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Csnk2a1 casein kinase 2, alpha 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12995, updated on 3-Apr-2024

Summary

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Official Symbol
Csnk2a1provided by MGI
Official Full Name
casein kinase 2, alpha 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88543
See related
Ensembl:ENSMUSG00000074698 AllianceGenome:MGI:88543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK2; CK II alpha; Csnk2a1-rs4
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.4), whole brain E14.5 (RPKM 26.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.83 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152068468..152123772)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152226535..152281856)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_06046 Neighboring gene STARR-seq mESC enhancer starr_06048 Neighboring gene ribosomal protein S15A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_06049 Neighboring gene STARR-seq mESC enhancer starr_06050 Neighboring gene STARR-positive B cell enhancer ABC_E6001 Neighboring gene STARR-seq mESC enhancer starr_06051 Neighboring gene STARR-seq mESC enhancer starr_06052 Neighboring gene STARR-positive B cell enhancer ABC_E10153 Neighboring gene TBC1 domain family, member 20 Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition. Shu C, et al. J Endocrinol Invest, 2023 Mar. PMID 36306106, Free PMC Article
  2. A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability. Borgo C, et al. Biochem Biophys Res Commun, 2020 Oct 20. PMID 32800562
  3. Up-Regulation of the Alpha Prime Subunit of Protein Kinase CK2 as a Marker of Fast Proliferation in GL261 Cultured Cells. Villamañan L, et al. Pathol Oncol Res, 2019 Oct. PMID 30607803
  4. FcγR/ROS/CK2α Is the Key Inducer of NF-κB Activation in a Murine Model of Asthma. Kim JM, et al. Int Arch Allergy Immunol, 2018. PMID 29339659
  5. CK2 Oppositely Modulates l-DOPA-Induced Dyskinesia via Striatal Projection Neurons Expressing D1 or D2 Receptors. Cortés M, et al. J Neurosci, 2017 Dec 6. PMID 29097596, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.
    Title: CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.
  2. A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
    Title: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
  3. Protein Kinase CK2 Regulates B Cell Development and Differentiation.
    Title: Protein Kinase CK2 Regulates B Cell Development and Differentiation.
  4. Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
    Title: Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
  5. Phosphorylation of Syntaxin-1a by casein kinase 2alpha regulates pre-synaptic vesicle exocytosis from the reserve pool.
    Title: Phosphorylation of Syntaxin-1a by casein kinase 2α regulates pre-synaptic vesicle exocytosis from the reserve pool.
  6. A N-terminally deleted form of the CK2alpha' catalytic subunit is sufficient to support cell viability.
    Title: A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability.
  7. Down-regulation of CK2alpha correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes.
    Title: Down-regulation of CK2α correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes.
  8. beta-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
    Title: β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
  9. Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
    Title: Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.
  10. Results find that CK2alpha subunit has no role in GN11 neuronal cell adhesion or migration.
    Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of Sin3-type complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein kinase CK2 complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
casein kinase II subunit alpha
Names
casein kinase II, alpha 1 polypeptide
casein kinase II, alpha 1 related sequence 4
NP_001403894.1
NP_001403895.1
NP_001403896.1
NP_001403897.1
NP_001403898.1
NP_001403899.1
NP_001403900.1
NP_001403901.1
NP_001403902.1
NP_001403903.1
NP_031814.2
XP_011237574.1
XP_030102934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416965.1 → NP_001403894.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  2. NM_001416966.1 → NP_001403895.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  3. NM_001416967.1 → NP_001403896.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  4. NM_001416968.1 → NP_001403897.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  5. NM_001416969.1 → NP_001403898.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  6. NM_001416970.1 → NP_001403899.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  7. NM_001416971.1 → NP_001403900.1  casein kinase II subunit alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL831735
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4

  8. NM_001416972.1 → NP_001403901.1  casein kinase II subunit alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL831735

  9. NM_001416973.1 → NP_001403902.1  casein kinase II subunit alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL831735

  10. NM_001416974.1 → NP_001403903.1  casein kinase II subunit alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL831735

  11. NM_007788.4 → NP_031814.2  casein kinase II subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_031814.2

    Status: VALIDATED

    Source sequence(s)
    AL831735
    Consensus CDS
    CCDS16879.1
    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Related
    ENSMUSP00000096829.4, ENSMUST00000099224.10
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152068468..152123772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247074.2 → XP_030102934.1  casein kinase II subunit alpha isoform X1

    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  2. XM_011239272.4 → XP_011237574.1  casein kinase II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_011237574.1

    UniProtKB/Swiss-Prot
    Q60737, Q8R0X4
    UniProtKB/TrEMBL
    Q61177
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60737.2 GenPept UniProtKB/Swiss-Prot:Q60737

Gene LinkOut

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