Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp1a1provided by MGI
Official Full Name: cytochrome P450, family 1, subfamily a, polypeptide 1provided by MGI
Primary source: MGI:MGI:88588
See related: Ensembl:ENSMUSG00000032315 AllianceGenome:MGI:88588
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AHH; AHRR; CP11; CYPIA1; P450-1
Summary: Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; response to toxic substance; and toxin metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; maxillary process; spleen; and upper jaw. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 18.0), lung adult (RPKM 13.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57595211..57611107)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57687928..57703824)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life.
Title: Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Title: Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis.
Title: Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis.
Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells.
Title: Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells.
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-kappaB activation.
Title: Knockout of cytochrome P450 1A1 enhances lipopolysaccharide-induced acute lung injury in mice by targeting NF-κB activation.
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Title: CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway.
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Title: Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients.
Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.
Title: Pinocembrin attenuates benzo(a)pyrene-induced CYP1A1 expression through multiple pathways: An in vitro and in vivo study.
Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
Title: Cytochrome P450 1A1 enhances Arginase-1 expression, which reduces LPS-induced mouse peritonitis by targeting JAK1/STAT6.
These results suggest that intracellular accumulation of serotonin (5-HT) via SERT induces CYP1A1 expression via AhR in intestinal epithelial cells, and SERT deficiency in vivo impairs activation of AhR.
Title: Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

D9Mit28 (e-PCR), detects polymorphism
- UniSTS:131847

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:261904

PMC133867P1 (e-PCR)
- UniSTS:270672

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:461912

PMC300765P1 (e-PCR)
- UniSTS:272473

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:462979

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:141446

PMC15407P1 (e-PCR)
- UniSTS:271291

M10021 (e-PCR)
- UniSTS:124914

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	ISO Inferred from Sequence Orthology more info
enables demethylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables flavonoid 3'-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
contributes_to oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on diphenols and related substances as donors	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables vitamin D 24-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
involved_in coumarin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dibenzo-p-dioxin catabolic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within dibenzo-p-dioxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in flavonoid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heterocycle metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insecticide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in porphyrin-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within toxin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 1A1

Names: cytochrome P450 form 6; cytochrome P450 subfamily I, polypeptide 1; cytochrome P450, 1a1, aromatic compound inducible; cytochrome P450-C; cytochrome P450-P1; hydroperoxy icosatetraenoate dehydratase

NP_001129531.1

EC 1.14.14.1

EC 4.2.1.152

NP_034122.1

EC 1.14.14.1

EC 4.2.1.152

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136059.2 → NP_001129531.1 cytochrome P450 1A1

See identical proteins and their annotated locations for NP_001129531.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AW110759, Y00071

Consensus CDS

CCDS23230.1

UniProtKB/Swiss-Prot

P00184, Q61455

UniProtKB/TrEMBL

Q05A20

Related

ENSMUSP00000034865.5, ENSMUST00000034865.6

Conserved Domains (1) summary

pfam00067
Location:44 → 503

p450; Cytochrome P450
NM_009992.4 → NP_034122.1 cytochrome P450 1A1

See identical proteins and their annotated locations for NP_034122.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK005000, AW110759

Consensus CDS

CCDS23230.1

UniProtKB/Swiss-Prot

P00184, Q61455

UniProtKB/TrEMBL

Q05A20

Related

ENSMUSP00000150277.2, ENSMUST00000216433.2

Conserved Domains (1) summary

pfam00067
Location:44 → 503

p450; Cytochrome P450