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AHSA2P activator of HSP90 ATPase homolog 2, pseudogene [ Homo sapiens (human) ]

Gene ID: 130872, updated on 5-Mar-2024

Summary

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Official Symbol
AHSA2Pprovided by HGNC
Official Full Name
activator of HSP90 ATPase homolog 2, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:20437
See related
Ensembl:ENSG00000293434 AllianceGenome:HGNC:20437
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHA1; Hch1; AHSA2
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in positive regulation of ATPase activity and protein folding. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 24.2), lymph node (RPKM 21.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
2p15
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (61177418..61188925)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (61183270..61194773)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (61404553..61416060)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:61371323-61372244 Neighboring gene C2orf74 divergent transcript Neighboring gene C2orf74 antisense RNA 1 Neighboring gene chromosome 2 open reading frame 74 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:61395441-61395942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:61407627-61408205 Neighboring gene ubiquitin specific peptidase 34 Neighboring gene Sharpr-MPRA regulatory region 13579 Neighboring gene BNIP3 pseudogene 45 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:61504619-61505818 Neighboring gene NANOG hESC enhancer GRCh37_chr2:61607882-61608383 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:61644005-61644197 Neighboring gene small nucleolar RNA, H/ACA box 70B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers. Han SW, et al. Sci Rep, 2020 Apr 28. PMID 32345988, Free PMC Article
  2. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. Meyer P, et al. EMBO J, 2004 Feb 11. PMID 14739935, Free PMC Article
  3. Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites. Ficarro SB, et al. Rapid Commun Mass Spectrom, 2005. PMID 15570572
  4. Multiple common variants for celiac disease influencing immune gene expression. Dubois PC, et al. Nat Genet, 2010 Apr. PMID 20190752, Free PMC Article
  5. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Chen Z, et al. Mol Cell Proteomics, 2020 Mar. PMID 31900314, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers.
    Title: Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • AHA1, activator of heat shock 90kDa protein ATPase homolog 2
  • activator of 90 kDa heat shock protein ATPase homolog 2

Clone Names

  • FLJ34679, FLJ41715, DKFZp564C236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_152210.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016747, BC050395

  2. NR_152211.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA856729, AC016747, BC030998
    Related
    ENST00000357022.6

  3. NR_152212.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA856729, AC016747

  4. NR_152213.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA856729, AC016747
    Related
    ENST00000642732.1

  5. NR_152215.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA856729, AC016747, BC063789

  6. NR_152216.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA856729, AC016747, AK092505, BC063789

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    61177418..61188925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    61183270..61194773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001321300.1: Suppressed sequence

    Description
    NM_001321300.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  2. NM_001321301.1: Suppressed sequence

    Description
    NM_001321301.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  3. NM_001321302.1: Suppressed sequence

    Description
    NM_001321302.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  4. NM_001321303.1: Suppressed sequence

    Description
    NM_001321303.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  5. NM_001321304.1: Suppressed sequence

    Description
    NM_001321304.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  6. NM_001321305.1: Suppressed sequence

    Description
    NM_001321305.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  7. NM_152392.4: Suppressed sequence

    Description
    NM_152392.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q719I0.2 GenPept UniProtKB/Swiss-Prot:Q719I0

Gene LinkOut

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