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Crybb3 crystallin, beta B3 [ Mus musculus (house mouse) ]

Gene ID: 12962, updated on 5-Mar-2024

Summary

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Official Symbol
Crybb3provided by MGI
Official Full Name
crystallin, beta B3provided by MGI
Primary source
MGI:MGI:102717
See related
Ensembl:ENSMUSG00000029352 AllianceGenome:MGI:102717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in eye; gut; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in cataract 22 multiple types. Orthologous to human CRYBB3 (crystallin beta B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 2.8), stomach adult (RPKM 2.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113223705..113230102, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113075839..113082236, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22740 Neighboring gene predicted gene 43247 Neighboring gene crystallin, beta B2 Neighboring gene RIKEN cDNA 2900026A02 gene Neighboring gene RIKEN cDNA 4833439F03 gene Neighboring gene VISTA enhancer mm329 Neighboring gene predicted gene, 42161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers. Limi S, et al. Invest Ophthalmol Vis Sci, 2019 Jan 2. PMID 30646012, Free PMC Article
  2. A Common Ancestral Mutation in CRYBB3 Identified in Multiple Consanguineous Families with Congenital Cataracts. Jiao X, et al. PLoS One, 2016. PMID 27326458, Free PMC Article
  3. Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse. Graw J, et al. Invest Ophthalmol Vis Sci, 2001 Jun. PMID 11381063
  4. Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice. Lovicu FJ, et al. Development, 1998 Sep. PMID 9693140
  5. The beta crystallin genes on human chromosome 22 define a new region of homology with mouse chromosome 5. Hulsebos TJ, et al. Genomics, 1995 Jan 20. PMID 7789995

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-crystallin B3
Names
beta-B3 crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159650.1 → NP_001153122.1  beta-crystallin B3

    See identical proteins and their annotated locations for NP_001153122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    BC058522, CJ046471
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Related
    ENSMUSP00000113347.2, ENSMUST00000117143.8
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  2. NM_001359004.1 → NP_001345933.1  beta-crystallin B3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All eight variants encode the same protein.
    Source sequence(s)
    AC162528, CO428323
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Related
    ENSMUSP00000112618.2, ENSMUST00000118226.8
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  3. NM_001359005.1 → NP_001345934.1  beta-crystallin B3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    AC162528, CF739665
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Related
    ENSMUSP00000112718.2, ENSMUST00000120506.8
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  4. NM_001359006.1 → NP_001345935.1  beta-crystallin B3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    AC162528, CO428392
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  5. NM_001359007.1 → NP_001345936.1  beta-crystallin B3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    AC162528, CO428393
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  6. NM_001359008.1 → NP_001345937.1  beta-crystallin B3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    AC162528, CO046139
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  7. NM_021352.3 → NP_067327.1  beta-crystallin B3

    See identical proteins and their annotated locations for NP_067327.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.
    Source sequence(s)
    AJ272229, BC031442, CJ046471
    Consensus CDS
    CCDS19547.1
    UniProtKB/Swiss-Prot
    Q9JJU9
    Related
    ENSMUSP00000113572.2, ENSMUST00000119627.8
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113223705..113230102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254104.1 → XP_030109964.1  beta-crystallin B3 isoform X2

    UniProtKB/Swiss-Prot
    Q9JJU9
    Related
    ENSMUSP00000075440.7, ENSMUST00000076069.13
    Conserved Domains (1) summary
    pfam00030
    Location:115 → 197
    Crystall; Beta/Gamma crystallin

  2. XM_011249404.1 → XP_011247706.1  beta-crystallin B3 isoform X1

    Conserved Domains (1) summary
    pfam00030
    Location:127 → 209
    Crystall; Beta/Gamma crystallin

RNA

  1. XR_004942434.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJU9.3 GenPept UniProtKB/Swiss-Prot:Q9JJU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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