Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csf2rbprovided by MGI
Official Full Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)provided by MGI
Primary source: MGI:MGI:1339759
See related: Ensembl:ENSMUSG00000071713 AllianceGenome:MGI:1339759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bc; Il3r; AIC2B; Il3rb; Il5rb; CDw131; Il3rb1; Csf2rb1; Csfgmrb
Summary: Predicted to enable cytokine receptor activity. Acts upstream of or within cytokine-mediated signaling pathway and regulation of cell growth. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including bone marrow; cardiovascular system mesenchyme; dorsal aorta; genitourinary system; and yolk sac. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 30.9), spleen adult (RPKM 19.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.36 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78210000..78235201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78325800..78351001)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury.
Title: CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury.
The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.
Title: The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.
This study demonstrates that induced pluripotent stem cell-derived macrophages effectively treat pulmonary alveolar proteinosis in Csf2rb-deficient mice after pulmonary transplantation.
Title: iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
IL-3 signaling does not contribute to Jak2 V617F myeloproliferative neoplasm pathogenesis.
Title: Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signaling.
blockage of betaCR abrogated the EPO-conferred anti-inflammatory action on oxLDL-induced production of macrophage inflammatory protein-2
Title: β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages.
Deletion of the Csf2rb gene slows the progression of chronic myelomonocytic leukemia in mice.
Title: Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.
Increased levels of Csf2rb on hematopoietic stem cells lead to expansion of these populations in ApoE(-/-) BM-transplanted Ldlr(-/-) mice, contributing to monocytosis and increased lesional macrophage content.
Title: Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency.
Erythropoietin attenuates the impaired systolic contractility associated with sepsis by activation of the beta-common receptor.
Title: Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor.
Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor.
Title: SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
Csf-2 receptor acts in the steady state to promote the survival & homeostasis of nonlymphoid tissue-resident CD103(+) & CD11b(+) DCs. It is dispensable for the differentiation & innate function of inflammatory DCs during acute injuries.
Title: GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M34397 (e-PCR)
- UniSTS:180792

AI848964 (e-PCR)
- UniSTS:180795

Csf2rb (e-PCR), detects polymorphism
- UniSTS:256860

Csf2rb1 (e-PCR), detects polymorphism
- UniSTS:141413

Csf2rb (e-PCR), detects polymorphism
- UniSTS:265070

Csf2rb (e-PCR), detects polymorphism
- UniSTS:265071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of granulocyte macrophage colony-stimulating factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytokine receptor common subunit beta

Names: CD131 antigen; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; beta c; colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage); common beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358854.1 → NP_001345783.1 cytokine receptor common subunit beta precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL583893

Consensus CDS

CCDS27612.1

UniProtKB/Swiss-Prot

P26955, Q3U7L5

UniProtKB/TrEMBL

Q3U2T6, Q8QZX9

Related

ENSMUSP00000154836.2, ENSMUST00000230264.3

Conserved Domains (3) summary

cd00063
Location:346 → 439

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:250 → 316

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl26464
Location:551 → 809

Atrophin-1; Atrophin-1 family
NM_007780.4 → NP_031806.3 cytokine receptor common subunit beta precursor

See identical proteins and their annotated locations for NP_031806.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI467222, AK152608, AL583893

Consensus CDS

CCDS27612.1

UniProtKB/Swiss-Prot

P26955, Q3U7L5

UniProtKB/TrEMBL

Q3U2T6, Q8QZX9

Related

ENSMUSP00000094082.4, ENSMUST00000096355.4

Conserved Domains (3) summary

cd00063
Location:346 → 439

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:250 → 316

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl26464
Location:551 → 809

Atrophin-1; Atrophin-1 family