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Ctla2b cytotoxic T lymphocyte-associated protein 2 beta [ Mus musculus (house mouse) ]

Gene ID: 13025, updated on 3-Apr-2024

Summary

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Official Symbol
Ctla2bprovided by MGI
Official Full Name
cytotoxic T lymphocyte-associated protein 2 betaprovided by MGI
Primary source
MGI:MGI:88555
See related
Ensembl:ENSMUSG00000074874 AllianceGenome:MGI:88555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctla-2b
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including blood; extraembryonic component; female reproductive system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 17.6), liver E18 (RPKM 2.8) and 9 other tissues See more
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Genomic context

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Location:
13 B2; 13 32.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61043165..61045269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60895351..60897934, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin L-like 3 Neighboring gene STARR-seq mESC enhancer starr_34742 Neighboring gene RIKEN cDNA 4930486L24 gene Neighboring gene STARR-seq mESC enhancer starr_34743 Neighboring gene trophoblast specific protein beta Neighboring gene cytotoxic T lymphocyte-associated protein 2 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions. Denizot F, et al. Eur J Immunol, 1989 Apr. PMID 2786470
  2. Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion. Silva-Vilches C, et al. PLoS One, 2017. PMID 28759565, Free PMC Article
  3. Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. Cheon YP, et al. J Biol Chem, 2004 Mar 12. PMID 14681235
  4. Genetic, physical, and transcript map of the fld region on mouse chromosome 12. Péterfy M, et al. Genomics, 1999 Dec 15. PMID 10644441
  5. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Deussing J, et al. Genomics, 2002 Feb. PMID 11829493

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP
    Title: Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
  2. expression of CTLA-2beta in the decidua may regulate implantation of the embryo by neutralizing the activities of one or more proteases generated by the proliferating trophoblast
    Title: Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
protein CTLA-2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145801.2 → NP_001139273.1  protein CTLA-2-beta isoform b

    See identical proteins and their annotated locations for NP_001139273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC160962, CT010498
    Consensus CDS
    CCDS49288.1
    UniProtKB/TrEMBL
    A0A0R4J245, A0A286YD17
    Related
    ENSMUSP00000131083.2, ENSMUST00000171347.9
    Conserved Domains (1) summary
    smart00848
    Location:16 → 74
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

  2. NM_001428483.1 → NP_001415412.1  protein CTLA-2-beta isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160962, CT010498
    UniProtKB/Swiss-Prot
    P12400, Q3UBK9, Q541S2

  3. NM_007797.2 → NP_031823.1  protein CTLA-2-beta isoform a

    See identical proteins and their annotated locations for NP_031823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AC160962, CT010498
    Consensus CDS
    CCDS49289.1
    UniProtKB/Swiss-Prot
    P12400, Q3UBK9, Q541S2
    UniProtKB/TrEMBL
    A0A286YD17
    Related
    ENSMUSP00000021884.9, ENSMUST00000021884.10
    Conserved Domains (1) summary
    smart00848
    Location:16 → 74
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RNA

  1. NR_190375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC160962, CT010498

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61043165..61045269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244472.2 → XP_011242774.1  protein CTLA-2-beta isoform X1

    Conserved Domains (1) summary
    smart00848
    Location:16 → 74
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RNA

  1. XR_382421.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12400.2 GenPept UniProtKB/Swiss-Prot:P12400

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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