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Csn1s2b casein alpha s2-like B [ Mus musculus (house mouse) ]

Gene ID: 12992, updated on 8-Feb-2024

Summary

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Official Symbol
Csn1s2bprovided by MGI
Official Full Name
casein alpha s2-like Bprovided by MGI
Primary source
MGI:MGI:105312
See related
Ensembl:ENSMUSG00000061388 AllianceGenome:MGI:105312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csnd; Csne
Summary
This gene is a member of the alpha-s2-like casein gene family, and this gene product is a calcium-sensitive casein. Members of this gene family are organized as a gene cluster that is conserved in its order, but with greater conservation amongst orthologs than paralogs. The protein encoded by this gene interacts with other casein proteins to form a micelle structure, and is a major source of protein in milk. This structure is important for the transport of calcium, phosphate, and protein. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Csn1s2b in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87955980..87972280)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87808121..87824421)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24314 Neighboring gene STARR-seq mESC enhancer starr_13563 Neighboring gene casein alpha s2-like A Neighboring gene STARR-seq mESC enhancer starr_13564 Neighboring gene proline rich 27 Neighboring gene DAZ interacting protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland. Lee HK, et al. Nat Commun, 2021 Apr 14. PMID 33854063, Free PMC Article
  2. Nucleotide sequence of cloned cDNA coding for mouse epsilon casein. Hennighausen LG, et al. Eur J Biochem, 1982 Sep 1. PMID 6897225
  3. Physical mapping of the murine casein locus reveals the gene order as alpha-beta-gamma-epsilon-kappa. George S, et al. DNA Cell Biol, 1997 Apr. PMID 9150435
  4. Restriction map of two yeast artificial chromosomes spanning the murine casein locus. Tomlinson AM, et al. Mamm Genome, 1996 Jul. PMID 8672136
  5. Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. Hennighausen LG, et al. Eur J Biochem, 1982 Jun 15. PMID 6896688

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland.
    Title: Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zymogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-S2-casein-like B
Names
casein delta
epsilon-casein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301334.1 → NP_001288263.1  alpha-S2-casein-like B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001288263.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK085744, AK164763, AK164767
    Consensus CDS
    CCDS80319.1
    UniProtKB/TrEMBL
    Q3TP31
    Related
    ENSMUSP00000108904.2, ENSMUST00000113279.8
    Conserved Domains (1) summary
    pfam00363
    Location:60 → 120
    Casein; Casein

  2. NM_001301335.1 → NP_001288264.1  alpha-S2-casein-like B isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AK085744, AK164767
    Consensus CDS
    CCDS80320.1
    UniProtKB/TrEMBL
    A0A0G2JDP4
    Related
    ENSMUSP00000142449.2, ENSMUST00000197301.2
    Conserved Domains (1) summary
    pfam00363
    Location:49 → 121
    Casein; Casein

  3. NM_009973.3 → NP_034103.2  alpha-S2-casein-like B isoform 1 precursor

    See identical proteins and their annotated locations for NP_034103.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK085744, AK164767
    Consensus CDS
    CCDS39133.1
    UniProtKB/Swiss-Prot
    P02664, Q3TP28, Q3TP29, Q542L5
    Related
    ENSMUSP00000072352.6, ENSMUST00000072539.12
    Conserved Domains (1) summary
    pfam00363
    Location:60 → 132
    Casein; Casein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    87955980..87972280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02664.1 GenPept UniProtKB/Swiss-Prot:P02664

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