U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cyb561 cytochrome b-561 [ Mus musculus (house mouse) ]

Gene ID: 13056, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cyb561provided by MGI
Official Full Name
cytochrome b-561provided by MGI
Primary source
MGI:MGI:103253
See related
Ensembl:ENSMUSG00000019590 AllianceGenome:MGI:103253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis and cellular iron ion homeostasis. Located in chromaffin granule membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; node; and nose. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 144.4), adrenal adult (RPKM 27.6) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 E1; 11 68.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105824528..105844157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105933702..105945019, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors. Srivastava A, et al. Cancer Biomark, 2010. PMID 21045261
  2. Heterologous expression and site-directed mutagenesis of an ascorbate-reducible cytochrome b561. Bérczi A, et al. Arch Biochem Biophys, 2005 Nov 15. PMID 16256064
  3. Mouse cytochrome b561: cDNA cloning and expression in rat brain, mouse embryos, and human glioma cell lines. Srivastava M, et al. DNA Cell Biol, 1998 Sep. PMID 9778036
  4. Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome. van den Berg MP, et al. Circ Res, 2018 Mar 16. PMID 29343526, Free PMC Article
  5. Dihydrolipoic acid reduces cytochrome b561 proteins. Bérczi A, et al. Eur Biophys J, 2013 Mar. PMID 22526465

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dihydrolipoic acid (DHLA)-dependent reduction of these two Cyt-b561 proteins
    Title: Dihydrolipoic acid reduces cytochrome b561 proteins.
  2. expression of Cytochrome b561, is androgen regulated in the context of CaP cells and its increased expression in castration recurrent prostate cancer reflects increased androgen receptor signaling in tumor cells
    Title: Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors.
  3. Data show that four members of the b561 family of predicted ferric reductases: mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity.
    Title: Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane monodehydroascorbate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ascorbate homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromaffin granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane ascorbate-dependent reductase CYB561
Names
CGCytb
chromaffin granule Cyt b561
cytochrome b561

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356374.1 → NP_001343303.1  transmembrane ascorbate-dependent reductase CYB561

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK158978, AL596246, AW985556
    Consensus CDS
    CCDS25542.1
    UniProtKB/Swiss-Prot
    Q3TEC6, Q60720, Q9D6C9
    UniProtKB/TrEMBL
    Q8CE89
    Conserved Domains (1) summary
    cl23723
    Location:43 → 184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  2. NM_007805.5 → NP_031831.2  transmembrane ascorbate-dependent reductase CYB561

    See identical proteins and their annotated locations for NP_031831.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK014395, AK028780, AL596246, AW985556
    Consensus CDS
    CCDS25542.1
    UniProtKB/Swiss-Prot
    Q3TEC6, Q60720, Q9D6C9
    UniProtKB/TrEMBL
    Q8CE89
    Related
    ENSMUSP00000019734.5, ENSMUST00000019734.11
    Conserved Domains (1) summary
    cl23723
    Location:43 → 184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105824528..105844157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156276.1 → XP_036012169.1  transmembrane ascorbate-dependent reductase CYB561 isoform X1

    Conserved Domains (1) summary
    cd08763
    Location:81 → 222
    Cyt_b561_CYB561; Vertebrate cytochrome b(561), CYB561 gene product

  2. XM_036156277.1 → XP_036012170.1  transmembrane ascorbate-dependent reductase CYB561 isoform X2

    UniProtKB/TrEMBL
    Q8CE89
    Conserved Domains (1) summary
    cl23723
    Location:53 → 194
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  3. XM_006532131.4 → XP_006532194.1  transmembrane ascorbate-dependent reductase CYB561 isoform X3

    See identical proteins and their annotated locations for XP_006532194.1

    UniProtKB/Swiss-Prot
    Q3TEC6, Q60720, Q9D6C9
    UniProtKB/TrEMBL
    Q8CE89
    Conserved Domains (1) summary
    cl23723
    Location:43 → 184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  4. XM_006532132.5 → XP_006532195.1  transmembrane ascorbate-dependent reductase CYB561 isoform X3

    See identical proteins and their annotated locations for XP_006532195.1

    UniProtKB/Swiss-Prot
    Q3TEC6, Q60720, Q9D6C9
    UniProtKB/TrEMBL
    Q8CE89
    Conserved Domains (1) summary
    cl23723
    Location:43 → 184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  5. XM_036156278.1 → XP_036012171.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Conserved Domains (1) summary
    cl23723
    Location:43 → 174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  6. XM_036156279.1 → XP_036012172.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Conserved Domains (1) summary
    cl23723
    Location:43 → 174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  7. XM_006532134.5 → XP_006532197.1  transmembrane ascorbate-dependent reductase CYB561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Related
    ENSMUSP00000138931.2, ENSMUST00000184086.8
    Conserved Domains (1) summary
    cl23723
    Location:43 → 174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60720.2 GenPept UniProtKB/Swiss-Prot:Q60720

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous