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Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]

Gene ID: 13136, updated on 18-Apr-2024

Summary

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Official Symbol
Cd55provided by MGI
Official Full Name
CD55 molecule, decay accelerating factor for complementprovided by MGI
Primary source
MGI:MGI:104850
See related
Ensembl:ENSMUSG00000026399 AllianceGenome:MGI:104850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Daf; Daf1; Daf-GPI; GPI-DAF
Summary
This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
Expression
Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130357526..130390513, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130429798..130465009, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02193 Neighboring gene predicted gene, 41951 Neighboring gene STARR-seq mESC enhancer starr_02194 Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene zona pellucida 3 receptor Neighboring gene predicted gene, 23623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD55 Is Essential for CD103(+) Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity. Strainic MG, et al. Am J Pathol, 2019 Jul. PMID 31103439, Free PMC Article
  2. Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone. Zhang Y, et al. Clin Exp Immunol, 2019 Sep. PMID 31091357, Free PMC Article
  3. CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors. Saygin C, et al. J Exp Med, 2017 Sep 4. PMID 28838952, Free PMC Article
  4. Late stage definitive endodermal differentiation can be defined by Daf1 expression. Ogaki S, et al. BMC Dev Biol, 2016 May 31. PMID 27245320, Free PMC Article
  5. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Karpus ON, et al. Arthritis Res Ther, 2015 Jan 17. PMID 25596646, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Critical Role of CD55 in Controlling Wound Healing.
    Title: Critical Role of CD55 in Controlling Wound Healing.
  2. Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
    Title: Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.
  3. Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
    Title: Mitigating placental injuries through up-regulating DAF in experimental APS mice: new mechanism of progesterone.
  4. DAF is required for the properties of CD103(+) DCs and their naive CD4(+) cell partners that together program tolerance.
    Title: CD55 Is Essential for CD103(+) Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
  5. CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.
    Title: Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
  6. regulates self-renewal and cisplatin resistance in endometrioid tumors
    Title: CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
  7. Results show that definitive endoderm (DE) expressing Daf1 are slowly proliferating and adhesive cells suggesting that Daf1 is a marker of late stage DE.
    Title: Late stage definitive endodermal differentiation can be defined by Daf1 expression.
  8. these data show a key role for HIF-1alpha in regulating the expression of CD55 on airway epithelium.
    Title: Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium.
  9. CD55 is produced by the synovium and deposited on local collagen fiber meshwork, where it protects against immune complex-mediated arthritis.
    Title: CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.
  10. Fibrosis in Daf1-/- mice was accompanied by high expression of alpha-smooth muscle actin.
    Title: Decay-accelerating factor 1 deficiency exacerbates leptospiral-induced murine chronic nephritis and renal fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • AC111067.4

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of complement activation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of complement activation, classical pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement decay-accelerating factor, GPI-anchored
Names
CD55 antigen
Cromer blood group
GPI anchor addition signal
complement-glycosylphosphatidylinositol
decay accelerating factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404959.1 → NP_001391888.1  complement decay-accelerating factor, GPI-anchored isoform 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067

  2. NM_001404960.2 → NP_001391889.1  complement decay-accelerating factor, GPI-anchored isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067

  3. NM_001420093.1 → NP_001407022.1  complement decay-accelerating factor, GPI-anchored isoform 4 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC111067

  4. NM_010016.5 → NP_034146.2  complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034146.2

    Status: REVIEWED

    Source sequence(s)
    AC111067
    Consensus CDS
    CCDS15256.1
    UniProtKB/Swiss-Prot
    P97732, Q3TU32, Q4FJS4, Q61397, Q61475, Q76N72, Q921P0, Q9R1C1
    Related
    ENSMUSP00000027650.7, ENSMUST00000027650.13
    Conserved Domains (2) summary
    cd00033
    Location:225 → 285
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:98 → 158
    Sushi; Sushi repeat (SCR repeat)

RNA

  1. NR_175895.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067

  2. NR_175896.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC111067

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130357526..130390513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246237.2 → XP_030102097.1  complement decay-accelerating factor, GPI-anchored isoform X2

    Conserved Domains (3) summary
    pfam00802
    Location:285 → 361
    Glycoprotein_G; Pneumovirus attachment glycoprotein G
    cd00033
    Location:36 → 95
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:98 → 292
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61475.2 GenPept UniProtKB/Swiss-Prot:Q61475

Gene LinkOut

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