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Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [ Mus musculus (house mouse) ]

Gene ID: 12984, updated on 11-Apr-2024

Summary

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Official Symbol
Csf2rb2provided by MGI
Official Full Name
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)provided by MGI
Primary source
MGI:MGI:1339760
See related
Ensembl:ENSMUSG00000071714 AllianceGenome:MGI:1339760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bil3; Il3r; AIC2A; Il3rb; Il3rb2; BetaIl3; Csfgmrb
Summary
Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Located in plasma membrane. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 26.5), spleen adult (RPKM 9.9) and 15 other tissues See more
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Genomic context

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Location:
15 E1; 15 37.22 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78166707..78189921, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78282507..78305721, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene parvalbumin Neighboring gene STARR-seq mESC enhancer starr_39140 Neighboring gene STARR-seq mESC enhancer starr_39141 Neighboring gene STARR-positive B cell enhancer ABC_E2443 Neighboring gene STARR-positive B cell enhancer ABC_E9914 Neighboring gene neutrophil cytosolic factor 4 Neighboring gene microRNA 7676-1 Neighboring gene colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) Neighboring gene microRNA 7676-2 Neighboring gene ciliary microtubule inner protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation. Carr PD, et al. Biochem J, 2014 Nov 1. PMID 25137390
  2. Functional inactivation in mice of the gene for the interleukin-3 (IL-3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells. Nicola NA, et al. Blood, 1996 Apr 1. PMID 8639882
  3. AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A structure. Schreurs J, et al. Int Immunol, 1991 Dec. PMID 1777419
  4. Structure of mouse interleukin 3 (IL-3) binding protein (AIC2A). Amino acid residues critical for IL-3 binding. Wang HM, et al. J Biol Chem, 1992 Jan 15. PMID 1730686
  5. The IL-3/IL-5/GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation. Asquith KL, et al. J Immunol, 2008 Jan 15. PMID 18178860

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The beta chain cytokine receptor Csf2rb2 was identified as a downstream molecule of Notch signaling in hematopoietic cells.
    Title: Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.
  2. Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.
    Title: Identification of potential biomarkers for post-traumatic complications released after trauma-hemorrhage from murine Kupffer cells and its investigation in lung and liver.
  3. this receptor adopts an arch-like intertwined homodimeric structure
    Title: Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation.
  4. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling
    Title: The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.
  5. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms.
    Title: Two modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.
  6. Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts.
    Title: BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.
  7. IL-3-driven survival and proliferation is negatively regulated, potentially via tyrosine phosphorylation of Aic2A and STAT5
    Title: Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-3-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-5-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-3 receptor class 2 subunit beta
Names
IL-3 receptor class 2 subunit beta
IL-3R class 2 subunit beta
colony-stimulating factor 2 receptor subunit beta-2
interleukin-3 receptor class II beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287389.1 → NP_001274318.1  interleukin-3 receptor class 2 subunit beta isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK155626, AL589692, BY208313
    Consensus CDS
    CCDS88799.1
    UniProtKB/TrEMBL
    A0A2R8VHE8, Q3U1Z1
    Related
    ENSMUSP00000155013.3, ENSMUST00000230115.3
    Conserved Domains (2) summary
    cd00063
    Location:245 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:140 → 218
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_007781.3 → NP_031807.1  interleukin-3 receptor class 2 subunit beta isoform 1 precursor

    See identical proteins and their annotated locations for NP_031807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL589692
    Consensus CDS
    CCDS27611.1
    UniProtKB/Swiss-Prot
    P26954
    UniProtKB/TrEMBL
    Q3U241
    Related
    ENSMUSP00000094083.4, ENSMUST00000096356.5
    Conserved Domains (3) summary
    smart00060
    Location:137 → 225
    FN3; Fibronectin type 3 domain
    cd00063
    Location:354 → 438
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:249 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78166707..78189921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26954.1 GenPept UniProtKB/Swiss-Prot:P26954

Gene LinkOut

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