2021. PMID 34804012, Free PMC Article
  3. Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet. Nascimento EBM, et al. J Lipid Res, 2018 Feb. PMID 29233919, Free PMC Article
  4. Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. Hayashi D, et al. Sci Rep, 2017 Jun 1. PMID 28572624, Free PMC Article
  5. Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. Chauveau A, et al. Sci Signal, 2014 Aug 26. PMID 25161317, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of DGKalpha facilitates alpha-smooth muscle actin expression via the Smad and PKCdelta signaling pathways during the acute phase of CCl4 -induced hepatic injury.
    Title: Ablation of DGKα facilitates α-smooth muscle actin expression via the Smad and PKCδ signaling pathways during the acute phase of CCl(4) -induced hepatic injury.
  2. Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase alpha-Deficient Mice.
    Title: Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice.
  3. Loss of Diacylglycerol Kinase alpha Enhances Macrophage Responsiveness.
    Title: Loss of Diacylglycerol Kinase α Enhances Macrophage Responsiveness.
  4. DGK alpha and zeta Activities Control TH1 and TH17 Cell Differentiation.
    Title: DGK α and ζ Activities Control T(H)1 and T(H)17 Cell Differentiation.
  5. results suggest DGKalpha aids in modulating the early immune response of adipose tissue following an acute exposure to high-fat diet, possibly through modulation of acute T-cell action
    Title: Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.
  6. this study shows that diacylglycerol kinase alpha is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice
    Title: Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice.
  7. Diacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review)
    Title: Diacylglycerol kinases in cancer.
  8. Our studies demonstrate that PKD1/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.
    Title: Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.
  9. Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
    Title: Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
  10. It plays a role in pathogenesis of various disorders in the central nervous system.
    Title: The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables alkylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
diacylglycerol kinase alpha
Names
80 kDa diacylglycerol kinase
DAG kinase alpha
DGK-alpha
diacylglycerol kinase alpha Flt2-Pr2
diglyceride kinase alpha
NP_001345674.1
NP_001345675.1
NP_001359295.1
NP_001360957.1
NP_058091.2
XP_011241653.2
XP_011241661.1
XP_011241665.2
XP_017169275.2
XP_017169279.2
XP_030100725.1
XP_036011466.1
XP_036011467.1
XP_036011468.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358745.2 → NP_001345674.1  diacylglycerol kinase alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131081
    Consensus CDS
    CCDS24290.1
    UniProtKB/Swiss-Prot
    O88673, Q922X2
    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:515 → 696
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:374 → 494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:115 → 184
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:207 → 255
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 111
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. NM_001358746.2 → NP_001345675.1  diacylglycerol kinase alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131081
    Consensus CDS
    CCDS24290.1
    UniProtKB/Swiss-Prot
    O88673, Q922X2
    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:515 → 696
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:374 → 494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:115 → 184
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:207 → 255
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 111
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. NM_001372366.1 → NP_001359295.1  diacylglycerol kinase alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131081
    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (6) summary
    smart00045
    Location:550 → 731
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:409 → 529
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:150 → 219
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 146
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:306 → 367
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:237 → 297
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  4. NM_001374028.2 → NP_001360957.1  diacylglycerol kinase alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131081
    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:538 → 719
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:397 → 517
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:138 → 207
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:230 → 278
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 134
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. NM_001428430.1 → NP_001415359.1  diacylglycerol kinase alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131081

  6. NM_001428431.1 → NP_001415360.1  diacylglycerol kinase alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131081

  7. NM_001428432.1 → NP_001415361.1  diacylglycerol kinase alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131081

  8. NM_016811.4 → NP_058091.2  diacylglycerol kinase alpha isoform 1

    See identical proteins and their annotated locations for NP_058091.2

    Status: VALIDATED

    Source sequence(s)
    AC131081
    Consensus CDS
    CCDS24290.1
    UniProtKB/Swiss-Prot
    O88673, Q922X2
    UniProtKB/TrEMBL
    R4I4W1
    Related
    ENSMUSP00000026414.8, ENSMUST00000026414.9
    Conserved Domains (5) summary
    smart00045
    Location:515 → 696
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:374 → 494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:115 → 184
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:207 → 255
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 111
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RNA

  1. NR_190347.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131081

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128556000..128581002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155574.1 → XP_036011467.1  diacylglycerol kinase alpha isoform X6

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:373 → 554
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:232 → 352
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:1 → 42
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20890
    Location:129 → 190
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:60 → 120
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_036155575.1 → XP_036011468.1  diacylglycerol kinase alpha isoform X6

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:373 → 554
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:232 → 352
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:1 → 42
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd20890
    Location:129 → 190
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:60 → 120
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  3. XM_030244865.2 → XP_030100725.1  diacylglycerol kinase alpha isoform X5

    UniProtKB/Swiss-Prot
    O88673, Q922X2
    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:515 → 696
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:374 → 494
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:115 → 184
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:207 → 255
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 111
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. XM_011243359.3 → XP_011241661.1  diacylglycerol kinase alpha isoform X4

    See identical proteins and their annotated locations for XP_011241661.1

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (5) summary
    smart00045
    Location:538 → 719
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:397 → 517
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:138 → 207
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:230 → 278
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:4 → 134
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. XM_011243351.3 → XP_011241653.2  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (6) summary
    smart00045
    Location:550 → 731
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:409 → 529
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:150 → 219
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 146
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:306 → 367
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:237 → 297
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  6. XM_017313786.3 → XP_017169275.2  diacylglycerol kinase alpha isoform X2

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (6) summary
    smart00045
    Location:550 → 731
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:409 → 529
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:150 → 219
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 146
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:306 → 367
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:237 → 297
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  7. XM_036155573.1 → XP_036011466.1  diacylglycerol kinase alpha isoform X1

    UniProtKB/TrEMBL
    R4I4W1
    Conserved Domains (6) summary
    smart00045
    Location:573 → 754
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:432 → 552
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:173 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 169
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:329 → 390
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:260 → 320
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  8. XM_017313790.2 → XP_017169279.2  diacylglycerol kinase alpha isoform X8

    UniProtKB/TrEMBL
    R4I3X7
    Conserved Domains (4) summary
    cd00051
    Location:150 → 219
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 146
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:306 → 367
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:237 → 297
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  9. XM_011243363.2 → XP_011241665.2  diacylglycerol kinase alpha isoform X7

    UniProtKB/TrEMBL
    R4I3X7
    Conserved Domains (4) summary
    cd00051
    Location:173 → 242
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:39 → 169
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:329 → 390
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:260 → 320
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

RNA

  1. XR_003948587.2 RNA Sequence

    Related
    ENSMUST00000219834.2

  2. XR_001779451.2 RNA Sequence

  3. XR_380362.4 RNA Sequence

  4. XR_001779449.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88673.2 GenPept UniProtKB/Swiss-Prot:O88673

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous