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MBOAT2 membrane bound O-acyltransferase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 129642, updated on 5-Mar-2024

Summary

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Official Symbol
MBOAT2provided by HGNC
Official Full Name
membrane bound O-acyltransferase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25193
See related
Ensembl:ENSG00000143797 MIM:611949; AllianceGenome:HGNC:25193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAAT; LPCAT; LPEAT; OACT2; LPCAT4; LPLAT 2; LPLAT13
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 14.5), brain (RPKM 13.4) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
2p25.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8852690..9003684, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8876443..9027457, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8992820..9143813, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8824708-8825498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8825499-8826288 Neighboring gene inhibitor of DNA binding 2 Neighboring gene kinase D interacting substrate 220 Neighboring gene ADP ribosylation factor like GTPase 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11129 Neighboring gene Sharpr-MPRA regulatory region 5743 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8995048-8995599 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 6065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11131 Neighboring gene uncharacterized LOC124907728 Neighboring gene high mobility group box 1 pseudogene 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. Zhou X, et al. J Exp Clin Cancer Res, 2021 Apr 8. PMID 33832516, Free PMC Article
  2. CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. Yu X, et al. Cell Death Dis, 2023 Jan 12. PMID 36635270, Free PMC Article
  3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. Gijón MA, et al. J Biol Chem, 2008 Oct 31. PMID 18772128, Free PMC Article
  4. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. Tamaki H, et al. J Biol Chem, 2007 Nov 23. PMID 17890783
  5. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Swayampakula M, et al. Oncogene, 2017 Nov 9. PMID 28692057, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
    Title: CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
  2. Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer.
    Title: Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14415, FLJ90298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoserine O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylserine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysophospholipid acyltransferase 2
Names
1-acylglycerophosphate O-acyltransferase
1-acylglycerophosphate O-acyltransferase MBOAT2
1-acylglycerophosphocholine O-acyltransferase MBOAT2
1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase
1-acylglycerophosphoethanolamine O-acyltransferase
O-acyltransferase (membrane bound) domain containing 2
lyso-PA acyltransferase
lyso-PC acyltransferase
lyso-PC acyltransferase 4
lyso-PE acyltransferase
lysophosphatidic acid acyltransferase
lysophosphatidylcholine acyltransferase
lysophosphatidylcholine acyltransferase 4
lysophosphatidylethanolamine acyltransferase
lysophospholipid acyltransferase 13
membrane-bound O-acyltransferase domain-containing protein 2
NP_001308194.1
NP_001308195.1
NP_001308196.1
NP_620154.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321265.2 → NP_001308194.1  lysophospholipid acyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/TrEMBL
    B0AZU0
    Conserved Domains (1) summary
    cl00738
    Location:14 → 361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  2. NM_001321266.2 → NP_001308195.1  lysophospholipid acyltransferase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/Swiss-Prot
    Q6ZWT7
    Conserved Domains (1) summary
    cl00738
    Location:1 → 317
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  3. NM_001321267.2 → NP_001308196.1  lysophospholipid acyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/TrEMBL
    B0AZU0
    Conserved Domains (1) summary
    cl00738
    Location:14 → 361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  4. NM_138799.4 → NP_620154.2  lysophospholipid acyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_620154.2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    Consensus CDS
    CCDS1660.1
    UniProtKB/Swiss-Prot
    A9EDR2, Q6ZWT7, Q8NCE7, Q96KY4
    Related
    ENSP00000302177.3, ENST00000305997.8
    Conserved Domains (1) summary
    cl00738
    Location:13 → 450
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_135598.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  2. NR_135599.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  3. NR_135600.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  4. NR_135601.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  5. NR_135602.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  6. NR_135603.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  7. NR_135604.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  8. NR_135605.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

  9. NR_135606.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    8852690..9003684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    8876443..9027457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZWT7.2 GenPept UniProtKB/Swiss-Prot:Q6ZWT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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