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Csn1s1 casein alpha s1 [ Mus musculus (house mouse) ]

Gene ID: 12990, updated on 5-Mar-2024

Summary

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Official Symbol
Csn1s1provided by MGI
Official Full Name
casein alpha s1provided by MGI
Primary source
MGI:MGI:88540
See related
Ensembl:ENSMUSG00000070702 AllianceGenome:MGI:88540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csna
Summary
Predicted to be involved in response to dehydroepiandrosterone; response to estradiol; and response to steroid hormone. Located in extracellular region. Is expressed in embryo and mammary gland. Orthologous to human CSN1S1 (casein alpha s1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
5 E1; 5 43.56 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87814067..87830437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87666208..87682578)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microRNA 3969 Neighboring gene pleckstrin and Sec7 domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13561 Neighboring gene STARR-seq mESC enhancer starr_13562 Neighboring gene casein beta Neighboring gene predicted gene, 25066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evaluation of the α-casein (CSN1S1) locus as a potential target for a site-specific transgene integration. Smirnov AV, et al. Sci Rep, 2022 May 14. PMID 35568783, Free PMC Article
  2. Milk lacking α-casein leads to permanent reduction in body size in mice. Kolb AF, et al. PLoS One, 2011. PMID 21789179, Free PMC Article
  3. Casein expression in cytotoxic T lymphocytes. Grusby MJ, et al. Proc Natl Acad Sci U S A, 1990 Sep. PMID 2395885, Free PMC Article
  4. Characterization of three types of human alpha s1-casein mRNA transcripts. Johnsen LB, et al. Biochem J, 1995 Jul 1. PMID 7619062, Free PMC Article
  5. Expression analysis of the individual bovine beta-, alpha s2- and kappa-casein genes in transgenic mice. Rijnkels M, et al. Biochem J, 1995 Nov 1. PMID 7487953, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of the milk protein alpha-casein by inactivating the corresponding gene in mice, was analysed.
    Title: Milk lacking α-casein leads to permanent reduction in body size in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in response to 11-deoxycorticosterone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to dehydroepiandrosterone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estradiol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to progesterone IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha-S1-casein
Names
alpha-casein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286015.1 → NP_001272944.1  alpha-S1-casein isoform b precursor

    See identical proteins and their annotated locations for NP_001272944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK052808, BE335666, M36780
    UniProtKB/TrEMBL
    Q99JM6, Q99M19
    Conserved Domains (1) summary
    pfam00363
    Location:209 → 284
    Casein; Casein

  2. NM_001286016.1 → NP_001272945.1  alpha-S1-casein isoform c precursor

    See identical proteins and their annotated locations for NP_001272945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK052808, BE335666, M36780
    Consensus CDS
    CCDS80314.1
    UniProtKB/TrEMBL
    Q91VV1, Q99M19
    Related
    ENSMUSP00000142794.2, ENSMUST00000197631.5
    Conserved Domains (1) summary
    pfam00363
    Location:217 → 268
    Casein; Casein

  3. NM_007784.3 → NP_031810.1  alpha-S1-casein isoform a precursor

    See identical proteins and their annotated locations for NP_031810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK052808, BE335666, M36780
    Consensus CDS
    CCDS51534.1
    UniProtKB/Swiss-Prot
    P19228
    UniProtKB/TrEMBL
    Q99M19
    Related
    ENSMUSP00000092225.5, ENSMUST00000094641.9
    Conserved Domains (1) summary
    pfam00363
    Location:217 → 292
    Casein; Casein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    87814067..87830437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19228.1 GenPept UniProtKB/Swiss-Prot:P19228

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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