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Csnk2b casein kinase 2, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13001, updated on 21-Apr-2024

Summary

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Official Symbol
Csnk2bprovided by MGI
Official Full Name
casein kinase 2, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88548
See related
Ensembl:ENSMUSG00000024387 AllianceGenome:MGI:88548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK II beta
Summary
This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Broad expression in testis adult (RPKM 540.1), duodenum adult (RPKM 75.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.59 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35335171..35341029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35116195..35122053, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene predicted gene 20522 Neighboring gene DNA segment, Chr 17, human D6S53E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice. Liang QX, et al. Cell Prolif, 2020 Jan. PMID 31755150, Free PMC Article
  2. A proteomics analysis of CK2β((-/-)) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit. Borgo C, et al. FEBS J, 2019 Apr. PMID 30834696
  3. Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure. Liang QX, et al. Cell Death Dis, 2018 May 1. PMID 29725001, Free PMC Article
  4. CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis. Münzer P, et al. Blood, 2017 Dec 21. PMID 28928125
  5. Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Bragdon B, et al. Biophys J, 2010 Aug 4. PMID 20682268, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
    Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
  2. Results found that the regulatory CK2 beta subunits are essential for GN11 neuronal cell migration and their deletion induces deep changes in cytoskeletal structures that totally prevent cell migration.
    Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
  3. pool of ecto-CK2 is not apparently affected by the lack of the beta-subunit
    Title: A proteomics analysis of CK2β((-/-)) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit.
  4. Ablation of Ck2beta gene triggered excessive germ cell apoptosis, germ cell development arrest, azoospermia and male infertility. Inactivation of Ck2beta gene caused distinctly reduced expression of Ck2alpha' gene and CK2alpha' protein.
    Title: Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice.
  5. Oocyte-specific deletion of CK2beta causes follicular atresia and premature ovarian failure in mice.
    Title: Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure.
  6. GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons.
    Title: Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.
  7. thrombotic vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time
    Title: CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis.
  8. AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury.
    Title: AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β.
  9. These data suggest that CK2 is a negative regulator of BMP signaling and osteoblast differentiation.
    Title: Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling.
  10. Data suggest that CK2beta appears to play an essential and uncompensated role in central nervous system development.
    Title: Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Ly6g5b

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in symbiont-mediated disruption of host cell PML body ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
casein kinase II subunit beta
Names
phosvitin
NP_001290374.1
NP_001290375.1
NP_001290405.1
NP_034105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303445.1 → NP_001290374.1  casein kinase II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001290374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28684.1
    UniProtKB/Swiss-Prot
    P67871, Q3TTJ7
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000134218.2, ENSMUST00000173114.8
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

  2. NM_001303446.1 → NP_001290375.1  casein kinase II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001290375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000134523.3, ENSMUST00000172765.9
    Conserved Domains (1) summary
    smart01085
    Location:29 → 212
    CK_II_beta; Casein kinase II regulatory subunit

  3. NM_001303476.1 → NP_001290405.1  casein kinase II subunit beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region compared to variant 1, including initiation of translation at a downstream start codon. It encodes isoform 3, which is longer than isoform 1 and has a shorter N-terminus and a distinct C-terminus.
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS79541.1
    UniProtKB/TrEMBL
    G3UZX4
    Related
    ENSMUSP00000134673.2, ENSMUST00000174024.8
    Conserved Domains (1) summary
    smart01085
    Location:8 → 129
    CK_II_beta; Casein kinase II regulatory subunit

  4. NM_009975.3 → NP_034105.1  casein kinase II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_034105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28684.1
    UniProtKB/Swiss-Prot
    P67871, Q3TTJ7
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000025246.7, ENSMUST00000025246.13
    Conserved Domains (1) summary
    smart01085
    Location:8 → 191
    CK_II_beta; Casein kinase II regulatory subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35335171..35341029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P67871.1 GenPept UniProtKB/Swiss-Prot:P67871

Gene LinkOut

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