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Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Mus musculus (house mouse) ]

Gene ID: 13024, updated on 8-Feb-2024

Summary

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Official Symbol
Ctla2aprovided by MGI
Official Full Name
cytotoxic T lymphocyte-associated protein 2 alphaprovided by MGI
Primary source
MGI:MGI:88554
See related
Ensembl:ENSMUSG00000044258 AllianceGenome:MGI:88554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctla-2a
Summary
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within negative regulation of inflammatory response; negative regulation of protein processing; and regulation of regulatory T cell differentiation. Located in dendrite. Is expressed in several structures, including blood; cerebral cortex; esophagus; genitourinary system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 179.4) and lung adult (RPKM 12.9) See more
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Genomic context

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Location:
13 B2; 13 32.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61081969..61084439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60934155..60936625, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytotoxic T lymphocyte-associated protein 2 beta Neighboring gene trophoblast specific protein beta Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40976 Neighboring gene predicted gene, 40975

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Zhang L, et al. Cell Signal, 2011 Oct. PMID 21620962, Free PMC Article
  2. Dendritic and axonal localization of cytotoxic T-lymphocyte antigen-2 alpha protein in mouse brain. Luziga C, et al. Brain Res, 2008 Apr 14. PMID 18342295
  3. Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain. Luziga C, et al. Acta Histochem, 2016 Sep. PMID 27586811
  4. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. Sugita S, et al. J Immunol, 2009 Oct 15. PMID 19801522
  5. Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions. Denizot F, et al. Eur J Immunol, 1989 Apr. PMID 2786470

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTLA-2 secretion is induced by dendritic cells to enhance regulatory T cell conversion after administration of cholera toxin and cAMP
    Title: Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.
  2. that the fine equilibrium between synthesis and secretion of cathespin L and CTLA-2alpha is part of the brain processes to maintain normal growth and development
    Title: Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.
  3. Double immunofluorescence analysis showed that CTLA-2alpha was co-localized with cathepsin L, cathepsin C, and TINAGL1 in placenta.
    Title: Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α.
  4. cAMP increases CTLA-2alpha expression in murine lymphoma and cardiac fibroblasts, and this increase in CTLA-2alpha contributes to cAMP/PKA-promoted apoptosis by mechanisms that are independent of the ability of CTLA-2alpha to inhibit cathepsin L.
    Title: Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein CTLA-2-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145799.1 → NP_001139271.1  protein CTLA-2-alpha isoform b

    See identical proteins and their annotated locations for NP_001139271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA451288, AK018801, AK132290
    UniProtKB/TrEMBL
    A0A286YDF0
    Conserved Domains (1) summary
    smart00848
    Location:16 → 74
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

  2. NM_007796.2 → NP_031822.2  protein CTLA-2-alpha isoform a precursor

    See identical proteins and their annotated locations for NP_031822.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK132290, AK167433, BB574774
    Consensus CDS
    CCDS49290.1
    UniProtKB/Swiss-Prot
    P12399, Q91V07
    UniProtKB/TrEMBL
    A0A286YDF0
    Related
    ENSMUSP00000021880.10, ENSMUST00000021880.10
    Conserved Domains (1) summary
    smart00848
    Location:40 → 98
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61081969..61084439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12399.2 GenPept UniProtKB/Swiss-Prot:P12399

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