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Cd55b CD55 molecule, decay accelerating factor for complement B [ Mus musculus (house mouse) ]

Gene ID: 13137, updated on 3-Apr-2024

Summary

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Official Symbol
Cd55bprovided by MGI
Official Full Name
CD55 molecule, decay accelerating factor for complement Bprovided by MGI
Primary source
MGI:MGI:104849
See related
Ensembl:ENSMUSG00000026401 AllianceGenome:MGI:104849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Daf; Daf2; Daf-TM; TM-DAF
Summary
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. This gene is located adjacent to a closely related gene on chromosome 1 and preferentially expressed in the spleen and testis. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis adult (RPKM 55.5), spleen adult (RPKM 8.2) and 8 other tissues See more
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Genomic context

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See Cd55b in Genome Data Viewer
Location:
1 E4; 1 56.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130316263..130350831, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130388526..130423097, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_02191 Neighboring gene STARR-seq mESC enhancer starr_02192 Neighboring gene predicted gene 29428 Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene predicted gene, 41951 Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene CD55 molecule, decay accelerating factor for complement Neighboring gene predicted gene 16083 Neighboring gene zona pellucida 3 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular and functional analysis of mouse decay accelerating factor (CD55). Harris CL, et al. Biochem J, 1999 Aug 1. PMID 10417349, Free PMC Article
  2. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Sun X, et al. Proc Natl Acad Sci U S A, 1999 Jan 19. PMID 9892684, Free PMC Article
  3. A new repetitive sequence uniquely present in the decay-accelerating factor genes. Nonaka M, et al. Immunogenetics, 1998. PMID 9435343
  4. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. Spicer AP, et al. J Immunol, 1995 Sep 15. PMID 7545711
  5. Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis. Aly M, et al. Genes Immun, 2007 Apr. PMID 17287827

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156369

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement decay-accelerating factor transmembrane isoform
Names
complement-transmembrane
decay accelerating factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317361.1 → NP_001304290.1  complement decay-accelerating factor transmembrane isoform isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC111067, CJ046619, CJ236680, L41365
    Consensus CDS
    CCDS83587.1
    UniProtKB/TrEMBL
    A0JP41, E9Q731
    Related
    ENSMUSP00000113352.2, ENSMUST00000119432.2
    Conserved Domains (3) summary
    cd00033
    Location:34 → 93
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:161 → 218
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:96 → 156
    Sushi; Sushi repeat (SCR repeat)

  2. NM_001404948.1 → NP_001391877.1  complement decay-accelerating factor transmembrane isoform isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC111067, AC116692

  3. NM_007827.3 → NP_031853.2  complement decay-accelerating factor transmembrane isoform isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC111067, CJ046619, CJ236680, L41365
    Consensus CDS
    CCDS35699.1
    UniProtKB/Swiss-Prot
    E9QLT3, Q61476
    UniProtKB/TrEMBL
    E9QAP4
    Related
    ENSMUSP00000108107.3, ENSMUST00000112488.9
    Conserved Domains (3) summary
    cd00033
    Location:223 → 283
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:161 → 218
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00084
    Location:96 → 156
    Sushi; Sushi repeat (SCR repeat)

RNA

  1. NR_175893.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067, AC116692

  2. NR_175894.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067, AC116692

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130316263..130350831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314396.3 → XP_017169885.1  complement decay-accelerating factor transmembrane isoform isoform X4

    UniProtKB/Swiss-Prot
    E9QLT3, Q61476
    Conserved Domains (2) summary
    cd00033
    Location:52 → 111
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:110 → 297
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61476.2 GenPept UniProtKB/Swiss-Prot:Q61476

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