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Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Mus musculus (house mouse) ]

Gene ID: 12982, updated on 11-Apr-2024

Summary

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Official Symbol
Csf2raprovided by MGI
Official Full Name
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)provided by MGI
Primary source
MGI:MGI:1339754
See related
Ensembl:ENSMUSG00000059326 AllianceGenome:MGI:1339754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD116; Csfgmra; GM-CSFR; GM-CSF-Ra
Summary
Enables granulocyte colony-stimulating factor binding activity and granulocyte colony-stimulating factor receptor activity. Acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus. Located in plasma membrane. Is expressed in early conceptus; female reproductive system; and liver. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RA (colony stimulating factor 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 16.7), adrenal adult (RPKM 15.6) and 28 other tissues See more
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Genomic context

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Location:
19 D3; 19 56.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (61205629..61221141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (61217191..61228461, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6020 Neighboring gene STARR-positive B cell enhancer ABC_E10002 Neighboring gene mortality factor 4 like 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr19:61257593-61257894 Neighboring gene M-phase specific PLK1 intereacting protein like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5715 Neighboring gene STARR-positive B cell enhancer ABC_E7682 Neighboring gene STARR-positive B cell enhancer ABC_E9054 Neighboring gene STARR-positive B cell enhancer ABC_E7683 Neighboring gene STARR-positive B cell enhancer ABC_E2533 Neighboring gene predicted gene 4242 Neighboring gene STARR-positive B cell enhancer ABC_E5716 Neighboring gene DCP1 decapping enzyme homolog A pseudogene Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene predicted gene, 20762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF. Nishijima I, et al. Mol Biol Cell, 1995 May. PMID 7545029, Free PMC Article
  2. A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption. Shima K, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Mar 1. PMID 35043685, Free PMC Article
  3. Neutrophil GM-CSF receptor dynamics in acute lung injury. De Alessandris S, et al. J Leukoc Biol, 2019 Jun. PMID 30942918, Free PMC Article
  4. Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling. Hui Z, et al. Front Immunol, 2018. PMID 30154795, Free PMC Article
  5. Targeting the GM-CSF receptor for the treatment of CNS autoimmunity. Ifergan I, et al. J Autoimmun, 2017 Nov. PMID 28641926, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.
    Title: A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption.
  2. These data show that loss of membrane GM-CSFRalpha following GM-CSF exposure does not preclude sustained GM-CSF/GM-CSFRalpha signaling and that this receptor plays a key role in ligand clearance. Hence neutrophilic activation via GM-CSFR may play an important role in neutrophilic lung inflammation even in the absence of high GM-CSF levels or GM-CSFRalpha expression.
    Title: Neutrophil GM-CSF receptor dynamics in acute lung injury.
  3. we have demonstrated that CFP1 plays a crucial role in GM-CSF-derived macrophages, in which it positively regulates phagocytic and bactericidal activity mainly through promoting Csf2ralpha expression and the subsequent activation of downstream pathways.
    Title: Cxxc Finger Protein 1 Positively Regulates GM-CSF-Derived Macrophage Phagocytosis Through Csf2rα-Mediated Signaling.
  4. GM-CSF Ralpha blockade in relapsing-remitting experimental autoimmune encephalomyelitis prevented disease relapses and inhibited T cell responses specific for both the inducing and spread myelin peptides
    Title: Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.
  5. a STOP mutation in the GM-CSFRalpha chain, leading to a complete and specific deficiency in GM-CSF signaling, is reported.
    Title: Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection.
  6. GM-CSFRalpha levels peaked between E13 and E15 in the brain.
    Title: Stage-specific changes in the levels of granulocyte-macrophage colony-stimulating factor and its receptor in the biological fluid and organ of mouse fetuses.
  7. Loss of the CSF2RA gene may be a critical mutation explaining the high incidence of loss of sex chromosomes associated with the t(8;21)(q22;q22) translocation.
    Title: Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.
  8. ability to detect GM-CSF receptor expression in experimental studies should greatly facilitate the analysis of its role in immune pathologies[GM-CSF receptor alpha]
    Title: Characterisation of the expression and function of the GM-CSF receptor alpha-chain in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Names
GM-CSF-R-alpha
GM-CSFRalpha
GMCSFR-alpha
GMR-alpha
colony stimulating factor 2 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009970.2 → NP_034100.2  granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_034100.2

    Status: VALIDATED

    Source sequence(s)
    AW826169, BB664140, BU614102, M85078
    Consensus CDS
    CCDS29946.1
    UniProtKB/Swiss-Prot
    E9QJX0, Q00941
    UniProtKB/TrEMBL
    B2RWT6
    Related
    ENSMUSP00000075423.7, ENSMUST00000076046.7
    Conserved Domains (2) summary
    cd00063
    Location:227 → 315
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:130 → 223
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    61205629..61221141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161420.1 → XP_036017313.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X7

    Conserved Domains (2) summary
    cd00063
    Location:53 → 141
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:1 → 49
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_036161419.1 → XP_036017312.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X6

    Conserved Domains (2) summary
    cd00063
    Location:53 → 141
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:1 → 49
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_017318052.3 → XP_017173541.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4

    UniProtKB/TrEMBL
    B2RWT6
    Conserved Domains (3) summary
    cd00063
    Location:259 → 337
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:164 → 255
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:74 → 143
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  4. XM_011247131.4 → XP_011245433.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    B2RWT6
    Conserved Domains (3) summary
    cd00063
    Location:259 → 337
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:164 → 255
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:74 → 143
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  5. XM_011247130.4 → XP_011245432.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    B2RWT6
    Conserved Domains (3) summary
    cd00063
    Location:259 → 347
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:164 → 255
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:74 → 143
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  6. XM_011247132.4 → XP_011245434.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X3

    Conserved Domains (2) summary
    pfam09240
    Location:164 → 255
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:74 → 143
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

  7. XM_036161418.1 → XP_036017311.1  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X5

    Conserved Domains (2) summary
    pfam09240
    Location:164 → 255
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    pfam18611
    Location:74 → 140
    IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

RNA

  1. XR_877658.4 RNA Sequence

  2. XR_003952748.2 RNA Sequence

  3. XR_003952745.2 RNA Sequence

  4. XR_004940112.1 RNA Sequence

  5. XR_003952744.2 RNA Sequence

  6. XR_003952743.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00941.2 GenPept UniProtKB/Swiss-Prot:Q00941

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