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Csrp1 cysteine and glycine-rich protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13007, updated on 21-Apr-2024

Summary

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Official Symbol
Csrp1provided by MGI
Official Full Name
cysteine and glycine-rich protein 1provided by MGI
Primary source
MGI:MGI:88549
See related
Ensembl:ENSMUSG00000026421 AllianceGenome:MGI:88549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRP1; Csrp
Summary
Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development and sarcomere organization. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1668.6), stomach adult (RPKM 304.4) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 59.23 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135614650..135679970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135720063..135752229)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuron navigator 1 Neighboring gene predicted gene, 32940 Neighboring gene predicted gene 4793 Neighboring gene STARR-seq mESC enhancer starr_02376 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene STARR-seq mESC enhancer starr_02392 Neighboring gene pleckstrin homology like domain, family A, member 3 Neighboring gene STARR-seq mESC enhancer starr_02394 Neighboring gene troponin I, skeletal, slow 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: the Chicago health, aging, and social relations study. McDade TW, et al. Psychosom Med, 2006 May-Jun. PMID 16738067
  2. The LIM protein, CRP1, is a smooth muscle marker. Henderson JR, et al. Dev Dyn, 1999 Mar. PMID 10090149
  3. Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Lilly B, et al. Arterioscler Thromb Vasc Biol, 2010 Apr. PMID 20056913, Free PMC Article
  4. Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice. Snider P, et al. Genesis, 2008 Mar. PMID 18327771
  5. Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. Wang X, et al. J Biol Chem, 1992 May 5. PMID 1374386

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Csrp1 is not essential for normal smooth muscle differentiation during development, but may modulate the smooth muscle response to pathophysiological stress.
    Title: Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.
  2. This ECsrp1(Cre) transgenic line should thus prove useful for genetic analysis of diverse aspects of cardiovascular morphogenesis.
    Title: Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine and glycine-rich protein 1
Names
CRP
cysteine rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360782.2 → NP_001347711.1  cysteine and glycine-rich protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    Consensus CDS
    CCDS15320.1
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4
    Related
    ENSMUSP00000095169.3, ENSMUST00000097561.9
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

  2. NM_001420086.1 → NP_001407015.1  cysteine and glycine-rich protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4

  3. NM_001420087.1 → NP_001407016.1  cysteine and glycine-rich protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4

  4. NM_001420088.1 → NP_001407017.1  cysteine and glycine-rich protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4

  5. NM_001420089.1 → NP_001407018.1  cysteine and glycine-rich protein 1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4

  6. NM_007791.7 → NP_031817.1  cysteine and glycine-rich protein 1

    See identical proteins and their annotated locations for NP_031817.1

    Status: VALIDATED

    Source sequence(s)
    AC162441
    Consensus CDS
    CCDS15320.1
    UniProtKB/Swiss-Prot
    P97315
    UniProtKB/TrEMBL
    Q4FJX4
    Related
    ENSMUSP00000027677.8, ENSMUST00000027677.8
    Conserved Domains (2) summary
    cd09403
    Location:119 → 172
    LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
    cd09479
    Location:8 → 63
    LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

RNA

  1. NR_153810.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC162441

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135614650..135679970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97315.3 GenPept UniProtKB/Swiss-Prot:P97315

Gene LinkOut

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