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Crygs crystallin, gamma S [ Mus musculus (house mouse) ]

Gene ID: 12970, updated on 5-Mar-2024

Summary

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Official Symbol
Crygsprovided by MGI
Official Full Name
crystallin, gamma Sprovided by MGI
Primary source
MGI:MGI:1298216
See related
Ensembl:ENSMUSG00000033501 AllianceGenome:MGI:1298216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opj; rncat
Summary
A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye and morphogenesis of an epithelium. Is expressed in alimentary system; eye; and genitourinary system. Used to study cataract 20 multiple types. Human ortholog(s) of this gene implicated in cataract 20 multiple types. Orthologous to human CRYGS (crystallin gamma S). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Crygs in Genome Data Viewer
Location:
16 B1; 16 13.66 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22623953..22630160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22805203..22811410, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, gamma Neighboring gene STARR-seq mESC enhancer starr_40416 Neighboring gene STARR-positive B cell enhancer mm9_chr16:22633282-22633583 Neighboring gene microRNA 6362 Neighboring gene STARR-seq mESC enhancer starr_40417 Neighboring gene STARR-positive B cell enhancer ABC_E5532 Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 30416 Neighboring gene TBCC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E484 Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene predicted gene, 30505

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alterations to proteins in the lens of hereditary Crygs-mutated cataractous mice. Ji Y, et al. Mol Vis, 2010 Jun 11. PMID 20596256, Free PMC Article
  2. Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR. Wu Z, et al. Protein Sci, 2005 Dec. PMID 16260758, Free PMC Article
  3. A temperature-sensitive mutation of Crygs in the murine Opj cataract. Sinha D, et al. J Biol Chem, 2001 Mar 23. PMID 11121426
  4. A role for γS-crystallin in the organization of actin and fiber cell maturation in the mouse lens. Fan J, et al. FEBS J, 2012 Aug. PMID 22715935, Free PMC Article
  5. The gamma S-crystallin gene is mutated in autosomal recessive cataract in mouse. Bu L, et al. Genomics, 2002 Jul. PMID 12079281

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gammaS may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation
    Title: A role for γS-crystallin in the organization of actin and fiber cell maturation in the mouse lens.
  2. Mutant Crygs gene can lead to changes of BFSP/filensin and other crystallins. Changes to these crystallins, together, may secondarily lead to cataract formation.
    Title: Alterations to proteins in the lens of hereditary Crygs-mutated cataractous mice.
  3. gammaS consists of two topologically similar domains, arranged with an approximate twofold symmetry, and each domain shows close structural homology to closely related domains found in other members of the gamma-crystallin family.
    Title: Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR.
  4. disruption of the Hsf4 gene leads to cataracts via at least three pathways: down-regulation of gamma-crystallin, particularly gamma S-crystallin; decreased lens beaded filament expression; and loss of post-translational modification of alpha A-crystallin
    Title: Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.
  5. mutation causes autosomal recessive cataracts; likely to be involved in epithelial cell proliferation, apoptosis, and migration
    Title: The gamma S-crystallin gene is mutated in autosomal recessive cataract in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-crystallin S
Names
beta-crystallin S
opacity due to poor secondary fiber cell junction
recessive nuclear cataract

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009967.2 → NP_034097.1  gamma-crystallin S

    See identical proteins and their annotated locations for NP_034097.1

    Status: VALIDATED

    Source sequence(s)
    AK143060, CT571248
    Consensus CDS
    CCDS28069.1
    UniProtKB/Swiss-Prot
    O35486
    UniProtKB/TrEMBL
    Q3UPY3
    Related
    ENSMUSP00000043588.5, ENSMUST00000040592.6
    Conserved Domains (2) summary
    smart00247
    Location:7 → 84
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:95 → 176
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22623953..22630160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521755.2 → XP_006521818.1  gamma-crystallin S isoform X1

    Conserved Domains (2) summary
    pfam00030
    Location:37 → 118
    Crystall; Beta/Gamma crystallin
    cl02528
    Location:1 → 26
    Crystall; Beta/Gamma crystallin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35486.3 GenPept UniProtKB/Swiss-Prot:O35486

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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