Cyct cytochrome c, testis [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyctprovided by MGI
Official Full Name: cytochrome c, testisprovided by MGI
Primary source: MGI:MGI:88579
See related: Ensembl:ENSMUSG00000056436 AllianceGenome:MGI:88579
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T-Cc
Summary: Enables heme binding activity. Acts upstream of or within hydrogen peroxide metabolic process and positive regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. Orthologous to human CYCTP (cytochrome c, testis, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 15.3) See more
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Genomic context

Location:: 2 C3; 2 44.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (76184286..76190797, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (76353942..76360453, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that heat stress of testes triggers the release of cytochrome c from mitochondria in spermatogenic cells, leading to the activation of an apoptotic pathway.
Title: Suppression of cytochrome c release and apoptosis in testes with heat stress by minocycline.
T-Cc can catalyze reduction of H(2)O(2) 3 times faster than somatic cell Cc(S-Cc); T-Cc heme has greater resistance to degradation by H(2)O(2); implies T-Cc can protect sperm from H(2)O(2)damage; T-Cc apoptotic activity is 3 to 5 times greater than S-Cc
Title: Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hydrogen peroxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c, testis-specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009989.3 → NP_034119.1 cytochrome c, testis-specific

See identical proteins and their annotated locations for NP_034119.1

Status: VALIDATED

Source sequence(s)

AL845373, BC049608

Consensus CDS

CCDS16156.1

UniProtKB/Swiss-Prot

P00015

UniProtKB/TrEMBL

Q6PBG3

Related

ENSMUSP00000028430.5, ENSMUST00000028430.6

Conserved Domains (1) summary

COG3474
Location:1 → 105

Cyc7; Cytochrome c2 [Energy production and conversion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

76184286..76190797 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239273.1 → XP_011237575.1 cytochrome c, testis-specific isoform X1

See identical proteins and their annotated locations for XP_011237575.1

UniProtKB/Swiss-Prot

P00015

UniProtKB/TrEMBL

Q6PBG3

Conserved Domains (1) summary

COG3474
Location:1 → 105

Cyc7; Cytochrome c2 [Energy production and conversion]